A–Z of Haematology - part 4 ppt

... ex-pression in about a third of cases of acuteleukaemia and chronic granulocytic leuk-aemia, particularly in blast crisisDDAVP 1-deamino-6-D-arginine vaso-pressin, desmopressin acetateD-dimer ... KIP2INK4 family p16INK4ACDKN2A at 9p21 p16(INK4A), CDK4 inhibitor, CDKN2p15INK4BCDKN2B at 9p21 p15(INK4B), CDK4B inhibitorp18INK4CCDKN2C at 1p32 p18(INK4C)p19INK4DCDKN2D at 19p13 P19(INK4D)HAE-C ... deletion of part of a chromo-some, either part of the long arm or part of the short arm (del) (ii) deletion of aDNA sequence with the regions on eitherside being rejoineddementia loss of higher...

A–Z of Haematology - part 1 pptx

... TransferaseFUT1ABOHhABO -2 -L-fucosyltransferasenil -3 -N-acetyl-D-galactosaminyltransferasenil -3 -D galactosyltransferaseFigure 3 ABO antigens.The formation of ABO antigens: (a) formation of H antigen ... transformation of myelopro-liferative disorders, forming AML 1- EAP, AML1-EVI1 and AML-MDS1• part of ETV6 to form a fusion gene,ETV6-AML1 (TEL-AML1), detected in about 30% of cases of acute lymph-oblastic ... permission of the publisher.First published 2003 by Blackwell Publishing LtdLibrary of Congress Cataloging-in-Publication DataBain, Barbara J.A-Z of haematology/ Barbara Bain.p. ; cm.ISBN 1 -4 051 0-3 2 2-1 1....

A–Z of Haematology - part 7 ppt

... central part of a bonecomposed of an anastomosing network of trabecular or cancellous bone (ii) thecentral part of the kidney (iii) the central part of a lymph node (iv) the central part of the ... at11q23• MLL-FBP17 in ins(11;9)(q23;q 34) inv(11)(q13q23)• MLL-CALM in inv(q 14, 2q23.1)• MLL-GPNH in t(11; 14) (q23;q 24) • MLL-AF17 in t(11;17)(q23;q21)• MLL-RARA in t(11;17)(q23;q12)• MLL-EEN in ... molecules (HLA-A, HLA-B and HLA-C) are concerned with recog-nition of antigens expressed on alteredbody cells and class II molecules (HLA-DP, HLA-DQ and HLA-DR) with therecognition of foreign...

A–Z of Haematology - part 2 docx

... chromosome num-ber that is not 46 nor a multiple nor half of 46 aneuploidy presence of a clone of cellswith a number of chromosomes which isnot 46 nor a multiple nor half of 46 aneurysm a ... of severe asthma and anti-CD4monoclonal antibodies have also beenused in psoriasisCD4 is expressed on blast cells of many cases of T-lineage acute lympho-blastic leukaemia and on cells of ... cells of themajority of cases of B-lineage acute lymphoblastic leukaemia, more weakly onthe blast cells of some cases of T-lineageacute lymphoblastic leukaemia, on thecells of many cases of...

A–Z of Haematology - part 3 pdf

... chain; the β chain of VLAs (verylate activation antigens) including VLA-1(CD49a/CD29), VLA-2 (CD49b/CD29),VLA-3 (CD49c/CD29) and VLA -4 (CD49d/CD29); VLA-2 is platelet glyco-protein IaIIa, a ... expressed on hairy cells 42 CD 24 HAE-C 01/13/2005 05:10PM Page 42 of cases of lymphoplasmacytoid lym-phoma and a quarter of cases of hairy cell leukaemia; the lack of expression inchronic ... 10%) of cases of multiple myeloma and non-Hodgkin’slymphoma, particularly MALT-type58 CDw93HAE-C 01/13/2005 05:10PM Page 58being associated with CD42a and CD42d;mutations of the CD42b gene...

