báo cáo khoa học: " Requirements for ethics committee review for studies submitted to Implementation Science" doc

... Access Requirements for ethics committee review for studies submitted to Implementation ScienceMartin P Eccles1*, Charles Weijer2and Brian Mittman3AbstractThe requirement for ethics review ... of studies submitted to Implementation Science has been unclear. Therefore, inthis editorial, we set out our requirements for ethics committee review of experimental and non-experimental studies. ... as: Eccles et al.: Requirements for ethics committee review for studies submitted to Implementation Science. Implementation Science 2011 6:32.Submit your next manuscript to BioMed Centraland...

Tài liệu Báo cáo khoa học: "The Sentimental Factor: Improving Review Classiﬁcation via Human-Provided Information" docx

... techniques for infor-mation extraction increasingly useful. Traditionally,most research effort has been directed towards “ob-jective” information, such as classification accord-ing to topic; however, ... introduced in order to enforce the beliefs that:γ1≈ γ2, if a1, a2synonyms (30)γ1≈ −γ2, if a1, a2antonyms (31) For further information on regularized model fitting,see for instance, ... ones.The Sentimental Factor: Improving Review Classification viaHuman-Provided InformationPhilip Beineke∗and Trevor HastieDept. of StatisticsStanford UniversityStanford, CA 94305Shivakumar...

Báo cáo khoa học: Energetic and metabolic transient response of Saccharomyces cerevisiae to benzoic acid docx

... areknown to be important food spoilage yeasts, are able to adapt to the presence of these weak acids with alarge energy expenditure and hence are able to increasetheir tolerance to these weak ... non-dissociated form of the acid and B)isthe dissociated form (benzoate). Thus, for a certain mea-surable total benzoate concentration (CB¼ CBÀþ CHB),the fraction of the non-dissociated (protonated) ... However, to be able to performthis kind of experiment, quantitative information onthe effect of benzoic acid on cell energetics and metab-olism is required.Although some mechanisms for the...

Báo cáo khoa học: "CLASSIFICATION OF MODALITY FUNCTION AND ITS APPLICATION ANALYSIS TO JAPANESE LANGUAGE" doc

... *-kakc:u ~dasuJ (tokoro, bakari;, u~.osuru, tokoro, bakari [inchoa=ive verhl begin, commence, start: 'set about -ing'. fai to. c~me to, take to I be go ng to. be go=ng to- *-[inchoative ... classified into four semantic categories and the role of it is formalized into five modality functions. Based on these formalizations, information and constraints to be applied to the modality ... meaning. In order to obtain the logical representation of the implicative meaning, we are forced to provide different formulae expressive of the each meaning of each modal particle. For example,...

Báo cáo khoa học: "a Summarization System Integration of Opinion Mining Techniques to Summarize Blogs" doc

... Extractor for AutomaticSummarizationWe assume that, in multi-document summariza-tion, redundant pieces of information are the sin-gle most important element to produce a goodsummary. Therefore, ... ranked sentences to cre-ate a n sentences long summary. We do so becausethe clustering algorithm we use to detect sentences for all ejinEC1← ej for i from 1 to k do for j from 1 to icenter(Cj) ... sentences convey the same information.First, our system ranks all the sentences accord-ing to their similarity to the documents centroid.We have chosen to build up the documents cen-troid with...

Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx

... Spiegelman BM (2003) Peroxisomeproliferator-activated receptor-gamma coactivator 1a(PGC-1a): transcriptional coactivator and metabolicregulator. Endocr Rev 24, 78–90.31 Evans RM, Barish GD ... 1). Further studies arerequired to clarify how transcription of ANGPTL6 ⁄AGF is regulated and to identify the ANGPTL6 ⁄ AGFreceptor and its downstream effectors.ConclusionsIn this review, we ... mediated by PPARa,PPARd, PPARc and their coactivators, peroxisomeproliferator-activated receptor-c (PPARc) coactivator(PGC)-1a and PGC-1b, in response to energy overload[28–31]. We found signiﬁcant...

Tài liệu Báo cáo khoa học: A novel electron transport system for thermostable CYP175A1 from Thermus thermophilus HB27 doc

... andantibiotics [1]. Cytochrome P450s have great potential to perform numerous industrially important reactions.Indeed, cytochrome P450sca-2 from Streptomyces car-bophilus has already been used for the production ... The HPLC analysis was performedusing an HPLC system (Prominence; Shimadzu, Kyoto,Japan) equipped with an ODS-100S column (150 ·4.6 mm; Tosoh, Tokyo, Japan), and acetonitrile ⁄ metha-nol ⁄ ... [2]. However,low tolerance to various solvents and high temperaturehas generally limited the usefulness of cyto-chrome P450s for industrial applications. Thermophiliccytochrome P450s possess...

Tài liệu Báo cáo khoa học: Biosynthesis of riboﬂavin Screening for an improved GTP cyclohydrolase II mutant pdf

... Owing to the resultingcorruption of the optical readout by the stray lightcontribution, it was not possible to perform a detaileddeconvolution of the stopped-ﬂow kinetic da ta, inanalogy to ... opportunity to conduct a compre-hens ive data deconvolution, stopped- ﬂow analysisunder single-turnover conditions, as well as prest eady-state conditions, afforded useful information for comp ... tag. In order to introducemutations exclusively into the cyclohydrolase II domain ofribA and not into the 3,4-dihydroxy-2-butanone (DHB)synthase domain, error-prone PCR was performed [(usingthe...

Tài liệu Báo cáo khoa học: Helicases ) feasible antimalarial drug target for Plasmodium falciparum pptx

... responsible for the most severe form of the disease and this par-asite is developing resistance to the major antimalarial drugs. Therefore, inorder to control malaria it is necessary to identify ... motor proteins because to unwindthe duplexes they require energy, which is provided bytheir intrinsic nucleic acid-dependent ATPase activity.These enzymes act as necessary molecular tools for ... unpublished). PfDHA moves in the 3¢ to 5¢direction and prefers a fork-like substrate for itsunwinding activity [18].Helicases as drug and therapeutictargetResistance to the most efﬁcient, reasonably...

Tài liệu Báo cáo khoa học: Development of a new method for isolation and long-term culture of organ-speciﬁc blood vascular and lymphatic endothelial cells of the mouse pdf

... University of Tokyo, Japan) for help in per-forming endothelial tube formation experiments. Thiswork was supported by grants from the Japan Society for the Promotion of Science (to T. I.) and ... (Olympus, Tokyo,Japan). For immunocytochemistry, cells were ﬁxed on ice with4% PFA in NaCl ⁄ Pi for 10 min, incubated in methanol at)20 °C for 20 min, and rehydrated in NaCl ⁄ Pi. For detec-tion ... Prior to treatment with growthfactors, cells were cultured in EBM-2 basal medium with0.5% serum for 24 h. Cells were incubated with growthfactors at 33 ° C for 10 min and harvested for analysis.Tube...

Xem thêm