... [17,41].
Delineation of the basis for the differential capacity of
human leukocytes to populate the mucosal associated
lymphoid tissues of mice may provide insights into the
mechanism for lymphocyte homing ... citation purposes)
AIDS Research and Therapy
Open Access
Review
Summary of presentations at the NIH/NIAID New Humanized
Rodent Models 2007 Workshop
Har...
... involved indirectly on erythrocyte invasion. The
immune localisation of the CS-like protein described by
Cochrane et al. [12] only found at the micronemes of
merozoites of mature invasive blood ... modulate parasite development in the
sporogonic [3 - 5], exoerythrocytic [6] and erythrocytic [7]
cycle. However, there is almost no information on the
effect of antibodie...
... Mg
2+
may bind to the partially negat-
ively charged oxygen of Gln, leading to the observed effect.
Analysis of activation parameters
This analysis was based on the transition state theory of
Eyring ... k
¥
, the monopole–
monopole version of the Watkins equation was applied [30].
The Watkins equation is based on a model that assumes that
onlychargesoftheproteinattheactive...
... 8-anilino-1-naphthalenesulfonate and limited proteol-
ysis by trypsin, and by molecular dynamic simulations. The simulations
provide a first insight into the dynamics of the binary complex with ATP,
including motion of the ... Combined with enzyme kinetic analyses, our data indicate that
the ATP-induced changes in protein conformation may have implications
for the kinetic coope...
... activation pathway to test whether activation by
methyl epoxyfarnesoate treatment was actually dependent
on the presence of wild-type USP. As shown in Fig. 4C, the
activation of the 4DR12Core ... activate transcription in
methyl epoxyfarnesoate-treated cells is the first such iden-
tification of the activating binding of any compound,
natural or synthetic, to the ligand-bind...
... slow, but ultimately tight, binding
of PLP to the apoenzyme in vitro and for the fact that
preparations of the mutant enzymes are always largely as
apoenzyme. Similarly, inflexibility of the protein ... correspond-
ingly, the amount of PLP released by NaOH treatment was
only 10% of that expected for a fully saturated holoenzyme.
Nevertheless, the small amount of cofacto...
... DNA thermal cycler (MWG Biotech,
Milton Keynes, UK) with the use of the following cycling
parameters: an initial denaturation step at 92°C for 2 minutes,
followed by 30 cycles of denaturation at ... immunity [5].
One of the major problems in accurately determining the infec-
tion rate is the difficulty in isolating, by traditional culture meth-
ods, the bacteria from th...
... activated by three pathways:
the classical pathway and the lectin pathway both require the
fourth component of complement (C4), while the alternative
pathway is independent of C4. All three pathways ... classical pathway hemolytic activity. Given that
immune complex renal injury in the MRL/lpr mouse is
independent of Fc receptors as well as the major negative
regulator of...
... are
made at the diaphyseal part of the metacarpal bones [5,6].
DXR in rheumatoid arthritis
Patients with RA often exhibit an accelerated course of
progression during the early years of disease, and therefore ... The computer algorithms
employed in the DXR technique automatically define regions
of interest around the narrowest parts of the second, third
and fourth met...