... 2011; 8(2):148-155 â Ivyspring International Publisher. All rights reserved. Research Paper The Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer Kemal Atahan1, ... similarly-designed prospective studies is needed to consider of the efficacy of Bc1 and Bc2 in early diagnosis of the BC. Key words: Breast Cancer diagnosis, Serum Biomarkers, Bc1, Bc2, and ... changes in the protein content, affecting es-pecially the results of Bc1. The present study and the study by Mathelin et al. (27) demonstrated that freezing times longer than one hour results in...