Báo cáo y học: "Functional characterization of Trip10 in cancer cell growth and survival" ppsx
Báo cáo y học: "Functional characterization of Trip10 in cancer cell growth and survival" ppsx
... Overex-pression of Trip10 in IMR-32 cells caused Trip10 and huntingtin to colocalize and form perinuclear foci. In contrast, while overexpression of Trip10 in CP70 cellsalso increased huntingtin level ... with Trip10- overexpressing IMR-32 cells (Figure 4A). On theother hand, huntingtin increases cell death by promot-ing apoptosis. Thus, high levels of huntingtin in Trip10- overexpressing CP70 cells may lead to cell ... is hypermethylated in brain tumor and breast cancer, but hypomethylated in liver cancer. Overexpressed Trip10 was associated with endogenous Cdc42 and huntingtin in IMR-32 brain tumor cellsand...
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Báo cáo y học: "Measuring effectiveness of drugs in observational databanks: promises and perils" pdf
... bias in assignment of treatment by aphysician. ‘Confounding by indication’ means that certaintreatments are preferentially given to sicker patients and certain treatments preferentially to ... in improvingthe use of databanks. Many of the problems with observa-tional studies can be minimized with careful planning in advance of the study. Ideally the subjects in longitudinaldatabanks ... JL:Auranofin therapy and quality of life in patients with rheuma-toid arthritis. Results of a multicenter trial. Am J Med 1986, 81:565-578.3. Pincus T: Limitations of randomized clinical trials...
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Báo cáo y học: "Current role of surgery in small cell lung carcinoma" pot
... 1Department of Cardiothoracic Surgery, School of Medicine, University of Patras, Greece and 2Department of Anaesthesiology and Critical Care Medicine, School of Medicine, University of Patras, ... presence of nodal involvement. In stage I surgerymust always be followed by adjuvant chemotherapy, while in stage II and III surgery must be plannedonly in the context of clinical trials and after ... survival wasshown in the two groups of the study: 4 year survival of 3% in the surgery arm and 7% in the radiotherapy arm. A5 year survival of 5% was noted only in the radiotherapyarm. This report...
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Tài liệu Báo cáo khoa học: Functional characterization of an orphan cupin protein from Burkholderia xenovorans reveals a mononuclear nonheme Fe2+-dependent oxygenase that cleaves b-diketones ppt
... NidetzkyInstitute of Biotechnology and Biochemical Engineering, Graz University of Technology, AustriaIntroduction In terms of their physiological functions, which includeenzymatic catalysis, ... Gillingham, UK). Production of superoxide byxanthine oxidase was followed indirectly by measuring theincrease in absorbance at 550 nm resulting from cyto-chrome c being reduced by superoxide in ... Fe2+-pirin [25].Metal coordination by a tetrad of three histidines and one glutamate was likewise seen in other members of the cupin protein superfamily, including oxalateoxidase (germin) [6]. Interestingly,...
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Tài liệu Báo cáo Y học: Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum pdf
... threedomains and are present in the inhibitory receptors of Fig. 6. Inhibition of in vitro cytotoxicity of myotoxins I or II by DM64.Cytotoxicity was analyzed in vitro using C2C12 skeletal muscle cells.Toxins ... residues phenylalanine and tyrosine typical of the Ig-fold are bold in each domain.Fig. 5. Inhibition of in vivo myotoxicity of myotoxins I or II by DM64.Groups of four mice were injected intramuscularly ... Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2from Bothropsasper venom. Identification of a heparin-binding and cytolytictoxin region by the use of synthetic...
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Tài liệu Báo cáo Y học: Functional analysis of a small heat shock/a-crystallin protein from Artemia franciscana docx
... standard curvewas prepared by electrophoresing different amounts of cell free extract from Artemia cysts containing p26 in 12.5%SDS polyacrylamide gels, blotting t o nitrocellulose and probing ... (1992) Expression and aggre-gation of recombinant aA-crystallin and its two domains. Bi ochim.Biophys. Acta 1130, 267–276.8. Augusteyn, R.C. (1998) a-Crystallin polymers and polymerization:the ... termed the a-crystallindomain, distinguishes a ll small heat shock/a-crystallinproteins, and a two or three domain structure is proposedfor these proteins [7,8]. The a-crystallin domain, locatedtoward...
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Tài liệu Báo cáo Y học: EPR characterization of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates potx
... Egmond1 and Martina Huber31Unilever Research Vlaardingen, the Netherlands;2University of Groningen, Laboratory of Biophysical Chemistry,Groningen, the Netherlands;3Department of Molecular Physics, ... Functionalanalysis of the copper dependent quercetin 2,3-dioxygenase.1. Ligand-induced coordination changes probed by X-ray crys-tallography: inhibition, ordering effects and mechanistic insights.Biochemistry, ... other,indicating a substantial perturbation of the axial symmetry of the tensor, whereas axial symmetry, i.e. gxx% gyy<< gzzis typically found for type 2 sites. The grouping of theg-values...
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Báo cáo khoa học: Functional characterization of front-end desaturases from trypanosomatids depicts the first polyunsaturated fatty acid biosynthetic pathway from a parasitic protozoan ppt
... FAs have a key role in maintaining thecorrect membrane fluidity in poikilothermic organisms,which is necessary for the mobility and function of embedded proteins and in giving shape to membranecurvatures, ... homology. Moreover, they indicate that a com-plete pathway for very-long-chain polyunsaturated fatty acid biosynthesisis functional in L. major using D6, D5 and D4 desaturases. In trypano-somes, ... easy to recognize. Theycontain a fused cytochrome b5 as an N-terminaldomain and three histidine boxes in the desaturase(C-terminal) domain. The third histidine box has theQX2HH instead of...
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Báo cáo Y học: Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes pot
... Groningen, theNetherlands) in order to obtain a recombinant proteincontaining the C-myc epitope followed by six histidines atthe C-terminus. A plasmid containing the wild type version of CCR5 ... concentration; insertion of detergent into the membrane should result in a gradualdecrease of RET [41,42], and lysis of the liposomes in abruptabolition of RET. A decrease in RET results in an increase in ... theC-terminus of CCR5 would interfere with the protein’sability to function as a chemokine receptor or HIVcoreceptor, we first determined the binding of MIP-1a tothe CCR5-myc-his expressing cells. Cells...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... (1997) The crystal structures of Sinapis alba myro-sinase and a covalent glycosyl±enzyme intermediate provideinsights into the substrate recogn ition and active-site machinery of an S-glycosidase. ... 200220 lL of the enzyme/inhibitor mixture to 180 lLofsubstrate (4NPGlc), incubating for 30 min at 37 °C, and measuring the rel ease of 4NP.Protein assays and protein sequencingTotal protein in crude ... (naringin)Hesperetin-7-GlcRha (hesperidin)Dihydrochalcones Phloretin-7-Glc (phlorizin)Secoiridoids OleuropeinAnthocyanidins Cyanidin-3-Glc (kuromanin)Cyanidin-3,5-diGlcFig. 4. Structure s of...
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