... individual loci driving
variation in both methylation and expression.
To better understand the role of genetic variation in
controlling DNA methylation variation, and its resulting
effectsongeneexpressionvariation, ... data taking
into account DNA methylation, in only 10% of eQTLs
was the gene tic effect of the SNP on expression affected
by controlling for met...
... (cytokine–cytokine receptor interac-
tions). The mean gene expression (blue line) and the intra-group inter-individual variances in RA and NC synovial membrane (red bar) are indicated,
resulting in ... significantly affected by
higher gene expression variances were identified in RA
compared with NC, including cytokine–cytokine receptor
interactions, the transforming growt...
... 30 days before conception and six months
post-delivery. In the first analysis, cases were defined
as boys with hypospadias recorded in the HDR
during the first six months post-delivery.
The ... number, and the date of
drug dispension. Since January 1 1989 all data from
North Jutland County have been stored in a
prescription database maintained by the Department
of Clinical...
... cleavages in the interdomain and autolysis loops
in the inactivation of chymotrypsin. At first, D-chymo-
trypsin and the interdomain and autolysis loop mutants were
subjected to digestion with trypsin. ... trypsin mutant with chymotrypsin-like activity (Table 1)
was subjected to autolysis and digestion with D-chymo-
trypsin and trypsin. Interestingly, despite the presence o...
... Spanish-sounding words occasionally and spon-
taneously coming to his mind. No meaning is associated
with these words and the patient easily controls their
occurrence with no anxiety. Neurological examination
completed ... seen on the brain imaging, involving the left insular and
anterior temporal cortex, two brain regions frequently involved in aphasic syndrome but also in
FAS,...
... cannot stay
still for long' and 'I am constantly fidgeting or squirming'.
These findings indicated that the aforementioned items
create a subdimension within the hyperactivity/inatten-
tion ... divided into two subdimensions
(that is, hyperactivity and inattention). This finding may
reflect the inability to assess the multidimensional atten-
tion deficit hyperactivity disor...
... metalloproteinase (MMP)
expression and activation in the medium were analysed by
gelatin zymography, proteoglycan release by the
dimethylmethylene blue assay, and cell viability by the
Cytotox 96
®
assay. ... primary chondrocytes and chondrocyte cell lines results
in increased apoptosis and caspase activity [43,44]. Since
we have previously shown that TNF-α increases PACT
pr...
... IL-16 and
RANTES in RASFs provoking chemoattraction of T cells.
The data demonstrate, for the first time, a bridging link
between B -cell activity and T -cell trafficking. In addition,
they are ... RA. They demonstrate clearly that
antibodies may interact directly with fibroblast-like cells
and through this interaction form part of a signalling loop
that ultimately results in...
... MMP-3
and MMP-13 in human and bovine chondrocyte cell lines
IL-1β potently induced expression of the genes encoding
MMP-3 and MMP-13 in the human chondrocytic cell line
SW1353 and in primary human ... prevents the binding of Sp1 to its cognate
DNA [19]. MMP-3 and MMP-13 induction by the three major
inflammatory cytokines and inhibition by mithramycin imply that
inter...