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Introduction to Medical Immunology - part 6 ppt

Introduction to Medical Immunology - part 6 ppt

Introduction to Medical Immunology - part 6 ppt

... MHC-II+ macrophagesE. RF-producing plasmablasts21.8 Which one of the following cytokines is usually undetectable in rheumatoid synovial fluid?A. GM-CSFB. IL-2C. IL-4D. IL-8E. Interferon-γ21.9 ... of vascular hyper- Page 39921 Rheumatoid ArthritisJean-Michel GoustI. Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammatory and degenerative ... high titers of antinuclear factorE. Suggestive of a drug-induced etiologyQuestions 20.2–20.3 refer to the following case history: A 28-year-old woman has a history of weight loss, intermittent...
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Introduction to Medical Immunology - part 5 ppt

Introduction to Medical Immunology - part 5 ppt

... have been used to induce tolerance in laboratory animals. It is possible that such peptides are able to bind directly to MHC-II molecules and may deliver tolerogenic signals to T lymphocytes ... anti-idiotypic responses to autoimmunity postulates that autoreactive cells are stimulated by anti-idiotypic antibodies emerging in the wake of an anti-infectious response, due to the cross-reactivity ... family, such as ICAM-1, ICAM-2 and VCAM-1, expressed on the endothelial cell membrane. 6. Cytokines released by activated monocytes and lymphocytes, such as IL-1 and TNF-α can up-regulate the expression...
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Introduction to Medical Immunology - part 1 pot

Introduction to Medical Immunology - part 1 pot

... Microbiology and Immunology, Medical University of South Carolina, Charleston, South CarolinaJean-Michel Goust, M.D. Professor of Immunology, Department of Microbiology and Immunology, Medical University ... Education, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.An-Chuan Wang, Ph.D. Professor, Department of Microbiology and Immunology, Medical ... predominant helper function from those with predominant cytotoxic function.e. T-cell mediated cytotoxicity is an apoptotic process that appears to be mediated by two separate pathways. One involves...
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Introduction to Medical Immunology - part 2 potx

Introduction to Medical Immunology - part 2 potx

... CD40 ligand (CD40L, CD154, gp39), LFA-1 and ICAM-1. These molecules have counterparts on the APC: CD58 (LFA-3), CD80/ 86, CD40, ICAM-1, and LFA-1 (ICAM-1 and LFA-1 are expressed in both cell populations ... the ability to bind to high-affinity Fcε receptors) after heating at 56 C for 30 minutes. This binding depends on the tertiary structure of the C-terminal portion of Cε2 and the N-terminal ... useful to assay human secretory IgA in secretions?A. Anti-IgA1 antibodiesB. Anti-IgA2 antiserumC. Anti-J chain antibodyD. Anti-kappa light chainsE. Anti-secretory component5.2 Which of...
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Introduction to Medical Immunology - part 3 ppsx

Introduction to Medical Immunology - part 3 ppsx

... of12345 6 789Antibody - - - - +++++Antigen++± - - - - - - (+ means visible precipitation; - means no visible precipitation)What tube(s) correspond to the antigen excess zone:A. 1 to 3B. 1 to 4C. 4D. 4 to 9E. 5 to 98.2 Using ... stages of CD8-mediated cytotoxicity?A. CD2 : CD58 (LFA-3)B. CD8 : MHC-IC. CD95 (Fas) : Fas ligandD. IL-2 : IL-2RE. Interferon-γ (IFN-γ) : IFN-γR11.3 The development of antigen-specific ... with B-cell activation. Conversely,Page 213IL-4 and IL-10 may play a role in suppressing TH1 responses by down-regulating IL-12 synthesis. Other cytokines, such as transforming growth factor-β...
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Introduction to Medical Immunology - part 4 pps

Introduction to Medical Immunology - part 4 pps

... IL-2, interferon-γ, lymphotoxin (TNF-β), and TNF-α.c. Patients infected by bacteria able to release large amounts of superantigens (e.g., S. aureus-releasing enterotoxins or TSST-1 ... and human T lymphocytes, inducing T-cell proliferation and cytokine release. TSST-1 also appears to activate monocytes and is a potent B-cell mitogen, inducing B-cell proliferation and differentiation.4. ... releases significant amounts of toxinC. Facilitating the onset of a recall response to the toxinD. Inhibiting the binding of the toxin to its receptor by blocking the toxin's active siteE....
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Introduction to Medical Immunology - part 7 pps

Introduction to Medical Immunology - part 7 pps

... exposure to IgG anti-D antibodies is due to: A. Complement activationB. Fc-mediated phagocytosisC. C3b-mediated phagocytosisD. C3d-mediated phagocytosisE. A combination of Fc and C3b-mediated ... and 25.10 refer to the following case:A 3 6- year-old woman with a history of drug abuse, hepatitis C, and treatment with IFN-γ (6 months prior) presents with recent proven streptococcal throat ... (Ag 2-3 .Ab 2 -6 ), particularly when involving complement-fixing antibodies (IgG1, IgG3) of moderate to high affinity. However, a main question that needs to be answered is how these IC diffuse into...
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Introduction to Medical Immunology - part 10 doc

Introduction to Medical Immunology - part 10 doc

... 470diagnosis, 269 mechanisms, 420target tissue, 364 warm antibody type, 46 5-4 66 , 467 case example, 465 , 470cold agglutinin disease/syndromes, 46 6- 4 67 , 560 cold-induced, 560 drug-induced, 46 7-4 70Hemolytic ... assays, 30 5-3 06 Mitogens, 305Mitosis, in CD4+ activation, 19 4-1 95Mixed-lymphocyte cultures, 519Mixed-lymphocyte reaction (MLR), 6 4 -6 5, 30 9-3 11MLR (mixed-lymphocyte reaction), 6 4 -6 5, 30 9-3 11Molecular ... 4 56, 463 , 465 , 467 indirect, 269 , 4 56, 457Copolymer-1 (COP-1; copaxone), 378Co-receptors,addition of, 16 8-1 69 association with, 164 TcR2, 177in TcR complex, 175Cortex,of lymph node, 16 Page...
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introduction to medical immunology

introduction to medical immunology

... associations of MHC-I and non-self peptides; occupancy of the binding site on the TcR by MHC-I-associated peptide provides the antigen-specific signal that drives cytotoxic T cells.4. Cytotoxic T lymphocytes ... interaction of CD8 with MHC-I, CD2 with CD58 (LFA-3), LFA-1 with ICAM family members, and CD28 with CD80 and CD 86, to name a few. 6. The expansion of antigen-activated cytotoxic T lymphocytes requires ... differentiate.a. The IL-2 receptor is up-regulated and increases its affinity for IL-2; consequently, IL-2 participates in autocrine and paracrine signaling, which results in T-lymphocyte proliferation.b....
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Vault Career Guide to Investment Banking Part 6 pptx

Vault Career Guide to Investment Banking Part 6 pptx

... companyaiming to go public. The S-1 is almost identical to the prospectus sent to potential investors. The SEC must approve the S-1 before the stock can besold to investors. S-2: A type of ... ratio: The price -to- earnings ratio. This is the ratio of a company’sstock price to its earnings-per-share. The higher the P/E ratio, the moreexpensive a stock is (and the faster investors believe ... 7,000,000I-Bank 2 (a co-manager) 4,000,000I-Bank 3 (a co-manager) 4,000,000I-Bank 4 294,118I-Bank 5 294,118• • • • • • • • I-Bank 20 294,118TOTAL 20,000,000Vault Career Guide to Investment...
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