... (eds): New Concepts in Diabetes and Its Treatment. Basel, Karger, 2000, pp 218–228 Erectile Dysfunction in Diabetes and Its Treatment M. Tagliabue, G.M. MolinattiDipartimento di Medicina Interna, ... per year, in which case insulin treatment must be initiated to maintain satisfactory gly-caemic control. In a substudy in the UKPDS, the effect of metformin versusconventional treatment and sulphonylureas ... or insulin in obese patients wasexamined. Patients randomized to metformin had lower risks for all-causemortality, strokes and any diabetes- related endpoint than patients on conven-tional treatment, ...