Involvement of p63 in the herpes simplex virus-1-induced demise of corneal cells Research ppt
Involvement of p63 in the herpes simplex virus-1-induced demise of corneal cells Research ppt
... replicationTo investigate the basis of the HSV-1-induced increase of the TAp63γ level, SIRC cells were infected in the presenceor absence of the viral DNA replication inhibitor ACG. The cells were ... reveal that the 68kDa p63 protein detected in the mock-infected SIRC cells is ΔNp63α, while the 51-62 kDa p63 isoform detected in HSV-1-infected cultures is TAp63γ.Together, these results indicate ... impres-sive reduction in the level of the ΔNp63α and a dramaticrise in the level of TAp63γ following infection with HSV-1 (Fig. 4). The kinetics of HSV-1 replication and the level of TAp63γ expression...
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Báo cáo khoa học: Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone docx
... criticalstep in bringing them to the clinical setting. Future stud-ies should focus on the quantification of the effect of these correctors on the NBD1–Hsc70 interaction in the presence of other relevant ... remains plausiblethat the F508del-induced exposure of Hsc70-bindingsites on NBD1 diminishes the ability of ATP bindingto stabilize this domain against its Hsc70 interaction.Altogether, interpretation ... 3).Analysis of the effect of adenine nucleotides on the binding of NBD1 to Hsc70To further explore the effect of adenine nucleotides on the NBD1–Hsc70 interaction, we quantified the effect of ATP...
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Báo cáo sinh học: " Possible active origin of replication in the double stranded extended form of the left terminus of LuIII and its implication on the replication model of the parvovirus" pptx
... contrib-uted in the analysis and interpretation of the data, partic-ipated in the design of the models proposed and in the drafting and revision of the manuscript.All authors read and approved the final ... (figure 1). In anticipation of the difficultiesexpected in manipulating the left end hairpin and toincrease the chances of obtaining the desired constructtwo copies of the left end termini were ... interpretation of the data, partic-ipated in the idea and design of the models proposed and in the drafting and revision of the manuscript.IDM collected the data resulting from the transfections of LuIII...
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báo cáo hóa học:" Possible active origin of replication in the double stranded extended form of the left terminus of LuIII and its implication on the replication model of the parvovirus" ppt
... capable of acting as an origin of replica-tion, lacks the arrangement of the specific domainspresent in the dimer duplex intermediate of MVM, the only active form of the left hairpin described ... (figure 1). In anticipation of the difficultiesexpected in manipulating the left end hairpin and toincrease the chances of obtaining the desired constructtwo copies of the left end termini were ... contrib-uted in the analysis and interpretation of the data, partic-ipated in the design of the models proposed and in the drafting and revision of the manuscript.All authors read and approved the final...
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Báo cáo sinh học: " The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment" docx
... Fine mapping of mutations in the fusion-inducing MP strain of herpes simplex virus type 1. Virology 1984, 136(1):100-109.19. Ryechan WT, Morse LS, Knipe DM, Roizman B: Molecular genetics of herpes ... U, Hoflack B: A tyrosine-based motif and acasein kinase II phosphorylation site regulate the intracellu-lar trafficking of the varicella-zoster virus glycoprotein I, aprotein localized in the ... but notinvolved in intracellular localization of UL20p/gK and concomitant virus-induced cell fusion. In the amino terminus of UL20, UL20p mutants were produced changing one or both of the Y38...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
... biosynthesis of natural poly-amines (putrescine, spermidine and spermine) throughconversion of l-arginine into l-ornithine [16]. The lat-ter is in turn used by ODC to produce putrescine, the precursor ... the precursor of spermidine and spermine. To further ana-lyze the regulation of the polyamine-synthetic pathway in virus infection, ODC expression in SeV-infectedJurkat cells was studied. Kinetic ... spermine enhancedvirus-induced apoptosis, annexin V ⁄ propidium iodide(PI) staining of apoptotic cells was quantified in VSV-infected Jurkat T cells in the absence or presence of spermine....
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Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... because of the attachment of the hexahistidine, the recombinantPpTGase protein appeared to be slightly larger. Theseresults indicate that the cDNA obtained covered the entirecoding region. Involvement ... 3459terminus that is required for binding to the plasmamembrane, thereby being involved in the formation of the corneum [47]. Additional amino-terminal residues of TGase 1 include the sequences ... observed in PpTGase, there might befunctional similarity between mammalian TGase 4 andPpTGase. Involvement of GTP in the function of PpTGase In the case of both TGase 2 and TGase 3, GTP inhibits the enzymatic...
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báo cáo hóa học: " Involvement of β-chemokines in the development of inflammatory demyelination" ppt
... strengthening of circulat-ing T cells to VCAM-1 on endothelial cells. Postulating the involvement of chemokines in the integrin-mediatedarrest of autoreactive T cells at the BBB, the investigators[3] ... mononuclear cells in the perivascu-lar space during the recovery phase of an acute event, andmay therefore be involved in the regulation of recoveryrather than in the initiation of the disease. In ... demyelination. This differential involvement of chemokines and their receptors in variousstages and forms of MS, and the arising information con-cerning the involvement of genetic variants of...
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Báo cáo hóa học: " The product of the Herpes simplex virus 1 UL7 gene interacts with a mitochondrial protein, adenine nucleotide translocator 2" pot
... up-regulated in proliferative cells, including several cancer cell lines, and induces apoptosisby interacting with many kinds of materials [21], includ-ing viral protein (Vpr of HIV-1 and pBI-F2 of influenzavirus) ... shows profiles of the immunoprecip-itates containing MEF-UL7 and its binding proteins in adenaturing gel. Several bands that were detected in immu-noprecipitates of the lysates of cells transfected ... experiments, which reinforced the interactionbetween UL7 and the mitochondrial protein. Together,these series of observations indicate that UL7 interactswith ANT2 in HSV-1-infected cells. The biological...
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