... 3 of 10REVIEW Open AccessThe immunoregulatory mechanisms of carcinoma for its survival and developmentCaigan Du1,2,3*, Yuzhuo Wang1,3,4AbstractThe immune system in patients detects and ... 135:234-243.doi:10.1186/1756-9966-30-12Cite this article as: Du and Wang: The immunoregulatory mechanisms of carcinoma for its survival and development. Journal of Experimental &Clinical Cancer Research ... anti- carcinoma immune cell death. Secretion of TGF-beta1 and Gal-1,expression of immune inhibitor ligands (B7-H1 -H3 and -H4), up-regulation of IDO and/ or ARG activity and/ or expansion of cellularimmunosuppression...