báo cáo khoa học: " Adiponectin receptor-1 expression is associated with good prognosis in gastric cancer" pptx

... receptor Adiponectin receptor- -1 1 1 1 expression expression expression expression is associated with is associated with is associated with is associated with good good good good prognosis in prognosis ... performed in triplicate. Immunohistochemical stainingImmunohistochemical stainingImmunohistochemical stainingImmunohistochemical staining All surgically obtained specimens were fixed in ... versions will be made available soon. Adiponectin receptor-1 expression is associated with good prognosis in gastric cancerJournal of Experimental & Clinical Cancer Research 2011, 30:107 doi:10.1186/1756-9966-30-107Tomoya...

Báo cáo khóa học: ICAM-1 expression is highly NF-jB-dependent in A549 cells No role for ERK and p38 MAPK docx

... proteins, which in vertebrates, comprises of p65(RelA), p50/p105, p52/p100, c-Rel and RelB [3]. Withinresting cells, NF-jB is retained in the cytoplasm complexedto an inhibitor protein from ... TATA binding protein (TBP) to increasetransactivation of the DNA bound NF-jB [9], or phos-phorylation of serine 276 of p65 or cAMP response elementbinding protein (CREB) binding protein (CBP), ... respectively. This is againconsistent with the published IC50value for MEK1/2inhibition (0.065 lM) suggesting that both PD098059 andU0126 are functionally active in A549 cells [26].DiscussionThe...

Báo cáo y học: "Nucleosome rotational setting is associated with transcriptional regulation in promoters of tissue-specific human genes" pot

... frequencies of dinucleotidescontaining only adenine and/or thymidine (WW dinucle-otides), with antiphased periodic frequencies of dinucle-otides containing cytidines and/or guanines (SSdinucleotides) ... cross-chain hydrogen bonds in the minorgroove, which is probably a determinant of the energeti-cally more favorable smooth versus kinked bending of theDNA [10]; and an arginine side-chain is located ... univer-sally present in eukaryotes, albeit involving differentdinucleotides. The same periodic RR/YY dinucleotidefrequency is seen in human and mouse promoters, butinterestingly the medaka fish Oryzias...

Báo cáo khoa học: VEGF gene expression is regulated post-transcriptionally in macrophages pdf

... growthfactor (VEGF) is associated with macrophage cell in l-tration in inﬂammation. Both VEGF and macrophagecells play a critical role in inﬂammatory processesincluding synovial joint in ammation ... affect increases in VEGF reporter found in activated cells. We are cur-rently extending this mapping analysis to identify addi-tional 3¢ UTR regulatory elements that are active in macrophages.DiscussionThe ... medi-ated by mRNA binding proteins that recognize cis -act-ing elements, most frequently found in the 3¢ UTRregion [26–28]. The most studied cis-acting elementsare AURE. Analysis of the human...

Báo cáo khoa học: "bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study" pptx

... and one for disease in the axilla, all with palliative intent.ImmunohistochemistrySections of paraffin-embedded metastasis specimens wereinitially stained with hematoxylin-eosin for evaluation ... location in CM prognosis [1,3,21,23,27,30,31]. In addition, the expression of bcl-2 in CM metastases wasevaluated without comparison to bcl-2 expression in nor-mal melanocytes. That comparison ... survival in the three types of CM metastasis. Thiscould be explained in three distinct ways: first, there is nocorrelation between survival and the immunohistochem-ical expression of bcl-2 in CM;...

báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot

... growthand induces apoptosis. This suggests that hindering UHRF1 to exert its role in the duplication of the methylationpatterns (DNA + histones) is responsible for inducing apoptosis. In this review, ... found in cancer.There is increasing evidence that Ubiquitin-like con-taining PHD Ring Finger 1 (UHRF1, also known asICBP90 or Np95) plays a fundamental role in these pro-cesses by being involved ... nti-UHRF1 therapeutic interest, it would be interesting toshow that diminishing but not abolishing UHRF1’ s expression by chronic treatment of natural compound is sufficient for re -expression of silenced...

Tài liệu Báo cáo khoa học: Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain doc

... preincubated with puriﬁed recombinant Cyp4x1 protein, resulting in the ablation of detection of the 55-kDa protein in brain(Fig. 5C). This shows that the antisera speciﬁcallydetect the murine ... detect Cyp4x1 in brain; quantitation of the Cyp4x1 protein in brain demonstrated  10 ngof Cyp4x1 proteinÆmg)1microsomal protein, showing that Cyp4x1 is amajor brain P450. Immunohistochemical ... Expression of Cyp4x1 proteinTo analyse the expression of Cyp4x1 protein, a full-length clone of mouse Cyp4x1 was inserted into thepRSETa expression vector (Invitrogen, Paisley, UK),and insoluble...

Báo cáo khoa học: Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis ppt

... chain;?, unknown cross-linking adducts;*, cross-linking adducts with E. coli L23;d, cross-linking adducts with E. coli Ffh;s, cross-linking adducts with B. subtilis Ffh;n, cross-linking ... protoplasts of B. subtiliscells were incubated with trypsin. In parallel, proto-plasts were incubated without trypsin or with trypsinplus Triton X-100. As shown in Fig. 3, cells producingthe authentic ... cross-linking adduct containingB. subtilis Ffh was formed upon incubation with B. sub-tilis 168 lysate in the presence of DSS (Fig. 5B, lane15). Note that the antibodies against Ffh of B. subtilisdo...

báo cáo hóa học:" Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation" pptx

... drug-resistant disease, resulting in poorclinical outcome. Likewise, studies indicate improved clinical outcome with increased presence oflymphocytes. Therefore, we sought to examine Bcl-2 expression ... purposes)Intensity of stromal Bcl-2 staining decreases with tumor progressionFigure 6Intensity of stromal Bcl-2 staining decreases with tumor progression. Intensity of stromal Bcl-2 staining was ... sta-tistical analysis of Bcl-2 staining in normal, benign, andcancerous tissue samples. Fisher's exact test was used totest for associations in extent of epithelial and stromalstaining...

báo cáo hóa học:" Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients" pdf

... survivin expression in four different ovarian carcinomas (400×, hematoxylin counterstain): a) negativesurvivin expression (clear cell carcinoma; FIGO IIIC), b) survivin expression absent in the ... P, Wall NR, Giodini A, O’Connor DS, Plescia J, Padgett KM,Tognin S, Marchisio PC, Altieri DC: Survivin exists in immunochemicallydistinct subcellular pools and is involved in spindle microtubulefunction. ... of survivin expression was found only in patients treated with taxane-plati-num agents. This relationship may be explained by afunctional link between survivin and taxanes duringmitosis [14,15].Table...

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