Báo cáo y học: "Celecoxib accelerates functional recovery after sciatic nerve crush in the rat" potx

... isstrongly upregulated around the injury site, possibly playing a role in the regulation of the inflammatory response. In this study we investigated the effect of celecoxib, a COX-2 inhibitor, on functional ... evaluated. Functional recovery was then assessed bycalculating the sciatic functional index (SFI) on days 0,1,7,14 and 21 in all groups, and registering the day of motor and walking onset. In comparison ... and pro-inflammatorycytokines have been implicated in the orchestration of the inflammatory process that lead to degeneration andregeneration after nerve injury [18]. One of thesecytokines,...

Báo cáo y học: "Long-term myocardial recovery after mitral valve replacement in noncompaction cardiomyopathy" ppsx

... MA was also instrumental in obtaining informed consent. All authorshave read and approved the final manuscript.Competing interests The authors declare that they have no competing interests.Received: ... Awareness about ILVNC hasincreased tremendously in the recent past more perti-nently in the elderly population. In the absence of largestudies and longer follow up, clinical features and long-term ... noncompaction of the left ventricle a congenitalcardiomyopathy, which is characterized by hypertrabe-culations and deep recesses in the ventricular wall ledby a defect in morphogenesis during embryogenesis...

Báo cáo y học: "Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice" pot

... understanding the molecularpathways leading to the neuroprotective action of ASA isnecessary. In conclusion our preliminary study shows that acetyl sal-icylic acid accelerates functional recovery ... twodoses (100 mg/kg/day and 50 mg/kg/day) on functional recovery following peripheral nerve injury using mouse sciatic nerve crush model. The following drugs were used for this study: Urethane(Sigma, ... followingperipheral nerve injury and it appears to be a promisingagent for treating peripheral nerve injuries. Further studiesaimed at understanding the molecular mechanismsinvolved in the...

Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study" docx

... determine more definitively the role of PPTN22 in PsA. No associations were observed with tp53 in either pop-ulation.Competing interests The authors declare that they have no competing interests.Authors' ... studies, participated in studydesign, and drafted the initial manuscript. LP assisted in gen-otyping some of the control individuals. SH aided in recruit-ment and clinical phenotyping of PsA patients. ... of the SNP site was carriedout using the MassExtend primer and involved the use of spe-cific d/ddNTP termination mixes, which were also determinedusing MassARRAY assay design software. The...

Báo cáo y học: " Identification of functional modules that correlate with phenotypic difference: the influence of network topology" potx

... signaling pathwayT cell receptor signaling pathwayB cell receptor signaling pathwayAdipocytokine signaling pathwayEpithelial cell signaling in Helicobacter pyloriinfectionPathways in cancerPancreatic ... TIF valuesmay have their influence in the network reduced bygenetic buffering effects or by the incompleteness of the topology. TIF measures the effects of pathway topologyon the biological ... some othereffect (see Discussion and conclusions). Otherwise, the gene could play an important role in perturbing the functionality of the pathway. Although we apply TIFonly to KEGG pathways in...

Báo cáo y học: "Placenta Percreta-Induced Uterine Rupture Diagnosed By Laparoscopy in the First Trimester"

... lower uterine segment; however, in cases of uterine rupture during the first trimester, the site commonly affected is the fundus, as noted in our patient [7]. The uterine ruptures in the first ... appropriate treatment. The first laparoscopic surgery during pregnancy was cholecystectomy, performed in 1991 [14]. Thereafter, laparoscopy has been widely used in pregnant women for the differential ... noted in sonography. During laparoscopy, uterine rupture with massive bleeding was detected; therefore, total abdominal hysterectomy was performed. The patient was discharged without any complications....

Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"

... study for any reason at any time. Clinical judgment of physician Subjects were withdrawn from the study (without penalty) if, in the opinion of the treating physician, it was not in the ... therapies for OA, such as exercise, heat/cold therapy, joint protection and physiotherapy/occupational therapy agrees to continue these therapies as normal avoiding changes in frequency or intensity ... within the body, may provide anti-inflammatory activity, and may improve joint flexibility (8-12). The current study indicated that both treatments reduced the WOMAC scores, which measures the...

Tài liệu Báo cáo Y học: Identiﬁcation of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf

... corresponding genes of the A201A biosyn-thetic pathway, may be related to their counterparts of the puromycin and hygromycin A biosynthetic pathways,respectively. The puromycin biosynthetic gene cluster ... type III PKSs, whichlack this domain, is scant. This domain promotes the binding of the acyl-CoA initiation unit to the ketosynthetasedomain of the PKSs for polyketide biosynthesis [35].Therefore, ... implicated in the biosynthesis of the N6,N6-dimethyl-3¢-amino-3¢-deoxyade-nosine moiety of puromycin. Because A201A contains thischemical moiety, these ataP genes are most likely implicatedin...

Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf

... resem-blance, and the functional analysis mentioned previ-ously, indicate data obtained by examining bacteriallyproduced p26 are indicative of the protein synthesized in Artemia.Localization of amino acid ... Analysis of the regulation of the molecularchaperone Hsp26 by temperature-induced dissociation: the N-terminal domain is important for oligomer assem-bly and the binding of unfolding proteins. ... neighboring monomers. The p26 modiﬁcations examined in this study are notlocated in either of these strands and they are not con-sidered further.As the basic p26 oligomer building block, dimersinteract...

Báo cáo Y học: Cold induces stress-activated protein kinase-mediated response in the ﬁssion yeast Schizosaccharomyces pombe pot

... level only after 60 min (Fig. 1).Pyp1p and Pyp2p phosphatases appear to play a key role in the dephosphorylation of the osmotic stress-activated Sty1p[20]. Interestingly, however, the Sty1p activation ... forgrowth in the cold. Surprisingly, however, the cold sensitivephenotype in atf1–or pcr1–strains is not shared by mutantsdisrupted in either sty1+or wis1+(Fig. 5), indicating that the role ... induced a strongactivation of Sty1p kinase. In this context, we tried toestimate the levels of Sty1p phosphorylation in strain TS-2(wak1–, Sty1p-Ha6H) to determine the role of Wak1p in the cold-induced...

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