báo cáo khoa học: "The behaviour change wheel: A new method for characterising and designing behaviour change interventions" pps

... 6:42http://www.implementationscience.com/content/6/1/42Page 4 of 11RESEARCH Open AccessThe behaviour change wheel: A new method for characterising and designing behaviour change interventionsSusan Michie1*, Maartje ... possible.Additional materialAdditional file 1: Applying the Behaviour Change Wheel tocharacterise intervention strategies: Coding Materials. Behaviour Change Wheel Coding materialsAdditional file ... This requires an appropriate method for characterising interventions and linkingthem to an analysis of the targeted behaviour. There exists a plethora of frameworks of behaviour change interventions,...

Báo cáo khoa học: The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba docx

... and c-aminobutyric acid) [7]. Onekey reaction is the formation of c-aminobutyric acidby decarboxylation of glutamate, catalysed by the twoisoforms of glutamate decarboxylase, GAD65 and GAD67, ... PAGE[29] and MALDI-TOF-MS (see Supplementary material).General analytical methodsEnzymatic formation of vitamin B6derivatives and MPN(P) was detected using HPLC as described previously[2]. Peaks ... ubiquitously in mammalian tissues[15]. Decreased activity of PKH leads inter alia to a decreased availability of PLP for GAD, which cata-lyses the formation of c-aminobutyric acid, the mostpotent...

Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot

... RNAimachinery is that RNAi was initially recognized as an antiviralmechanism in plants and certain invertebrates [14]. Theevolutionary conservation of RNAi suggests a similar role for RNAi in mammals, which ... molecular modifications. Thediversity of autoantibody specificities and their associationwith particular diseases may be related to the combination ofgenetic and environmental factors that are ... suppressors of RNAi by mammalian viruses[15]. Based upon these phenomena and additional evidence for the linkage of RNAi to virus-induced cellular events,Jakymiw and colleagues [3] argue that it is...

Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... one a- helix, a helical turn and seven b-strands thatform an N-terminal hairpin and an anti-parallel b-sheet, with a characteris-tic a + b fold and a highly positive charged surface. Compared ... delPozo A & Gavilanes JG (2001) RNase U2 and alpha-sarcin: a study of relationships. Meth Enzymol 341,335–351.3 Lacadena J, A ´lvarez-Garcı´ a E, Carreras-Sangra N,Herrero-Gala´n E, Alegre-Cebollada ... SpainFax ⁄ Tel: +34 91 561 94 00E-mail: mbruix@iqfr.csic.esDatabaseStructural data has been submitted to theProtein Data Bank and BioMagResBankdatabases under the accession numbers2kaa and...

Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx

... benzo [a] pyrene-2¢-deoxyguanosineadducts affects DNA methylation by SssI and HhaI DNAmethyltransferasesOksana M. Subach1, Diana V. Maltseva1, Anant Shastry2, Alexander Kolbanovskiy2,Saulius ... dG-(-)-anti-BPDE. Biochemistry 34, 13582–13593.41 Wyszynski MW, Gabbara S, Kubareva EA, RomanovaEA, Oretskaya TS, Gromova ES, Shabarova ZA &Bhagwat AS (1993) The cysteine conserved amongDNA ... (+)-trans-B [a] P-N2-dG.GCGref5¢-GAGCCAAGCGCACTCTGACGMref5¢-TCAGAGTGMGCTTGGCTCGCG 5¢-CACCCTTGCGCTCTCTCACGC 5¢-TGAGAGAGCGCAAGGGTGCGM 5¢-TGAGAGAGMGCAAGGGTGX+CG 5¢-CACCCTTX+CGCTCTCTCAGCX+5¢-CACCCTTGCX+CTCTCTCAY+CG...

Tài liệu Báo cáo khoa học: The nuclear lamina Both a structural framework and a platform for genome organization pdf

... family, one type in lower phylalike cnidaria or nematodes and four major forms inmammals, designated A- type (lamin A and lamin C) and B-type (lamin B1 and lamin B2), in addition to anincreasing ... Gullotta F, Lattanzi G, D’Apice MR, CapanniC, Nardone AM, Columbaro M, Scarano G, MattioliE, Sabatelli P, et al. (2005) Alterations of nuclear envel-ope and chromatin organization in mandibuloacral ... compilation ª 2007 FEBS 1357MINIREVIEWThe nuclear laminaBoth a structural framework and a platform for genomeorganizationJoanna M. Bridger1, Nicole Foeger2, Ian R. Kill1 and Harald Herrmann31...

Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt

... additionalcontacts between RRM 2 and the linker region areobserved. In the case of PABP, the interdomain inter-actions are mediated through many salt bridges and van der Waals contacts between a 2 and ... ribonucleoprotein A. Nature 348,515–520.18 Liker E, Fernandez E, Izaurralde E & Conti E (2000)The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an ... protein–proteininteraction are displayed as balls and sticks.This ﬁgure was generated using the pro-gramsMOLSCRIPT and RASTER3D [57,58].C. Maris et al. The RRM domain, a plastic RNA-binding platformFEBS...

Tài liệu Báo cáo khoa học: "The Eﬀect of Corpus Size in Combining Supervised and Unsupervised Training for Disambiguation" pdf

... http://www.ims.uni-stuttgart.de/∼schuetze/colingacl06/apdx.html.Ian H. Witten, Alistair Moﬀat, and T imothy C.Bell. 1999. Managing Gigabytes: Compressing and Indexing Documents and Images. MorganKaufman.Alexander S. Yeh and Marc B. Vilain. ... techniques and wordnet hierarchies. In4th Discourse Anaphora and Anaphora Resolu-tion Colloquium.Kristina Toutanova, Christopher D. Manning, and Andrew Y. Ng. 2004. Learning random walkmodels for ... high attach-ment (above) and low attachment (below) for Example 1.Table 3 shows queries and mutual informa-tion values for Example 1. The highest valuesare 12.2 for high attachment (mechanism)...

Tài liệu Báo cáo khoa học: "The grapho-phonological system of written French: Statistical analysis and empirical validation" pdf

... Table 2. Average reaction times and errors for the grapheme frequency and grapheme entropy (uncertainty) manipulations (standard deviations are indicated into parentheses) in the immediate and ... predictability of its pronunciation. H is minimal and equals 0 when a grapheme is invariably associated to one phoneme (as for J and/ 3/)- H is maximal and equals logs n when there is total ... in a immediate naming and a delayed naming task with the same stimuli. In the immediate naming condition, participants were instructed to read aloud pseudowords as quickly and as accurately...

Báo cáo khoa học: The inﬂuence of cold shock proteins on transcription and translation studied in cell-free model systems pdf

... including transcription, RNA stabil-ity, translational and post-translational events. ThecspA-mRNA contains an 159 base 5¢-untranslatedregion bearing binding sites for regulatory proteinssuch as helicases, ... strainBL21 (Amersham) due to the lack of proteases and T7RNA polymerase. The T7 RNA polymerase was added indeﬁned amounts and its preparation was performed accord-ing to [38]. The system for ... found an increase in thetranslation of cold shock mRNAs and of cold tolerantmRNAs with the addition of CspA to a translationassay. Thus translation of non-CSPs would be sup-pressed and that...

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