Báo cáo y học: "Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension" pptx
Báo cáo y học: "BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance" ppt
... the phenotypescan hardly be explained by the SNPs and the few immunoreg-ulatory genes that are expressed differentially in both naïve andimmunized BALB/cJ and BALB/cByJ mice. Similarly, 8 of ... as-yet-unknownfunction may affect or modify clinical phenotypes of arthritis and/or spondylitis.IntroductionRheumatoid arthritis (RA) is a chronic autoimmune diseasethat leads to inflammatory ... Jackson Laboratory (maintained since 1935),whereas the BALB/cByJ mice were inherited from the NIH andthe breeding stock was transferred to The Jackson Laboratoryin 1967, when D.W. Bailey joined...
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Báo cáo y học: "NPAS2 and PER2 are linked to risk factors of the metabolic syndrome" pps
... Biosystems7300 Real Time PCR System (Applied Biosystems, FosterCity, California, USA) according to the instructions pro-vided by the manufacturer.Custom TaqMan® SNP Genotyping Assays were ... J Biol Rhythms 2003, 18:250-60.3. Ukai H, Kobayashi TJ, Nagano M, Masumoto KH, Sujino M, Kondo T,Yagita K, Shigeyoshi Y, Ueda HR: Melanopsin-dependent photo-perturbation reveals desynchronization ... Arntl2rs35878285, Cry2 rs2863712, Ncoa3 rs2230783 and Per2S662G, so these were excluded from further analysis. Eachpolymorphic SNP was then analyzed in relation to sea-sonality and to metabolic syndrome...
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Báo cáo y học: "Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension" pptx
... antibiotics we were not able to con-firm any pulmonary vascular remodeling compared to the pulmonary vascular smooth muscle cell hyperplasiareported in TSP-1-/- mice previously by Crawford et al[15] ... been found in intrapulmonary arteries in hypoxia-induced pulmonary hypertension in mice [14].Nonetheless, the function of TSP-1 in the hypoxic pul-monary vasculature is presently unknown.Crawford ... TSP-1-/- mice. They only receivedantibiotics while they were housed prior to hypoxia. Nei-ther WT nor TSP-1-/- mice group received antibioticswhile they were exposed to hypoxia. A total of...
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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... cells? Because PARP-1 -null mice are viable and healthy [32], and inhibitors that are specific for PARP-1 are relatively non-toxic and do not directly damage DNA, PARP-1 inhibitors might be both ... with cytotoxic drugs by increasing the sensitivity of the tumors to these agents. Indeed, it has been shown that PARP-1 inhibitors not only significantly enhance the anti-tumor efficacy of the ... assay, Bryant et al. (2005) found that a BRCA2-deficient cell line V-C8, compared with the BRCA2 wild type control, exhibited extreme sensitivity to AG14361, a very potent PARP-1 inhibitor...
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Báo cáo Y học: Rodent a-chymases are elastase-like proteases pot
... specificity and inhibitor profiles, rodent a-chy-mases are elastase-like serine proteases. To our knowledge,the mast cell chymases that have been enzymaticallycharacterized to date are all chymotrypsin-like ... theallergic inflammatory reaction to exclude antigens byreleasing various inflammatory mediators, and they con-tribute to the development and modulation of otherinflammatory and physiological processes, ... and inhibitors.Further studies, such as inhibition kinetic analysis anddetailed structural analysis for MCP-5-chymostatin com-plex by X-ray crystallography, are necessary to clarify themechanism...
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Báo cáo y học: "QTc and psychopharmacs: are there any differences between monotherapy and polytherapy" ppsx
... purposes)Annals of General PsychiatryOpen AccessPrimary researchQTc and psychopharmacs: are there any differences between monotherapy and polytherapyJadranka Жulav Sumić*, Vesna Barić†, ... related to psychoactive drug treatment: a com-parison of monotherapy versus polytherapy. Ann Gen Psychiatry2005, 4:1.27. WHO: Collaborating Centre for Drug Statistics Methodol-ogy; ATC Index ... included in the study. The monotherapy groupwas consisted of thirty-two women treated with an antipsychotic or an antidepressant while thepolytherapy group was composed of twenty-nine women treated...
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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... the efficacy and safety of selective COX-2inhibitors were conducted in relatively young, healthy subjects.Our study suggests that these may not be the patients who are especially at risk for ... and regulates normal physiology, such as themaintenance of gastric mucosal integrity. Conversely, COX-2is expressed selectively after exposure to inflammatory media-tors or trauma, and has ... criteria are maintained,and those at high risk for drug side effects or complications are usually excluded. Conversely, in daily clinical practice, it isespecially at-risk patients who are likely to...
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Báo cáo y học: "Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice" pot
... the same area as demonstrated by the use ofadjacent sections.mRNA levels of pro-inflammatory cytokine genes are differentially upregulated in both adipose and livertissues of HFC-fed mice A ... Release of inflammatory mediators by human adipose tissue isenhanced in obesity and primarily by the nonfat cells: a review.Mediators Inflamm 2010, 513948.18. Juge-Aubry CE, Somm E, Chicheportiche ... resistance,diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular mechanisms underlying inflammatory eventsduring high fat diet-induced obesity are poorly defined in mouse models of obesity....
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Báo cáo y học: "Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice" pptx
... Release of inflammatory mediators by human adipose tissue isenhanced in obesity and primarily by the nonfat cells: a review.Mediators Inflamm 2010, 513948.18. Juge-Aubry CE, Somm E, Chicheportiche ... genes included in our analysis,which ranges from metabolic to cellular markers to inflammatory mediators, IL-1b is identified as one ofthe most relevant inflammatory mediator as the diseaseinduction ... the same area as demonstrated by the use ofadjacent sections.mRNA levels of pro-inflammatory cytokine genes are differentially upregulated in both adipose and livertissues of HFC-fed mice A...
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Báo cáo y học: "Early Migrating leukocytes are the source of Peroxiredoxin V during inflammation in the airway" potx
... neg-ative. Likely, PAO1 caused activation of RAWs andpossibly apoptosis of these cells. Activated RAWs releasean array of pro-inflammatory cytokines, which might ini-tiate apoptosis in epithelial ... VB, Popov BV, Kropotov AV, Tomilin NV: Bone Marrow-Derived Cells Restore Expression of Peroxiredoxin V in theAirways Following Acute Naphthalene Injury in Mice. Cyto-therapy 2005, 7:483-493.17. ... Kotaro Oizumi, Young HA, Hisam-ichi Aizawa, Junji Yodoi: Redox-reactive protein Thioredoxinprevents proinflammatory cytokine- or Bleomycin-inducedlung injury. Am J Resp and Crit Care Medicine...
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