Báo cáo y học: "Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence" pdf
Báo cáo y học: "Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence" pdf
... drawn.ReviewValue of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence?Frank Moosig, Julia U Holle and Wolfgang L GrossDepartment of Rheumatology, University Hospital of ... campath-1H.Pneumocystis jiroveci The risk of PCP is especially high in patients with SVVundergoing induction therapy. Without using prophylaxis the incidence of PCP is up to 20% [26] and many fatalities ... [78].ConclusionInfections significantly contribute to morbidity and mortality in PSV patients. There are three ways of targeting this problem:recognising and minimising risk factors, implementingprophylaxis...
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Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
... alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistance in this ethnic group (3). But, that ... fixed in buffered formalin, embedded in paraffin, and stained with hematoxylin-eosin-safran and Masson's trichrome. Hepatic steatosis, stage of fibrosis and grade of disease activity were ... DNA, body mass index (BMI), homeostatic model assessment of insulin resistance (HOMA-IR) and pathological changes of the liver in inflammation, fibrosis and fatty deposition were examined in all...
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Báo cáo y học: "Management of HBV Infection in Liver Transplantation Patients"
... Lamivudine Monotherapy The goal of LAM monotherapy after OLT is to prevent reinfection of the allograft by inhibiting HBV replication in extrahepatic sites. Unfortunately, post-OLT monotherapy has ... and HBIG remain poorly defined. Postulated mechanisms include the synergy of: 1) LAM reducing HBV replication and altering synthesis of HBsAg necessary for generation of HBIG escape mutations ... preventing the receptor-mediated entry of HBV into hepatocytes and extrahepatic cells required for production of escape mutations in the YMDD motif. In addition to efficacy, combination therapy is...
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Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot
... acetylation eliminates theirbinding to decorin. Lys/Hyl side chains are thereforepresent at, or very near to the binding site(s) and theirpositive charge is a stringent requisite for the binding. ... interrupts the periodicity. On the other side, the relevance of Lys/Hylresidues both in collagens and peptides for interaction withdecorin is in contrast with the findings that the binding sitefor ... an thus hypothesize that the polyhistidine tag present in the recombinant decorinpreparation used by Keene et al. [19] is able, in the presence of minute amounts of proper cations, to interact...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... MU-meta-bolites in the inhibition of HA synthesis by MU in FM100cells. These above results indicate that something requiredfor a fully functional HA synthesis system is down-regulatedor inhibited in intact ... mechanisms for inhibition of HAsynthesis by MU. This information may be useful in the treatment of diseases involving excess production of HA.ACKNOWLEDGMENTSThis work was supported by Grants -in Aid ... in which the enzyme is intrinsically more active. For example, the HA translocation function, in which the growing HAchain traverses the bilayer in an intact membrane, may bemore efficient in...
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Báo cáo Y học: Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase A site-directed mutagenesis study docx
... measuredby the dye equilibration method of Minnaert [17], in orderto assess changes in the thermodynamic properties of the flavin centre caused by the mutation and to explain the different thermodynamic ... DAAO, the spectrum of the oxidized enzyme was converted into the reduced form, lacking the isosbestic points and peakmaxima characteristic of the formation of the semiquinoneintermediate. The ... to Y2 24 of the mammalian enzyme (the residueinteracting with the a-amino group of the substrate andwith a buried water molecule). Y2 24 in pkDAAO and Y2 38 in RgDAAO share the characteristics of...
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Báo cáo Y học: Role of histidine 42 in ascorbate peroxidase Kinetic analysis of the H42A and H42E variants pptx
... stability of Compound II. The replacement of the distal histidine residue by alanineor glutamic acid clearly has a profound in uence on the ability of the rAPX enzyme to react with H2O2and is clearly ... hydrogen-bonding interactions involving Arg38 in rAPX have beensimultaneously disrupted as a secondary consequence of the His42 mutations and, together with His42, may be in uen-tial in defining the ... that the initial product(Compound I) of the reaction of APX with H2O2 is aporphyrin p-cation intermediate and not a protein-basedtrytophan radical. Equally intriguing is the existence of...
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Báo cáo y học: "Role of Genetic Polymorphisms in Therapeutic Response to Anti-Asthma Therapy" pot
... geneticsto aid in choosing the most appropriate therapy. Asclinicians attempting to stay current in the evolving science of asthma, we must continue to follow the very excitingliterature regarding potential ... crucial to the bio-logic actions of corticosteroids.18This was accomplishedby retrospectively examining three independent clinicaltrials using ICS as the primary therapeutic intervention.Variation ... these therapeuticclasses; however, examination of all would be beyond the scope of this review. The most extensively studied GP in therapeutic asthmaresponse involves the b2agonist receptor. The...
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Báo cáo y học: "morbidity of overseas patients in inner London: A hospital based study" ppsx
... discussed. The involve-ment of consulates in the admission process of overseaspatients is suggested and the benefits of their involvementdiscussed.Setting The multidisciplinary MHT for this ... for ahearing may breach article 6. Discrimination in the provi-sion of services, such as individual therapies, multidisci-plinary team involvement, or treatment in locked unitsmay breach article ... positively with the high rate of involuntary admis-sions, and negatively with the type of offences attributedto these patients. A highly significant correlation wasobserved between length of admission...
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Báo cáo y học: "Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis" pps
... data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.References1. Fountoulakis KN, Grunze H, Panagiotidis P, Kaprinis G: Treatment of ... available clinical trialsconcerning the usefulness of aripiprazole in the treatment of the psychotic symptoms in bipolardisorder.Methods: A systematic MEDLINE and repository search concerning clinical ... phase.Discussion The meta-analysis of the four trials that investigated the efficacy of aripiprazole on psychotic symptoms (assessedby the PANSS) during acute manic/mixed episodes sug-gests that the...
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