... repopulation was recently shown in the bone
marrow as well [6]. Of importance, the long-term reduction of
Editorial
Rituximab treatment in rheumatoid arthritis: how does it work?
Maria JH Boumans ... (like
antibody-dependent cellular cytotoxicity) are most important
in the elimination of circulating B cells as well as lymph node
and splenic follicular B cells [4].
Treatment...
... Arthritis with Concomitant Therapy Study Group: Infliximab
and methotrexate in the treatment of rheumatoid arthritis.
Anti-tumor necrosis factor trial in rheumatoid arthritis with
concomitant ... times during 78 weeks of infliximab therapy as determined by (a) Disease Activity Score (DAS 28) and (b) serum C-reactive protein levelsChanges in disease activity in 30 patients with...
... the cytokine network in such
induction has already been demonstrated for another
cytokine, interferon γ, inducing the development of autoan-
tibodies in patients with hepatitis C viral infection ... Access
Available online http://arthritis-research.com/content/6/6/R535
R535
Vol 6 No 6
Research article
Infliximab therapy in rheumatoid arthritis and ankylosing
spondylitis-induced speci...
... important in retaining
the cells at this site [17,18].
In about 20% of patients with RA, infiltrating T and B lym-
phocytes accumulate underneath the synovial lining layer
and organize into lymphocyte ... predominant infiltrate
the inflamed synovium, is consistent with their highly dif-
ferentiated state [11–16]. These inflammatory
chemokine receptors are prominently expressed on
effector...
... DRB1
In the initial, retrospective study, the frequency of B cells
was determined as a percentage of CD19
+
lymphocytes
from total T lymphocytes and B lymphocytes combined
(CD3
+
+ CD19
+
lymphocytes). ... homeostasis in RA reported here has not
been described previously. The clinical relevance of B
lymphocytopenia in SE-positive RA will be further investigated
in longitudinal studies...
... above). It is
tempting to speculate that chronic production of cytokines,
including TNF-α, may affect the myocardium in RA in either an
endocrine (originating in the synovium) or paracrine (produced
in ... with RA [106], the
complex relationship of RA-induced and RA therapy-induced
hyperhomocysteinemia to CHF risk in RA has yet to be
completely elucidated.
Inflammatory cytokines...
... 3
Probability plot: change/year in total radiographic scoreProbability plot: change/year in total radiographic score.
Figure 4
Probability plot: change/year in erosion scoreProbability plot: change/year ... A, et al.: Min-
imal clinically important difference in radiological progression
of joint damage over 1 year in rheumatoid arthritis: preliminary
results of a validation stud...
... modifications by showing that
treatment with the HDAC inhibitor trichostatin A induces
apoptosis in RASFs, while concomitantly FLIP (Flice inhibitory
protein) was found to be silenced [30]. Inherited retroviral
sequences ... primary transcripts within an alternative (mirtronic) pathway by splicing and debranching. Finally, from
the resulting miRNA duplex, the strand with the higher affini...
... fungus
growing in a cavity, in the lung or a sinus, often a maxillary
sinus. Aspergilloma has been found in 3.7% of patients under-
going surgery for chronic inflammatory sinusitis [12].
Sinus aspergilloma ... therapy Recovery [44]
Aspergilloma Lung Ankylosing
spondylitis
? Recovery [45]
Aspergilloma Lung Ankylosing
spondylitis
? ? [46]
Aspergilloma (× 2) Lung Ankylosing
spondylitis...
... analysis [37]. Ideally, future work could focus on
whether it is the impact of discrete pathology, such as IM or SM bursal hypertrophy, MTP joint
synovial hypertrophy or tenosynovitis that may ... rheumatoid arthritis. Rheumatol Int 2005, 26:42-47.
12. Rosenbaum D, Schmiegel A, Meermeier M, Gaubitz M: Plantar sensitivity, foot
loading and walking pain in rheumatoid arthritis. Rheu...