The Biology of NKT Cells Albert Bendelac - part 3 pptx
The Biology of NKT Cells Albert Bendelac - part 3 pptx
... only.ANRV306-IY2 5-1 2 ARI 11 February 2007 12:2049. Yamaguchi Y, Motoki K, Ueno H, Maeda K, Kobayashi E, et al. 1996. Enhanc-ing effects of (2S,3S,4R )-1 -O-(α-D-galactopyranosyl )-2 -( N-hexacosanoylamino )-1 ,3, 4- octadecanetriol ... constitutiveautoreactive recognition of iGb3 through the secretion of IFN-γ (indirect microbial recognition).www.annualreviews.org• Biology of NKT Cells 31 7Annu. Rev. Immunol. 2007.25:29 7 -3 36 . Downloaded from ... Smyth MJ, Van Kaer L. 2004. NKT cells: What’s in a name? Nat. Rev. Immunol. 4: 231 37 www.annualreviews.org• Biology of NKT Cells 32 3Annu. Rev. Immunol. 2007.25:29 7 -3 36 . Downloaded from arjournals.annualreviews.orgby...
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The Biology of NKT Cells Albert Bendelac - part 1 ppsx
... by the rar-ity of iGb3 and the dominance of the regioiso-mer Gb3. Furthermore, other than the enzy-matic pathways of synthesis and degradation,little is known about the general biology of iGb3, ... wall of Sph-ingomonas, a Gram-negative, LPS-negativemember of the class of α-proteobacteria ( 53, 54). These glycosphingolipids are responsi-ble for the strong stimulation of NKT cells and their ... by the mannose re-ceptor langerin (98, 99) or can insert them-selves directly in the outer leaflet of the www.annualreviews.org• Biology of NKT Cells 30 5Annu. Rev. Immunol. 2007.25:29 7 -3 36 ....
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The Biology of NKT Cells Albert Bendelac - part 2 pdf
... by the autoreac-tive IL-2 response of NKT hybridomas toDP thymocytes (18) and by the proliferativeand cytokine response of fresh NKT cells tosynthetic iGb3 (26). The other reason is that the ... difference between the development of NKT cells and that of conventional T cells. Furthermore, during these stages a DN pop-ulation arises by downregulation of CD4 in 30 %–50% of the cells, as shown ... ANRV306-IY2 5-1 2 ARI 11 February 2007 12:20pathways overlap only partially with thosegoverning the trafficking of endogenous gly-cosphingolipids, which are synthesized in the lumenal part of the...
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The Biology of NKT Cells Albert Bendelac - part 4 ppsx
... for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 278:16 23 26196. Park SH, Kyin T, Bendelac A, Carnaud C. 20 03. The contribution of NKT cells, NK cells, and other γ-chain-dependent ... ExtravascularT-cell recruitment requires initiation begun by Vα14+ NKT cells and B-1 B cells. TrendsImmunol. 25:441–49www.annualreviews.org• Biology of NKT Cells 33 5Annu. Rev. Immunol. 2007.25:29 7 -3 36 . ... diverse mouse models of glycosphingolipid lysosomalstorage diseases. J. Exp. Med. 2 03: 22 93 30 3www.annualreviews.org• Biology of NKT Cells 32 7Annu. Rev. Immunol. 2007.25:29 7 -3 36 . Downloaded from...
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THE ROLE OF SURGERY IN HEART FAILURE - part 3 pptx
... across a prosthetic valve depends upon the type,size, and position of the prosthesis as well as the cardiac output; guidelines are available for the ac-ceptable range of Doppler gradients ... Assessment of mechanicalprosthetic malfunction is more difficult with TTEbecause acoustic shadowing caused by the pros-thetic material may limit transthoracic visualiza-tion of prosthetic leaflets, ... leaflet tear of bioprosthesis,and leaflet calcification/stenosis of bioprosthesis.Because of its more anterior position, aorticprosthesis can be imaged more efficiently by TTEthan mitral prosthesis....
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The Nature Of Design - Oxford University Press - Part 2 pptx
... erosion. The speed of the horse, in otherwords, allows the Amish to pay attention to the minute particulars of their farm and how they farm. By a similar logic, he waits to cut hayuntil the bobolinks ... wisdom. In large part the difference, whetherthey thought about it or not, was the speed of the society.It is time to consider the possibility that, for the most part, com-munication ought ... a pal-try work of conscious purpose, at the service and the mercy of expe-dient aims” (19 83, 33 ). Our experience of an increasingly uniformand ugly world is being engineered and shrink-wrapped...
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The Nature Of Design - Oxford University Press - Part 3 docx
... condition andweaken the public mind. The exercise of their economic power cre-ates dependencies that undermine public resolve. Their sheer perva-92 THE POLITICS OF DESIGN the terms of the law should ... and the poor. They cannot find the wherewithal to defend the public in-terest in matters of global trade or even in the financing of public elec-11Conservation and Conservatism The philosophy of ... ignored. In the fall of 1994, about the same time that Easterbrook would have been work-ing over the galley pages for his book, agents of the Republican partywere drafting the final version of The Contract...
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Chapter 064. The Practice of Genetics in Clinical Medicine (Part 1) pptx
... limitations of genetic testing in the management of Chapter 064. The Practice of Genetics in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 64. The Practice of Genetics ... for example, the concordance rate in monozygotic twins ranges between 50 and 90%. Diabetes or impaired glucose tolerance occurs in 40% of siblings and in 30 % of the offspring of an affected ... or in combination with other genes or environmental factors. Our understanding of the genetic basis of these disorders is incomplete, despite the clear recognition of genetic susceptibility....
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Chapter 064. The Practice of Genetics in Clinical Medicine (Part 2) pptx
... members. The determination of risk for an asymptomatic individual will vary depending on the size of the pedigree, the number of unaffected relatives, and the types of diagnoses, as well as the ... mutations would greatly impact the cost of testing without significantly influencing the effectiveness of mass screening. Nevertheless, the individual who carries one of the less common cystic fibrosis–associated ... of her family history. When assessing the personal and family history, the physician should be alert to a younger age of disease onset than is usually seen in the general population. A 30 -year-old...
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