The Biology of NKT Cells Albert Bendelac - part 1 ppsx

... mouse (14 ) and with the ho-mologous Vα24-J 18 /V 11 pair in human (14 , 15 ). The finding that the mouse and hu-man NKT cells were autoreactive to cells expressing CD1d (15 18 ), a member of the CD1 ... by the rar-ity of iGb3 and the dominance of the regioiso-mer Gb3. Furthermore, other than the enzy-matic pathways of synthesis and degradation,little is known about the general biology of iGb3, ... receptors, in-cluding NK1 .1 in the C57BL/6 background,in addition to semi-invariant CD1d-restrictedαβ TCRs. More than 80% of these TCRsare V 14 -J 18 /Vβ8, Vβ7, and Vβ2 in mouse(or Vα24-J 18 /V 11 in...

... for V 14 NKT cells in IL -1 2 -mediated rejection of tumors. Science 278 :16 23–26 19 6. Park SH, Kyin T, Bendelac A, Carnaud C. 2003. The contribution of NKT cells, NK cells, and other γ-chain-dependent ... modified glycolipid-stimulated NKT cells. J. Clin. Invest. 11 3 :16 31 40 18 7. Eberl G, MacDonald HR. 19 98. Rapid death and regeneration of NKT cells in anti-CD3epsilon- or IL -1 2 -treated mice: a ... non-T non-B cells to IL -1 2 -mediated rejection of tumors. J. Immunol. 17 0 :11 97–2 01 197. Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, et al. 2002.CD1d-dependent macrophage-mediated...

... the IL-2Rβ component of the IL -1 5 receptor, which is important for the survival of CD44highNK1 .1 negand terminallydifferentiated CD44highNK1 .1 pos cells (16 0– 16 2). However, the range of ... DPDNCD4CD4DNCD4DNV 14 -J 18 CD24hiCD69hiCD24loCD44loNK1 .1 –IL-4CD24loCD44hiNK1 .1 –IL-4IFN-γCD44hiNK1 .1 +IL-4IFN-γEmigrantFigure 4Thymic NKT cell development. NKT cell precursors ... tetramersspecific for the canonical V 14 TCRs (11 7– 11 9) has transformed this area of study byallowing the identification of developmen-tal steps independently of the expression of NK1 .1 (Figure 4). The first...

... et al. 19 96. Enhanc-ing effects of (2S,3S,4R ) -1 -O-(α-D-galactopyranosyl )-2 -( N-hexacosanoylamino ) -1 ,3, 4- octadecanetriol (KRN7000) on antigen-presenting function of antigen-presenting cells and ... role of Vα24 NKT cells in hepatitis C (85) and the accumulation of non-Vα24 CD1d-restricted T cells ( 210 ). Al-though a specific role of V 14 NKT cells in HSV infection remains controversial ( 211 , 212 ), ... population of CD1d-restricted T cells in mouse is the NKT cell population that expresses semi-invariantTCRs, predominantly V 14 -J 18 , and per-forms innate-like functions (19 ). The pres-ence of a...

... limitations of genetic testing in the management of Chapter 064. The Practice of Genetics in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 64. The Practice of Genetics ... or in combination with other genes or environmental factors. Our understanding of the genetic basis of these disorders is incomplete, despite the clear recognition of genetic susceptibility. ... Despite the fact that diabetes affects 5% of the population and exhibits a high degree of heritability, only a few genetic mutations (most of which are rare) that might account for the familial...

... 10 /11 - 11 /12 10 /11 - 12 /13 best motor learning aptitudeEarly youth (pubescence) 11 /12 - 13 /14 12 /13 - 14 .5 restructuring kinetic skills and proficien-ciesLate youth (adolescence) 13 /14 - 17 /18 ... movementsToddler 1. 1 - 3.0 adopting manifold movement patternsEarly childhood 3 .1 - 6/7 perfectioning of manifold movement patterns and adoption of first combined movementsMedium childhood 7 .1 - 9 /10 fast ... iÀÊ-VÕ/iÊ>ÃV>ÌÊvÊÕÌ>Ìi`Ê>`}Ê/>ÃÃÀ««iÀÃÊÊÌ 1. 1 The Handling Process The process of handling component parts or workpieces in produc-tion is often underrated as technically simple or even trivial. From the production point of view...

... 1, 370NPGNPGN-plus20 011 983 19 85 19 87 19 89 19 91 1993 19 95 19 97 19 99 2003By comparing three parallel jaw grippers at various stages of devel-opment, the efficiency increase can be illustrated (see figure 2.3). The standard ... offered by SCHUNK in 19 83 already had very good ratios at the time. The force/weight ratio, i. e. the grip-ping force in relation to the weight of the gripper multiplied by the stroke of the ... t λ 1 - 2Nmkg39Handling: The Underrated Process 1. 3 What Are The Main Points of This Book? The following chapters focus on the realization of handling technol-ogy tasks. Keynote is the...

... than in the other examples. Form-fit gripping in the direction of accelera-tion and of gravity is provided in the second example. The gripper must counteract the force which stretches the gripper ... 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