A–Z of Haematology - part 5 potx

... 113GlucoseATPADPHexokinaseGlucose-6-phosphateFructose-6-phosphateFructose-1,6-diphosphateGlyceraldehyde-3-phosphate1,3-biphosphoglycerate3-phosphoglycerate2-phosphoglyceratePhosphoenolpyruvatePyruvateLactateDihydroxyacetonephosphateHaemoglobinMethaemoglobinATPADPGlucosephosphate ... is mutated in about10% of cases of multiple myeloma and in about 10% of cases of non-Hodgkin’slymphoma, particularly MALT-typenon-Hodgkin’s lymphoma and extra-nodal B-lineage diffuse large ... Seat FUT2 locus) -3 / 4- L-fucosyltransferase(encoded by Leat FUT3 locus) -3 / 4- L-fucosyltransferase -3 -N-acetyl-D-galactosaminyltransferase(encoded by A atABO locus)H type 1LeaFinal...

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A–Z of Haematology - part 6 pps

... hemizygosityHAE-H 01/13/2005 05:12PM Page 1 24 SCFHSCSCFFTL3LIL7CLPTBNKLDCIL2IL7IL6SCFIL2SCFFLT3LIL3IL4IL6GM-CSFSCFIL3IL6GM-CSFCMPIL3GM-CSFG-CSFM-CSFIL3, GM-CSF,G-CSFIL3GM-CSFM-CSFGFU-GMGFU-GGFU-MMDCIL3IL5SCFIL3IL4SCFIL3IL4SCFIL3,SCF,GM-CSFIL11,EPOIL3,GM-CSFIL11,EPOSCF,IL1, ... GM-CSF,G-CSFIL3GM-CSFM-CSFGFU-GMGFU-GGFU-MMDCIL3IL5SCFIL3IL4SCFIL3IL4SCFIL3,SCF,GM-CSFIL11,EPOIL3,GM-CSFIL11,EPOSCF,IL1, IL3,IL6, GM-CSF,G-CSF, TPOSCF,IL3, IL6,IL9, IL11,GM-CSF, ... TPOCFU-EoCFU-BasoCFU-MastBFU-EBFU-MegaCFU-MegaCFU-EPSCBi-, tri- andmultipotentprogenitorsLineagecommittedprogenitorsFigure 41 Haemopoiesis.A diagrammatic representation of haemopoiesis...

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A–Z of Haematology - part 9 potx

... 210Table 16 Some of the genetic causes of severe combined immunodeficiency.DefectDeficiency of Janus-associated kinase 3Deficiency of common γ chain of receptors for IL-2, IL -4 , IL-7, IL-9 and IL ... rearrange-ment of the regions of an immunoglo-bulin or T-cell receptor gene (see Fig. 46 ,p. 135)red cell an erythrocyte, a non-nucleatedcell of the peripheral blood the main func-tion of which ... fluoresce(b)2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 Figure 63 Real-time Polymerase Chain Reaction (RQ-PCR).There are a number of techniques available which make a PCR semi-quantitative....

A–Z of Haematology - part 10 doc

... activation of macrophagesand for T-cell mediated cytotoxicitytype 2 (Th2) helper T cell a CD4+helper T cell that secretes interleukin -4 , interleukin-5, interleukin-6, interleukin-9,interleukin-10 ... inblast cells of 88% of cases of acute lym-phoblastic leukaemia and 97% of cases of acute myeloid leukaemia.Wolman’s disease an inherited meta-bolic disorder, a juvenile form of choles-terol ester ... Four, also known as RAS Homo-logue gene family member H(ARHH),gene map locus 4p13, encoding a haemo-poietic-cell-speciﬁc small GTPase of theRho subfamily of RAS-like molecules; isinvolved...

A Principles of Hyperplasticity Part 4 ppt

... Equation (4. 53) ijijuwV wH (4. 55) uswT w (4. 56) Equations (4. 54)  (4. 56) are sufficient to establish the constitutive behaviour. For convenience of the derivation of incremental ... *ggij ij ijyyywww wV wF wV (4. 40) 4. 14 Summary 75 The second potential is the specific mechanical dissipation, a function of state and the rate of change of internal variable ,, ,ij ... definition of ed. Thus we obtain eijij ijdcwwF /wD wD (4. 47) An example of this type of constraint is given in Section 10.3.1. 4. 7 Incremental Response 65 The first two rows of the...

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A–Z of Haematology - part 9 potx

A–Z of Haematology - part 4 ppt