... beenexamined. This nucleotide sugar is generated de novofrom GDP-Man in three steps catalysed by two cytoso-lic enzymes: GDP-mannose dehydratase (GMD; EC4.2.1.47) and GDP-keto-6-deoxymannose 3,5-epi-merase ... stainKeywordsCaenorhabditis; Drosophila; GDP-fucosebiosynthesis; GDP-keto-6-deoxymannose 3,5-epimerase ⁄ 4-reductase; GDP-mannosedehydrataseCorrespondenceI. B. H. Wilson, Department fu¨r Chemie,Universita¨tfu¨r ... Sturla L, Etzioni A, Bisso A, Zanardi D, De Flora G,Silengo L, De Flora A & Tonetti M (1998) Defectiveintracellular activity of GDP-D-mannose-4,6-dehydra-tase in leukocyte adhesion de ciency...