Báo cáo y học: "Circadian phase response curves to light in older and young women and me" pot
Báo cáo y học: "Circadian phase response curves to light in older and young women and me" pot
... phase response curves to light in older and young women and menDaniel F Kripke*1, Jeffrey A Elliott1, Shawn D Youngstedt2 and Katharine M Rex1Address: 1Department of Psychiatry and ... preliminary health screening and home actigraphic recording baselines, 50 young adults (ages 18–31 years) and 56 older adults (ages 59–75 years) remained in light- controlledlaboratory surroundings ... sleepwake cycle is a protocol used successfully by several labo-ratories to reduce sleep and light masking of circadianrhythms [22-26]. Although maintained in standardizedlighting and ultra-short...
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Báo cáo y học: "Circadian phase-shifting effects of a laboratory environment: a clinical trial with bright and dim light" ppsx
... purposes)JAE assisted in designing the study and drafting the man-uscript and performed the aMT6s assays.KMR assisted in designing the study, in laboratory datacollection, and in drafting the manuscript.AcknowledgementsThis ... to light in older adults. Preliminaryevidence suggests that aging subjects may display smaller phase shifts to light stimuli [11,12]. Thus, older adultsmight require increased exposure to light ... the final CES-D score.AssaysUrinary concentrations of 6-sulphatoxymelatonin(aMT6s), the primary metabolite of melatonin, wereassayed with a highly specific RIA assay developed byAldous and...
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Báo cáo y học: "Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response" potx
... B-celldepletion - is probably due to survival of memory B cells, whichexpand in secondary lymphoid tissues and produce autoanti-bodies. In line with this hypothesis, Leandro and colleaguesreported ... count test results,according to the following equation:ResultsClinical characteristics of the patients and response to rituximab therapyThe clinical and laboratory characteristics of the ... V, Perry JW, Arkfeld DG, Ehresmann GR,Migone TS, Hilbert DM, Stohl W: Local production of B lym-phocyte stimulator protein and APRIL in arthritic joints ofpatients with inflammatory arthritis....
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Báo cáo y học: " Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trials" ppsx
... "successfultreatment" was defined using CGI score-based thresholds[3]. In this analysis, we assess cumulative time spent in response and time maintaining response, defining response by changes in CGI, a global ... frequently preceded by symptom wors-ening [5]. In a large meta-analysis in which efficacy was primarilymeasured as a change from baseline in Positive and Neg-ative Syndrome Scale [6] (PANSS) Total ... each study individuallyare to compare by treatment: time maintaining response, proportion of patients losing response, number needed to treat (NNT) with olanzapine rather than comparator to prevent...
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Báo cáo y học: "Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance training"
... resistance training in predicting main (hSGLT3 and GLUT4 gene and protein expression levels) and secondary (muscle glycogen stores and muscle strength) study outcomes, analysis of covariance ... diabetes have type 2 diabetes. It results from insulin resistance combined with relative insulin deficiency [1]. Both insulin resistance and deficiency leads to hyperglycemia due to altered glucose ... glucose intolerant and diabetic subjects have demonstrated that increased physical activity enhances insulin sensitivity and insulin-dependent glucose uptake in skeletal muscle by regulating the...
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Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx
... immunologically relevant genes, including certain major his-tocompatibility complex (MHC) loci, Fcγ receptor, and cytokines [1]. 1,25-dihydroxyvitamin D3 is thought to exertmany of its action through interaction ... betweenVDR polymorphism and many non-skeletal diseases [20].Although SLE has features consistent with Th2-type cytokinepredominance, both Th1 and Th2 cytokine may be involved in the pathogenesis ... pancreas,bone, skin, gonads, and activated T and B lymphocytes, havethe nuclear receptor for 1,25-dihydroxyvitamin D3 (VDR).Thus, it is not surprising that 1,25-dihydroxyvitamin D3 has amultitude...
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Báo cáo y học: "Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid disease" docx
... analysis was 43.5 ± 15.3 years and 35 ± 9.9 years for Tunisian and Turkish controls, respectively.There was no clinical evidence or family history of autoimmunedisease and inflammatory joint ... Turkey approved the study protocol.MethodsAutoantibodies analysis In AITDs patients, thyroid autoantibodies (anti-thyroglobulin and anti-thyroid peroxydase) were measured by ELISA and indirect ... 0.05).Extremely skewed XCI have been reported in 1 to 2% of 20 to 40 year old women, and in 2 to 4% of 55 to 72 year old women [19]. The data for RA and AITDs patients is strikingly bimodal,we...
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Báo cáo y học: "Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndrom" pps
... presentingwith hypoglycemia ± finger-clubbing. Hypoglycemia and finger-clubbing almost always completely resolve follow-ing surgical excision, usually with no complications, butthe symptoms may ... episodes of symptoms ofsevere hypoglycemia including syncope. He had a 20pack-year history of smoking. He was found on examina-tion to have marked finger-clubbing and decreased breathsounds in the ... by Doege and Potter independ-ently in 1930 hence the eponym Doege-Potter syndrome[DPS] [1,2]. Hyperthrophic osteoarthropathy clinicallyobserved as finger-clubbing is also associated withintrathoracic...
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Báo cáo y học: "Radiographic correlates of hallux valgus severity in older people" pot
... contributed to interpretation of the data, and read and approved the final version of the manuscript.Competing interestsHBM, KBL and SEM are Editor -in- Chief, Deputy Editor -in- Chief and AssociateEditor, ... valgus; rather, they are likely to develop in response to increasing hallux valgus deformity. However,as the inclusion criteria for this study involved partici-pants over 65 years of age, it ... arch height and hallux valgus severity identified in our study, we suggest furthe r research is needed to investigate this relationship more definitively.The findings of this study need to be considered...
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Báo cáo y học: "Three variations of the laryngeal nerve in the same patient: a case report" potx
... mainly depends on thesurgical anatomy of the ILN. The nerve has many varia-tions on its cervical course and full knowledge of RLNanatomy, including all variations, is obl igatory for athyroid ... is mainly sensi-tive [4,9]. In some cases, the posterior branch also hasmotor fibers, and may affect laryngeal function. It mayinnervate posterior cr icoarytenoid (abductor function) and interarytenoid ... possibility of a no n-recurrent nerve must betaken into acco unt. Complete exposure of the RLN ismandatory to avoid nerve injury; especially near theBerryligamentwherethenerveismoresuperficialandvulnerable...
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