... receptors involved in Clozapine therapy included D4, D2, serotonin type 2, norepinephrine, acetylcholine, and histamine [20-22]. Functional brain imaging methods have been applied for studying schizophrenia. ... hallucination. By contrast, drugs such as amphetamine reinforce signal transmissions by dopamine and induce schizophrenic symptoms such as delusion and hallucination. A large body of theory and ... hypofrontality was mostly cleared. However, in some areas like temporal and caudate, hyperfrontality was induced. Negative symptoms showed linkage to hypofrontality in both groups before and after...