Báo cáo y học: "Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity" potx

... AccessInduction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1- induced in vitro metastatic and transformation activityChung-Yin Wu1†, Chih-Ta Lin2,3†, Min-Zu Wu2, Kou-Juey ... et al.: Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1- induced in vitro metastatic and transformation activity. Journal of Biomedical Science 2011 18:1.Submit your next ... targets of NBS1 overexpression. Knockdown of HSPA4 or HSPA14 decreased in vitro migration and invasion activity To test the role of HSPA4 and HSPA14 in in vitro migra-tion and invasion activity,...

Báo cáo y học: "Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes" pps

... chronic inflammatory disease of unknown etiology thattargets the synovium. Intimal lining macrophages and fibro-blast-like synoviocytes produce pro-inflammatory cytokinesthat contribute to synovial ... RA.IntroductionRheumatoid arthritis (RA) is a chronic inflammatory diseasecharacterized by synovial lining hyperplasia and sublining infil-tration of inflammatory cells [1]. Fibroblast-like synoviocytes(FLSs) ... in rheumatoid arthritis synoviocytesDeepa R Hammaker1, David L Boyle1, Tomoyuki Inoue2 and Gary S Firestein11Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine,...

Tài liệu Báo cáo Y học: Induction of (2¢)5¢)oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide docx

... activated by certain classes of RNA, mainly double-stranded RNA [14]. In vertebrates the (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the(2–5)A synthetase ... thin-layer chromatog-raphy, immunologically and by high-performance liquidchromatography. The biological activity of (2–5)A oligo-mers was veriﬁed by inhibition of the protein synthesis in rabbit ... c).DISCUSSIONInhibition of cell growth, apoptosis and inhibition of protein synthesis are ways of protection of metazoanorganisms against death caused by microbes. The b acterialendotoxin LPS causes...

Báo cáo y học: "Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis" doc

... potent inhibitor for the synthesis of proin-flammatory cytokines in monocytes/macrophages and T cells[11], is substantially expressed by lining macrophages and infiltrating T cells in the inflamed ... analysed by flow cytometric analysis, and the cytokine-mediated M-CSFR induction was expressed by the ratio of the mean fluorescence intensity (MFI) of M-CSFR expression with cytokines to the ... NJ: Cytokines in chronic inflammatoryarthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimu-lating factor (CSF-1) and a...

Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf

... pro-file was similar to that induced by a combination of IL-1/TNF,which might indicate the involvement of an inflammatorycytokine-mediated pathway in the observed induction of MMPs by S. aureus.S. ... expression of a 92-kD gelatinase (type V collagenase) by rheumatoid syno-vial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Clin Invest 1991, 88:1656-1662.34. ... importance of the proinflammatory cytokines TNF-α and lymphotoxin (LT)-α in an experimental model of S. aureus sep-sis and arthritis was examined by Hultgren and colleagues[36]. Using TNF-α/LT-α-double-deficient...

Báo cáo y học: " Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos" pptx

... process during embryonicdevelopment and is often accompanied by apoptosis in certain time windows. Vertebrate embryos, includingFigure 3 Quantification of cell cycle-related gene expressions in tbx5 ... in vitro [30]. Our results revealed tbx5 insufficiency ultimatelyresulted in activation of apoptosis and inhibition of cellgrowth in whole individual of zebrafish embryo, thoughknockdown of ... and diminishedcell viability [22-24]. In addition, resynthesis of ATPdecreased in the mitochondria of apoptotic cells, and arelatively low ratio of ATP to ADP can be used to monitor apoptosis....

Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

... ubiquitylated by E-cadherin-binding E3 ubiqiutin ligase upon Srcactivation, ultimately leading to endocytosis of theE-cadherin complex. Accordingly, in the course of Decma-induced disruption of ... anonredundant and isoform-speciﬁc role for Shc in theErk signaling induced by the E-cadherin blockage.Decma-induced Shc tyrosine phosphorylation and itsbinding to Grb2 were completely repressed by pretreat-ment ... previously in the control of cell adhesion. Inhibition of Src catalytic activity by overexpression of dominant inhibitory c-Src or by spe-ciﬁc inhibitors stabilizes E-cadherin-dependent cell–celladhesion...

Báo cáo khoa học: Induction of raft-like domains by a myristoylated NAP-22 peptide and its Tyr mutant potx

... [23]. In addition, the protein has no hydropho-bic segment and its free energy of partitioning intomembranes can be accounted for by the insertion of itsmyristoyl group [11]. Myristoylated ... using a myristoylatedN-terminal peptide of NAP-22, Myristoyl-GGKLSKKKKGYNVNDEKAK-amide. It is known that in vivo, in addition to the intact NAP-22 protein, a signiﬁcantamount of myristoylated ... and PtnIns(4,5)P2 into domains, we suggestthat the protein recruits more PtnIns(4,5)P2 into raft-like domains. This will result in an increase in theinteractions between the cytoskeleton and...

Báo cáo Y học: Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites doc

... supported by the existence (at least in Ets-1 and Ets-2) of an auto-inhibitory domain w hich, in t he absence of a ccessory factors,prevents Ets-1 binding to DNA [ 10,17]. W hen this d omain i sremoved, ... amino acids 244±331) of the auto-inhibitory domain w ere made ( Fig. 3A). Thesetruncated proteins were shown to r eadily bind to ETSresponse elements [10]. To verify that our truncatedproteins ... sremoved, Ets-1 binds DNA with higher af®nity even in theabsence of a ccessory factors. The auto-inhibitory domain islocated within exon VII and a n alternative ly spliced form of Ets-1 t hat...

Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt

... permeability wasmonitored by assessing the quenching of calcein dye trapped in egg phosphatidylcholine liposomes by Co2+, as described by Longland et al. [25].Tryptophan ﬂuorescence to follow ... FEBS 2002Inhibition of SERCA Ca2+pumps by 2-aminoethoxydiphenyl borate(2-APB)2-APB reduces both Ca2+binding and phosphoryl transfer from ATP, by interferingwith the pathway leading to the ... lead to protonation of an uncharged 2-APB molecule bound to the enzyme, thereby increasing the effectiveness of 2-APB asan inhibitor of ATPase activity.Toyoshima et al. have identiﬁed the amino...

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