A–Z of Haematology - part 6 pps

... transformation of myelopro-liferative disorders, forming AML 1- EAP, AML1-EVI1 and AML-MDS1• part of ETV6 to form a fusion gene,ETV6-AML1 (TEL-AML1), detected in about 30% of cases of acute lymph-oblastic ... locus) -3 -N-acetyl Dgalactosylaminyltransferase(encoded byA1 allele* at theABO locus)AB(b)Locus Allele TransferaseFUT1ABOHhABO -2 -L-fucosyltransferasenil -3 -N-acetyl-D-galactosaminyltransferasenil -3 -D ... t(12;21)(p13;q22)• part of MTG 16 to form a fusion gene, AML1-MTG 16, mainly in sec-ondary acute myeloid leukaemia/myelodysplastic syndrome associatedwith t( 16; 21)(q24;q22)• part of USP25 to form an AML 1- USP25...

... witht(3;4)(q27;p13)•a SRP20-BCL6 fusion gene in non-Hodgkin’s lymphoma with t(3 ;6) (q27;p21)• an H4-BCL6 fusion gene in non-Hodgkin’s lymphoma with t(3 ;6) (q27;p21)• an IKAROS-BCL6 fusion gene in non-Hodgkin’s ... chromosome num-ber that is not 46 nor a multiple nor half of 46 aneuploidy presence of a clone of cellswith a number of chromosomes which isnot 46 nor a multiple nor half of 46 aneurysm a localized ... cells of themajority of cases of B-lineage acute lymphoblastic leukaemia, more weakly onthe blast cells of some cases of T-lineageacute lymphoblastic leukaemia, on thecells of many cases of...

... CD60b and CD60cCD60a a glycolipid, GD3CD60b a glycolipid, 9-O-acetyl-GD3CD60c a glycoclipid, 7-O-acetyl-GD3CD61 a surface membrane glycoprotein,the β3 integrin chain, GpIIIa; part of the GpIIb/IIIa ... conditionfrom non-Hodgkin’s lymphoma; ex-pressed on the blast cells of some cases of acute lymphoblastic leukaemiaCD80 ligand of CD28 and CD152; co-regulator, with CD 86, of T-cell activa-tion; engagement ... mono-clonal antibodies to CD66a, b, c and ehave been used for conditioning prior tostem cell transplantationCD66b (previously CD67), biliary glyco-protein, member of the carcinoembry-onic...

... central part of a bonecomposed of an anastomosing network of trabecular or cancellous bone (ii) thecentral part of the kidney (iii) the central part of a lymph node (iv) the central part of the ... molecules (HLA-A, HLA-B and HLA-C) are concerned with recog-nition of antigens expressed on alteredbody cells and class II molecules (HLA-DP, HLA-DQ and HLA-DR) with therecognition of foreign ... leukaemiainterferon-ααone of two classes of cytokines synthesized by virus-infectedcells that conveys, to other cells, resist-ance against viral infectioninterferon-ββone of two classes of cyto-kines...

... 210Table 16 Some of the genetic causes of severe combined immunodeficiency.DefectDeficiency of Janus-associated kinase 3Deficiency of common γ chain of receptors for IL-2, IL-4, IL-7, IL-9 and ... rearrange-ment of the regions of an immunoglo-bulin or T-cell receptor gene (see Fig. 46, p. 135)red cell an erythrocyte, a non-nucleatedcell of the peripheral blood the main func-tion of which ... neutrophil a mature neu-trophil with a nucleus divided into lobesor segmentsselectin one of a family of three celladhesion molecules, E-, L- and P-selectin(CD62E, CD62L and CD62P)SEM scanning...

... inblast cells of 88% of cases of acute lym-phoblastic leukaemia and 97% of cases of acute myeloid leukaemia.Wolman’s disease an inherited meta-bolic disorder, a juvenile form of choles-terol ester ... patients of any blood group, i.e. an O Rh D-negativedonor (without a high titre of anti-A oranti-B antibodies)universal precautions an approach to prevention of transmission of blood-borne ... electronmicroscopeU225HAE-U 01/13/2005 05:16PM Page 225whole chromosome painting a tech-nique for identifying individual chromo-somes by the use of a combination of probes that bind with a high level of spec-ificity...

... in 861 , Arch-bishop Hincmar of Reims took over the writing of the Annals of St-Bertin, until his own death in 882.Like the Royal Frankish Annals and the Annals of Fulda, the An-nals of St-Bertin ... of Bremen’s History of the Arch-bishops of Hamburg-Bremen.Ansgar, a monk from Corvey Abbey, Westphalia (present-day Ger-many), was first sent to Scandinavia by Louis the Pious in 8 26, fol-lowing ... monastery of St-Bertin in present-day France, they were not com-posed there: the earliest and only complete manuscript of the Annalswas preserved in this monastery. The Annals of St-Bertin begin...