Báo cáo y học: "Tandem repeats modify the structure of human genes hosted in segmental duplications" docx

... manually analyzed all these 40 modifications in order to verify the effect of the repeats on the resulting pro-teins. In the majority of cases, the reading frame of the origi-nal protein is ... retention of repeats that can significantly diversify the sequence of the encoded proteins.Fifty percent of variable ITRs modify protein sequences In agreement with an active role in modifying proteinsequences, ... 2).Often these modifications occur in polymorphic human pro-teins, such as the keratin-associated proteins, the VCX /Y pro-teins, the nuclear pore interacting proteins, and the prostate-ovary-testis-endometrium...

Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"

... might in turn result in the uncertainty of the strategy for its treatment. While further delineati n g the clinicopathological and radiological features, and summarizing the surgical therapy strategy ... experience with the management of disseminated disease is very limited in the literature6, therefore, attention to the therapy strategy of this neoplasm in the future may allow a more reasonable ... 4-20). Nine patients had their tumors within the head, 2 in the body and 7 in the tail of the pancreas. Notably one patient was demonstrated to have liver metastasis. The predominant presenting...

Báo cáo y học: "Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study" pps

... priori hypothesis was that the birth order effectmay interact with the genetic predisposition of the off-spring in influencing future atopic manifestations. In order to test this hypothesis, ... Each of these SNPs had a minor allelefrequency ≥ 19%.Using the Haploview program [26], three of the fivesingle nucleotide polymorphisms (SNPs) of the interleu-kin 13 gene were in a linkage ... have it s ori-gin in utero [12], before an y hygiene effect in earlychildhood could affect the offspring. In addition, wefound that the number of live offspring significantlyreduces maternal...

Báo cáo y học: "Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states." ppt

... 4).Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampusFigure 3Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampus. Handling resulted in increased ... evidence indicates that among the serotonin recep-tors, the type 1A are involved in the etiopathogenesis of certain types of depression [23,24] and is the one throughwhich the therapeutic effects of ... with hypofunctioning of the sero-toninergic system. Recently BDNF has emerged as a majorfactor in the pathophysiology of depression: BDNF mRNAis increased in the rat brain following chronic anti-depres-sant...

Báo cáo y học: "Does listening to the sound of yourself chewing increase your enjoyment of food" ppt

... differentiation of emotions. Psychosomatic Medicine 1992, 54(4):422-435.7. Hetherington MM: The physiological-psychological dichotomy in the study of food intake. Proceedings of the Nutrition Society2002, ... effect of listen-ing to chewing sounds on the pleasure of eating. The pleasure of eating is influenced by many parameters. In addition to satiation of one's hunger and the taste of the meal, ... conditions in laboratory settings on the pleasure of eating may be greater than the effect of the experimental intervention. This is a limitation of thesetypes of studies.To our knowledge, this is the...

Báo cáo y học: "How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings" pdf

... participated in analysing the data andwriting the paper. AL participated in the genetic and statistical analysis. HSAparticipated in designing the study, analysing the data and writing the paper. ... participated in designing the study, analysing the data andwriting the paper. All authors read and approved the finalmanuscript.Competing interests The authors declare that they have no competing interests.Received: ... carrying the s allele),and according to t he recessive model (subjects carrying the l allele vs subjects not carrying the l allele). The first step included the calculation of the equiva-lent of...

Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx

... proteinase genes are regulated by TNF-induced MEK/ERK signallingWe further analysed the lists of genes that were induced byTNF using specific gene ontologies. Analysis of the list of TNF-induced, ... TNF-activatedNFB-DNA binding activity. The regulation of NFB-DNAbinding in primary cells can therefore be explained by the non-specific effect of DMSO on NFB activation. In the present study we determined ... cate-gorized by the molecular function of their protein products intocategories that included hyaluronic acid binding activity(including Agc1 and Hapln1) and proteinase activity (includingMmp-9...

Báo cáo y học: "Safety concerns on the development of novel therapeutic drugs" docx

... example of a system for monitoringchanges in gene expression that may be applied clinically. Bymeasuring the expression levels of 11 different genes associated with immune system pathways in peripheral ... approaches to analyzing the properties of asubstance at the cellular level and to deriving a more completepicture of the impact of a treatment on the human body.A prime example for bringing basic ... strategy for identifyingnonresponders as soon as possible – ideally even beforeinitiation of therapy – would be of great importance. In recent years gene expression profiling with microarraytechnology...

Báo cáo y học: " Exercise therapy for the management of osteoarthritis of the hip joint: a systematic review" pot

... review.Interventions The interventions included (a) hydrotherapy, which was prima-rily of low intensity and involved walking, leg swinging, andmobility exercises; (b) land-based swinging, mobility, andstretching ... painincluded the VAS; the pain subscale of the Harris Hip Score;and/or the pain subscale of the Health Related Quality of LifeTable 1Level of evidence for evaluating the efficacy of exercise therapy in ... A key point in the guidelines concerns the intensity of exercise required. In this regard, information provided by authors in the currentreview was very limited. Often, the prescriptions of sets...

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