Báo cáo y học: "Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencin" ppt

... to common tumor suppressor genes shared by many cancer types likeRB1 and TP53, many tumor suppressor genes are specificto a particular tumor type and/ o r cell type that originate the tumor. Deficiency ... 11:R114http://genomebiology.com/2010/11/11/R114Page 4 of 14RESEARC H Open AccessSystematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencingQi ... HCC1954 and HCC1954BL, which comprise5.4% and 2.6% of genes surveyed, respectively. Many of these genes identified by loss of heterozygosity and allele-specific expression are kno wn or putative tumor...

Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx

... of the drug is hydrogen-bonded to the two O2 atoms of the thymine bases of the central AT steps. Nitrogen atomsN3(D) and N7(D) bridge N3(adenine) and O2(thymine)atoms of opposite strands. Furthermore, ... amino-grouppyramidalization. The contacts of the atoms O1(D) and N1(D) at the otherside of the drug are more complicated. The interactionenergy with A5 of )19.6 kJÆmol)1is close to those of awater dimer. Combined ... noncovalently in the minor groove of DNA with abinding preference for stretches of AT-rich sequences [1],thereby preventing DNA and RNA synthesis by inhibition of the corresponding polymerase reaction....

Báo cáo y học: "Hereditary angioedema: beyond international consensus - circa December 2010 - The Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie Lecture" pps

... teaching in the field of Allergy and Clinical Immunology and was well respected as aphysician, teacher and colleague. The 2010 Canadian Society of Allergy and Clinical Immunology Dr. David McCourtie ... trials and other studies published oneither prophylaxis or therapy of hereditary angio edema and some of these produ cts have changed licensure sta-tus in various countries. With publication of these ... type III HAE) with the defec ts yetto be identified. The pathophysiology of HAE-C1INHtypes I and II appears to relate to bradykinin resultingin angioedema. HAE may present under one year of...

Báo cáo y học: "4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase" doc

... articular chondro-cytes and as the main precursor for the synthesis of ECM gly-cosaminoglycans in cartilage [35,36]. The inhibition of proteoglycan synthesis in OA chondrocytes by HNE (data notshown) ... activity is primarily impor-tant for the observed event. On the other hand, the inhibition of mNADP+-ICDH, an important regulator of the citric acidcycle, by HNE supports the role of this aldehyde ... goal of clarifyingthis role, we documented the ability of HNE to modulate mark-ers of apoptosis, redox status, and energy metabolism of chondrocytes. Then, we investigated the potential role of...

Báo cáo y học: "Introducing Arthritis Research & Therapy’s 10th anniversary issue, ‘The Scientific Basis of Rheumatology: A Decade of Progress’" pdf

... gives the reader the advantages of a traditional review text.Overview of part one of The Scientific Basis of Rheumatology: A Decade of ProgressBiology and methodology The contribution of Foxwell ... arthritis. Chen and Tuan [2] discuss the potentialinvolvement of MSCs in the pathophysiology of degenerativejoint disease and explore the prospects of MSC-basedtherapies for these common rheumatic ... rheumatology. In 2003, the name of the journal was changed to Arthritis Research & Therapyto denote the journal’s aim of incorporating translationalaspects of rheumatology within its pages.In the...

Báo cáo y học: " Adjuncts or adversaries to shared decision-making? Applying the Integrative Model of behavior to the role and design of decision support interventions in healthcare interactions" pps

... contextsover the past 30 years. [21]. These include the Theory of Reasoned Action, the Theory of Planned Behavior, the Health Belief Model and Social Cognitive Theory. [31-34].Implicit in the combination ... askingquestions? Finally, self-efficacy reflects whether a personperceives that they have the necessary skills and abilitiesto perform the behavior if they really want to do so. Each of these primary constructs ... patient side of the clinical dyad.How behavioral theory can guide the development of interventions to increase shared decision-making The field of psychology has developed a large body of the- oretical...

Báo cáo y học: "CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion" ppt

... conceived the study, carried out the in vivo experi-ments and flowcytometry, performed the statistical analy-sis and drafted the manuscript. FR participated in the design and coordination of the ... Offringa and has been described previously [14]. The 9H10 antibody was administered as 100 µg/mousei.p. on the first day together with DC vaccination and 50µg/mouse i.p. on the third and fifth day. ... RE, Offringa R, Melief CJ: Syner-gism of cytotoxic T lymphocyte-associated antigen 4 block-ade and depletion of CD25(+) regulatory T cells in antitumortherapy reveals alternative pathways for...

Báo cáo y học: "Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis" pdf

... study is under way.Introduction The prevalence of systemic lupus erythematosus (SLE) varieswith age, gender, and ethnicity, and the highest rates occur inyoung adult women, particularly of ... 2 g daily. The duration of follow-up of patients on MMF was generallybetween 6 and 36 months, and average follow-ups were gen-erally of 1 year or longer. None of the studies clearly indicatedthat ... from the origin of the study; of 161 patients, 95 were white, 46 black, and 20other.Doses of MMF were between 125 mg and 3 g daily, but aver-age or median doses were generally between 1 and...

Báo cáo y học: "Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action" pot

... underestimate because our cur-rent analysis is limited by the quality and quantity of the therapeutic data available. Our representations of chemi-cal structure and drug therapeutic use rely on publicdatabases, ... struc-tural similarity (295 and 37 pairs in the heterozygous and homozygous datasets, respectively). Of these pairs, 74% and 90% in the heterozygous and homozygous datasets,respectively, did not share ... To deter-mine the best representation of co-fitness of two genes (the similarity of their fitness profiles), we tested severalscore types and similarity metrics. The score typesincluded log2...

Báo cáo y học: "Phylogenetic detection of numerous gene duplications shared by animals, fungi and plants" ppsx

... suggested by the ‘ crown-stem’ model [18-20]. Even if the position of the root of the eukaryotic tree is between Excavata and the other supergroups, the split of the lineage withplants and the lineage ... leading to the conclusion thatearly eukaryotes had significantl y more gene duplicatio nFigure 1 Alternative views of the eukaryotic phylogeny and the design of phylogentic analysis. (a) The ‘crown-stem’ ... USDepartment of Energy (DE-FG02-02ER15332), the Biology Department, the Eberly College of Sciences, and the Huck Institutes of the Life Sciences, the Pennsylvania State University. XZ was supported...

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