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Báo cáo y học: "Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts" ppt

Báo cáo y học:

Báo cáo y học: "Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts" ppt

... is properly cited.ResearchDetection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcriptsMeryem ... exists in Y. lipolytica, but some effectors are lackingThe presence and efficiency of NMD was investigated in Y. lipolytica. Homologs of UPF1 (YlUPF1,YALI0D23881g) and UPF2 (YlUPF2, YALI0E24629g)were ... degradation by the nonsense-mediated mRNA decay (NMD) machinery. In Y. lipolytica, homologs of S. cerevisiae UPF1 and UPF2 genes were identified, but not UPF3. The inactivation of Y. lipolytica UPF1 and...
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Báo cáo y học:

Báo cáo y học: "Cross-sectional analysis of adverse outcomes in 1,029 pregnancies of Afro-Caribbean women in Trinidad with and without systemic lupus erythematosus" ppsx

... granted by the Ethics Committee of theLondon School of Hygiene & Tropical Medicine and by theMinistry of Health of the Republic of Trinidad & Tobago. Allparticipants provided informed ... diseaseactivity and comorbidity in Trinidad. Furthermore, termination of pregnancy is currently illegal in Trinidad and therefore islikely to have been misreported as miscarriage – combinedwith ... using different markers of socioeconomic sta-tus, including years of education and district of residence. Theunit of analysis was a pregnancy. The association between therelevant pregnancy...
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Báo cáo y học:

Báo cáo y học: "Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates" docx

... adisintegrin and metallopeptidase domain (ADAM) 1, 3,5, and 26 - have the metalloendopeptidase activity. Pro-tein domain analysis shows that two Pfam domains -reprolysin family propeptide and ... human lineage.Conclusions: This analysis of unitary pseudogenes provides insights into the evolutionary constraints faced bydifferent organisms and the timescales of functional gene loss in humans.BackgroundPseudogenes ... 75 million years ago. In total, we identify 76 unitarypseudogenes, including previously annotated ones, and many novel ones. By comparing each of these to itsfunctioning ortholog in other mammals,...
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Báo cáo y học:

Báo cáo y học: " Detection and correction of false segmental duplications caused by genome mis-assembly" potx

... in that region.SNPs and insertions/deletions (indels) are valuable formany reasons, including genotyping, evolutionary analysis, and the relation of genotype to phenotype [18,41,42]. Forexample, ... assembly.Kelley and Salzberg Genome Biology 2010, 11:R28http://genomebiology.com/2010/11/3/R28Page 6 of 11visually inspected and, in most cases, one copy wasremoved [38]. In the assembly of ... tomis-assembly, and in this paper we attempt to identify and quantify the frequency of this type of assembly error. Toaccurately detect mis-assembled haplotype sequence, weincorporate the reads'...
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Báo cáo y học:

Báo cáo y học: "Sequencing and analysis of an Irish human genome" ppt

... Coloproctology,Institute of Genetics and Molecular Medicine, University of Edinburgh,Edinburgh, EH4 2XU, UK.4Department of Clinical Neurological Sciences,Royal College of Surgeons in Ireland, Dublin 2, Ireland.5School ... Hospital and Trinity College Dublin,Beaumont Road, Dublin 9, Ireland.8School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.9Centre ... sequence her-alded a landmark in human biology [1]. By mapping outthe enti re genetic blueprint of a human , and as the cul-mination of a decade long effort by a variety of centers and laboratories...
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Báo cáo Y học: Phosphorylation and dephosphorylation of histidine residues in proteins Susanne Klumpp and Josef Krieglstein Abteilung Biochemie und Institut fu¨r Pharmakologie und ppt

Báo cáo Y học: Phosphorylation and dephosphorylation of histidine residues in proteins Susanne Klumpp and Josef Krieglstein Abteilung Biochemie und Institut fu¨r Pharmakologie und ppt

... histidine. The serine/threonineprotein phosphatases type 1, t ype 2 A a nd type 2C, in contrast, a re highly active against phosphohistidine in histone H4 (reviewed in [1]). Intriguingly, none of ... appearance and disappearance of phos-phohistidine on P-selectin are very rapid.The next finding of an intracellular signaling systeminvolving histidine phosphorylation in mammals appeared in 2000 ... 1071 In addition to well known phosphorylation on serine,threonine and tyrosine residues, thrombin and collagen leadto the phosphorylation of histidine in the cytoplasmic tail of P-selectin....
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Báo cáo sinh học:

Báo cáo sinh học: "Detection and characterization of translational research in cancer and cardiovascular medicine"Ơ docx

... structures, policy initiatives, or clinical concerns?Dev elopments in cancer research in the 1990s, includingrapid advances in understanding of cancer genetics and increasing use of surface antigens ... Specifically, inter-citation analy sis in 1980 revealed tw o distinct domains,one focused on basic science and one on clinical oncol-ogy. By 2000 a distinct third domain had appeared. Ithad strong internal ... ranslational research ishappening, and why, so that they can formulate and testpolicy innovations that might foster it. Unfortunately,defining translational medicine and assessing its impacthas been...
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báo cáo hóa học:

báo cáo hóa học:" Detection and characterization of translational research in cancer and cardiovascular medicine" potx

... understanding of cancer genetics and increasing use of surface antigens to characterize celltypes, yielded a hybrid of applied and basic research withclear relevan ce for clinical oncol ogy. Cardiac ... Specifically, inter-citation analy sis in 1980 revealed tw o distinct domains,one focused on basic science and one on clinical oncol-ogy. By 2000 a distinct third domain had appeared. Ithad strong internal ... ranslational research ishappening, and why, so that they can formulate and testpolicy innovations that might foster it. Unfortunately,defining translational medicine and assessing its impacthas been...
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Báo cáo y học:

Báo cáo y học: "Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome" ppsx

... abnormalcentral pain mechanisms to clinical FM pain include temporalsummation of pain (or windup) and central sensitization.ReviewBiology and therapy of fibromyalgia: pain in fibromyalgiasyndromeRoland ... painsensitivity with spreading of hypersensitivity to uninjured sites and the generation of pain by low threshold mechano-receptors that are normally silent in pain processing. Thus,tissue injury might ... conducted by myelinated A-δ pain fibers,is often described as sharp or lancinating and can be readilydistinguished from second pain by most study subjects. In contrast, second pain (transmitted by unmyelinated...
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Báo cáo y học:

Báo cáo y học: " Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy" ppsx

... karyotypes by choosing only the firstwell-defined karyotype it contained. In case of multiplekaryotypes from the same patient (’case’ in the MitelmanDatabase), only one karyotype was taken into ... directly linked to the full description of the relevant karyotypes in the MitelmanDatabase. Repeating the analysis without filtering ambiguities and selected karyotypes (yielding 42,763 karyotypes, ... results of our analysis, including the computedassociations and links to their underlying karyotypes, arepublicly available for further investigation via our website[16]. Each karyotype is linked...
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