...
First,
we
will
discuss
heritability
estimates
of
body
weight
and
weight
gain.
The
heritability
estimates
of
body
weight
and
weight
gain
as
summarized
by
Kinney
(1969)
ranged ...
Heritability
estimates
and
types
of
gene
action
of
some
economic
traits
in
&dquo;Dokki
4&dquo;.
II.
Heritability
and
types
of
action
on
8
and
12...
... (IR) and adapt
it to the domain of sentiment classification.
3.1 The classic tf.idf weighting schemes
The classic tf.idf formula assigns weight w
i
to
term i in document D as:
w
i
= tf
i
· idf
i
= ... hand, using
idf to assign weights to features is less intuitive,
since it only provides information about the gen-
eral distribution of term i amongst documents of
all class...
... transcription
initiation of genes, initiation of DNA replication and
alternative splicing of exons. The small interference
(si)RNA genes active in RNA interference comprise
inverted repeats capable of forming ... candidates with a threshold score of 8, and
found that 267 of the LIRs are potential siRNA genes.
The validity of these motifs in gene silencing requires
further em...
... NS2B–NS3pro is nontrivial. In one study,
competitive inhibitors with an inhibition constant of
3 lm were found and their binding to WNV NS2B–
NS3pro modelled [11]. In another, noncompetitive
inhibitors ... in the absence of inhibitor [4] and in the
presence of peptide inhibitors [5,6] or bovine pancre-
atic trypsin inhibitor (BPTI) [4]. In the absence of
inhibitor, the structur...
... infrequently and since one of the major foci
of the study was to try to find general means of
deciding attachment of PPs, individualization of
these PPs was, at first, discounted. In some of
the prior ... definite, indefinite, generic,
and generic plural noun phrases (Crain and Steed-
man 1984). In a streamlined version of the theory
(Hirst 1987), definite noun phra...
... compilation ª 2009 FEBS 2163
MINIREVIEW
A study of microRNAs in silico and in vivo: diagnostic and
therapeutic applications in cancer
Scott A. Waldman
1
and Andre Terzic
2
1 Departments of Pharmacology ... observations highlight
the potential of miRNAs as biomarkers for diagnosis,
taxonomic classification, prognosis, risk stratification
and prediction of therapeutic responses...
... networks in disease and after applica-
tion of a variety of therapeutic strategies. Critically,
the noninvasive imaging approach of miRNA genera-
tion and its activity will improve our ability to diag-
nose ... [11]. Therefore,
a variety of imaging strategies, showing each step in
the generation of miRNAs, will provide critical
Bioimaging of miRNA biogenesis and regulation S...
... and the heights, widths and positions of
each band were optimized successively. Data treatment and
band decomposition of the original amide I or amide I
regions have been described previously [29,32,54]. ... 32.
Derivation gave the number and position, as well as an esti-
mation of the bandwidth and the intensity of the bands
making up the amide I or I region. Thereaf...
... Jr
(2004) 1-Chicoric acid inhibits human immunodeficiency
virus type 1 integration in vivo and is a noncompetitive
but reversible inhibitor of HIV-1 integrase in vitro.
Virology 326, 203–219.
34 King PJ, ... the main limiting step for mul-
tiple turnover. First, it is unlikely that DNA binding is
limiting even if it is slow. This step is responsible for
the sigmoidal shape of the product...
... the
dimers and, (b) they provide criteria for the design of
experiments to probe the functional effects of dimeriza-
tion ⁄ oligomerization on mechanisms of ligand binding
and extent of activation ... involved in
dimerization ⁄ oligomerization interfaces. This finding is
intriguing given the recent experimental data suggest-
ing a role for precisely TM1 and TM4 in the dimeri-
zati...