Báo cáo y học: "Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice" pot

... isnecessary. In conclusion our preliminary study shows that acetyl sal-icylic acid accelerates functional recovery following peripheral nerve injury and it appears to be a promisingagent for treating ... functional recovery following peripheral nerve crush. Even though ASA at 50 mg/kg/daydose showed marginally higher functional recovery it wasnot significant in comparison with normal saline treat-ment. ... functional recovery following peripheral nerve injury using mouse sciatic nerve crush model.The following drugs were used for this study: Urethane(Sigma, USA), Normal Saline (Baxter, India) and ASA(Alta...

Báo cáo y học: "Simvastatin protects bladder and renal functions following spinal cord injury in rats" potx

... 9-fold increase in wet weight compared to sham animals. Following SCI, the urine to plasma osmolality ratio increased initially but decreased 1 week after SCI. Hematoxylin and eosin staining of ... locomotor recovery following spinal cord injury. J Neurochem 2007, 101:182-200.29. Pannu R, Barbosa E, Singh AK, Singh I: Attenuation of acute inflammatory response by atorvastatin after spinal ... and kidney following SCI is not clear. Our data indicate that the degree of bladder/kidney dysfunction and their recovery are dependent on the severity of injury and the associated myelin/white...

Báo cáo y học: "Smoking and nicotine exposure delay development of collagen-induced arthritis in mice" pptx

... in the recovery phase (P < 0.05). Similar results were obtained in the miceexposed to nicotine. Nicotine also showed a direct anti-inflammatory effect diminishing IL-6 production by stimulatedsplenocytes ... probably due toaCCP: anti-cyclic citrullinated peptides; CIA: collagen-induced arthritis; ELISA: enzyme-linked immunosorbent assay; FCS: fetal calf serum; H&E: hematoxylin and eosin; IL: interleukin; ... time-dependent immune-modulating effect of the sympa-thetic nervous system conferred by altering the cytokineprofile in the local lymph nodes and spleen of mice with typeII collagen-induced arthritis....

Báo cáo y học: "Gender-specific effects of HIV protease inhibitors on body mass in mice" ppt

... altera-tion in leptin binding proteins by ritonavir. Ritonavir mayregulate serum binding proteins or the soluble leptinreceptor. These binding proteins affect the stability, deliv-erance of leptin ... leptinlevels, and increased food intake in both male and femalemice. This increase in food intake did not translate toincreased abdominal fat deposition or weight gain. Inter-estingly, ritonavir increased ... metabolic syndrome [9-11]. Leptin plays a crucial rolefor regulating weight gain by controlling fat mass. Leptinlevels are positively correlated with body mass index [12].Additionally, leptin has...

Báo cáo y học: "Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan" potx

... methy-lated- and u nmethylated-specific primers, respectively[23].Flow Cytometry for DNA Ploidy703 of 1,173 tumors were available to examine the statusof DNA ploidy using flow cytometry by following ... SNP genotypingusing genome-wide Affymetrix Human SNP 6.0 arrayaccording to the manufacturer’s instructions. Genotypingwas performed by the National Genotyping Center atAcademia Sinica, Taipei, ... //ngc.sinica.edu.tw). This array contains 1.8 millions markers widely dis-tributing in human genome. After standard Affymetrixquantile normalization, the intensity data was analyzedusing Genotyping...

Báo cáo y học: "Changes of medium-latency SEP-components following peripheral nerve lesion" pps

... Campus Benjamin Franklin, Berlin, Germany, 2Department of Neurology and Clinical Neurophysiology, Fachklinik Neustadt, Neustadt, Germany and 3Department of Clinical Neurophysiology, Charité ... occur in humans, the SEP of intact neighbouring hand nerves were recorded in 29 patients with hand nerve lesions. To hypothetically explain the observed changes of SEP-components, SEP recording following ... after radial nerve lesion [4]. In contrast, the results of the present study in humans demonstrated no change of primary SEP-compo-nents of intact neighbouring hand nerves following hand nerve lesions....

Báo cáo y học: "Celecoxib accelerates functional recovery after sciatic nerve crush in the rat" potx

... MG: Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice. J Brachial Plex Peripher Nerve Inj 2007, 2:3.13. Bridge PM, Ball DJ, Mackinnon SE, Nakao Y, Brandt ... prostaglandins in the patho-genesis of neuropathic pain. Eur J Neurosci 2002, 15(6):1037-47.8. Ma W, Eisenach JC: Cyclooxygenase 2 in infiltrating inflamma-tory cells in injured nerve is universally ... Austin DR: The immunosuppres-sant FK506 increases functional recovery and nerve regener-Table 1: Motor functional recovery after sciatic nerve crush Groups (n = 5 each) SFI day 0 SFI day 1...

Báo cáo y học: "Simvastatin protects bladder and renal functions following spinal cord injury in rats." ppsx

... 9-fold increase in wet weight compared to sham animals. Following SCI, the urine to plasma osmolality ratio increased initially but decreased 1 week after SCI. Hematoxylin and eosin staining of ... urethral sphinc-ter activity parasympathetically, resulting in normal stor-age and voiding [4]. Detrusor-sphincter dyssynergia has been reported in SCI patients [5].Understanding of bladder dysfunction ... hemi-laminectomy was done at the T9-T10 level to expose the dura overlying the spinal cord [29]. Spinal cord contusion injury was induced by a controlled contusion injury (CCI) device described by...

Báo cáo y học: "Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E" pot

... prostaglandin E2 restrains airway mastcell activity in vivo and reduces airway eosinophilia and lungTh2 cytokine overproduction in a house dust mite-inducedmouse model of asthma. Int Arch Allergy ... purposes)Endogenous prostaglandin production in the airways as assayed by ELISA in BAL fluidFigure 2Endogenous prostaglandin production in the airways as assayed by ELISA in BAL fluid. Graph (a) shows ... (COX)-2activity in modulating airway reactivity and bronchialinflammation have been investigated in experimentalrodent models of asthma by various groups [10,11],including ours [12,13]. In addition,...

Báo cáo y học: "Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice" pptx

... seemed to be pro-inflammatory in ALI. In the present study, interestingly, our results indi-cated that administration of butyrate in vivo attenuatedpulmonary inflammation in LPS-induced ALI. The ... pul-monary injury in ALI induced by LPS in mice [28,29]. In the present study, the concentrations of TNF-a andIL-1b in BALF and the expression of NF-Bp6 5in nucleus increased significantly after ... IL-1b,playakey role in neutrophil recruitment to the lung. There-fore, the reduced neutrophils infiltration in lung bybutyrate administration was partially due to its inhibi-tory effect on cytokines...

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