Báo cáo y học: " b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryo" docx
Báo cáo y học: " 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block" pdf
... protein. The appearance of protein and peptide-reactive antibodieswas examined regularly in mothers before, during and afterdelivery. The aim of this study was twofold; first, to determinewhether ... immunoassays. JH wasinvolved in the analysis of the immunoassay results. HD per-formed and analyzed the immunoassays. VR performed and analyzed the immunoassays. DAI collected the patient sera and ... obtained by examining the reactivity of sera with 45 peptides of Ro52 and Ro60 proteins. ElevenRo peptides were recognized by IgG antibodies from at least25% of mothers included in this study. These...
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Báo cáo y học: " b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryo" docx
... Access b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryosYi-Ting Wu1, Che Yi Lin1, Ming-Yuan Tsai2, ... cell death of erythrocytes and the endocardium in zebrafish embryos by b-lapachone ismediated through an NQO1- and calcium-dependentpathway The linear arrangement of the ventricle and atrium and the ... erythrocyte-deficiency in circulation and heart- looping defect phenotypes in b-lapachone- treated embryos. These resultssuggest that the induction of apoptosis of endocardium and erythrocytes by b-lapachone...
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Tài liệu Báo cáo Y học: Convulxin induces platelet shape change through myosin light chain kinase and Rho kinase ppt
... mediated by Rho kinase and the other by the Ca2+-dependent activation of MLCkinase. These two pathways could be activated independ-ently of each other, depending on the type and concen-tration of ... rearrangements, by inhibiting actinassembly and focal adhesion in many cell types [8,9] through the decreased phosphorylation of various proteins [10,11]including MLC [12]. In a previous study of our ... Ca2+mobilization and mediated by MLC kinase [3], and the other is Ca2+-independent, subsequent to the small GTP-binding protein RhoA activation, and mediated by Rhokinase [4–6]. The Ca2+/calmodulin-dependent...
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Báo cáo Y học: Cold induces stress-activated protein kinase-mediated response in the fission yeast Schizosaccharomyces pombe pot
... level only after 60 min (Fig. 1).Pyp1p and Pyp2p phosphatases appear to play a key role in the dephosphorylation of the osmotic stress-activated Sty1p[20]. Interestingly, however, the Sty1p activation ... shock induced a quick and transient phosphorylation of Sty1p that becamedephosphorylated within 60–90 min. This is likely due to the activity of threonine-phosphatases Ptc1p and Ptc3p and tyrosine-phosphatase ... toestimate the levels of Sty1p phosphorylation in strain TS-2(wak1–, Sty1p-Ha6H) to determine the role of Wak1p in the cold-induced activation process. As shown in Fig. 2A, onlya slight increase in...
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Báo cáo y học: "Put your heart into the joint benefits of statins" pps
... of immune/inflammatory responses. The appeal of statintherapy in chronic inflammatory disease is furtherenhanced by accumulating evidence that statins mightinfluence bone metabolism (reviewed by Bauer ... metabolites in this pathway include farnesylpyrophosphate and geranylgeranyl pyrophosphate, whichare required for post-translational prenylation of a range of moieties, including signalling intermediaries, ... 4 Hall The recognition that systemic inflammatory diseases areassociated with accelerated atherosclerosis offers the prospect of reducing morbidity and mortality of affectedpatients by attention...
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Báo cáo y học: "Rheumatologists, take heart! We may be doing something right" docx
... disease orevents (heart attack and angina, coronary heart disease,coronary by- pass surgery, and stroke were included, but onlyif they occurred after RA had developed). The presence of traditional ... publication by Turesson and colleagues [2]. The real importance of this study, however, may lie in the final analysis, presented in Table 5 of their paper, whichintends to determine to what ... significantly associated with the risk forcardiovascular events. A more interesting finding was that the presence of extraarticular disease clearly increased the risk of cardiovascular events, confirming...
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Báo cáo y học: "Why are heart operations postponed" docx
... reasons, which in order of significance were:febrile situations, including infections of the respiratory, gastrointestinal and urinary system, problems with the regulation of antiplatelet and antithrombotic ... care.IntroductionEvery physician employed in the practice of heart sur-gery is aware of the fact that the psychological condition of a heart patient scheduled for cardiac surgery is a veryfragile ... er of the surgical team and checked the paper. NTwas the head of the department and made the final check of the paper. Allauthors have read and approved the final manuscriptConflicts of interest...
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Báo cáo y học: "Effects on heart pumping function when using foam and gauze for negative pressure wound therapy of sternotomy wounds" pptx
... using foam than whenusing gauze. NPWT using foam may relieve tension on the caval and lung veins in the bottom of the thoraciccavity, thereby decreasing the filling pressure in the right and ... foam may relieve tension on the caval and lung veins at the back of the thoracic cavity,thereby decreasing the filling pressure in the right and left atria. This may be haemodynamically beneficial, ... pumping function.Hitherto, the effect of NPWT on the pumping function of the heart has only been examined using foam [7-10]. The aim of the present study was therefore to compare the haemodynamic...
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Báo cáo y học: "Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators"
... all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. MK contributed tostudy concept and design, to analysis and interpretation ... sponsor. SM, AQ, and NK of Johnson and Johnson met authorship criteria by participating in the study design, analysis of results, interpretation of findings, and drafting of the paper.Independent ... analysis. The accuracy of the data analysis was inde-pendently verified by William Shannon, PhD, Associate Professor of Biostatistics in Medicine, Department of Medicine, Washington University...
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Báo cáo y học: "Emulsified Isoflurane Preconditioning Reduces Lung Injury Induced By Hepatic Ischemia/Reperfusion in Rats"
... injury such as gut and liver I/R injury22. This process is as-sociated with activation of inflammatory reaction, including the increased activity of NF-κB and the in- creased inflammatory mediators ... which infiltrate the lungs during endotoxemia, produce cytokines, such as interleu-kin-1β and TNF-α, and play a key role in the devel-opment of ALI by releasing neutrophil proteases and reactive ... Emulsified isoflurane preconditioning markedly attenuated hepatic I/R-induced lung injury in rats, which may be hopefully applied to the clinical treatment of organ injury caused by hepatic surgery,...
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