Báo cáo y học: "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice" ppt
Báo cáo y học: "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice" ppt
... inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg miceMaung-Maung Thwin1, Eleni ... AA,Gopalakrishnakone P: Secretory phospholipase A2 activity in the normal and kainate injected rat brain, and inhibition by a peptide derived from python serum. Exp Brain Res 2003,150:427-433.9. Thwin MM, ... molecules and matrix degrading enzymes that are responsible for synovial proliferation and joint destruction [3], phospholipase A2(PLA2), a key enzyme in the production of diverse mediators of inflammatory...
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Báo cáo y học: "Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver" ppt
... partheno-lide's inhibitory effect on inflammatory mediators includ-ing activity and expression of cyclooxygenase (COX)[4,5], generation of prostaglandins [6,7], and leukotrienes(LT) [4] and expression of ... Inhibition of the expression of inducible cyclooxygenase and proinflam-matory cytokines by sesquiterpene lactones in macrophagescorrelates with the inhibition of MAP kinases. Biochem BiophysRes ... selectively modulated proin-flammatory cytokine gene expression in vivo. Only onegene, IL-6, was modestly suppressed which contrasts withmany in vitro studies suggesting anti-inflammatory effectsof...
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Báo cáo y học: " No effect of short-term amino acid supplementation on variables related to skeletal muscle damage in 100 km ultra-runners - a randomized controlled trial" potx
... dairy, including recordingtheir weekly training units in running, showing duration(minutes) and distance (kilometres), from inscription tothe study until the start of the race. In addition, ... recovery [40]. In runners,especially, the combined ingestion of carbohydrate and protein after each training session over 6 days reduced thepost exercise increase in serum creatine kinase and ... performances, and enhanced performance after combined ingestion of carbohydrates and p rotein. It has been demonstratedthat consumption of a carbohydrate-protein beverageduring an intense cycling performance...
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Báo cáo y học: "The effect of continuous positive airway pressure (CPAP) on renal vascular resistance: the influence of renal denervation" doc
... prednisolone, azothioprine and cyclosporin.Seven of the patients were on antihypertensive medica-tion, consisting of a beta-blocker in five cases and nitrates in two. None of them had a history of ... by anaesthetic agents and by the continuous infusion of dopamine given duringthe transplant surgery [30]. Thirdly, ischaemic reperfusioninjury may have affected the response to PEEP. Finally, and ... Hormonal interactions and renal function during mechanical ventilation and ANF infusion in humans. J Appl Physiol 1991, 70:287–292.21. Hall SV, Johnson EE, Hedley-Whyte J: Renal hemodynamics and function...
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Báo cáo y học: "The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation" ppsx
... possibly because none of these samples inducedany significant increase in neutrophil influx compared tothe control. In addition to inducing inflammation, as indicated by cel-lular changes with in ... most pro-inflammatory metal in their study followed by manganese and nickel, while vanadium, iron and zinc induced simi-lar levels of inflammation. This study analysed the metalcontent of Redcar ... valley PM10 in relation to its toxicity and pro-inflammatory potential, bycarrying out a range of human [4], animal [5] and in vitrostudies [6,7]. Further analysis of Utah PM10 metal contentshowed...
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Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot
... function.LysoPC inhibition of group IA sPLA2 activityFigure 3LysoPC inhibition of group IA sPLA2 activity. (A.) Relationship between substrate concentration and velocity in reac-tions of group ... albumin binding does not effect the binding to PC con-taining particles and subsequently the ability of the lys-oPC to inhibit enzyme activity, or that 2), in somesituations the affinity of ... and LCAT activity in nephrotic and analbuminemic rats. KidneyInt 1994, 46:97-104.58. Kim YL, Im YJ, Ha NC, Im DS: Albumin inhibits cytotoxic activity of lysophosphatidylcholine by direct binding....
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Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... reducing LV dyssynchrony and thereby liber-ating a further segment of the RR interval for diastole (24). Considering that direct evaluation of LV dyssynchrony is still complex and time-consuming, ... test, interventricular dyssynchrony Introduction The introduction of cardiac resynchronization therapy has recently renewed the clinical interest in the analysis of specific phases of the ... condi-tions resulting in a prolongation of left ventricular ejection and total LV systole (10,11). This effect of loading conditions on the duration of LV systole is a well documented finding...
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Báo cáo Y học: The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme pdf
... enzymatic reaction steps of aldosteronesynthesis from DOC, s uggesting only minor functionalrelevance of lysine 152 in human C YP11B2. In contrast to the insertion of glutamic acid in position147, ... CYP11B2reaction steps. The combination of functional data and computer modelling of CYP11B2 suggests an indirectinvolvement of r esidue 147 in the regulation of CYP11Bisoform specific substrate conversion ... mainly located in the C-terminal regions of CYP11B1 and CYP11B2. So far, the role of distinct amino acids of theN-terminal regions of human C YP11B isozymes h as n otbeen studied extensively,...
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Báo cáo y học: "Class effect of pharmacotherapy in bipolar disorder: fact or misbelief" pptx
... Swindle R, Yu X, Risser R, Baker RW, Tohen M: Effects of olanzapine alone and olanzapine/fluoxetine combination on health-related quality of life in patients with bipolar depression: secondaryanalyses ... data are only posi-tive concerning valproate, carbamazepine and lamotri-gine, and only against specific phases of the illness.From a clinical point of view, depression and themaintenance ... K, Minkwitz M, Macfadden W: A randomized,double-blind, placebo-controlled study of quetiapine in the treatment of bipolar I and II depression: improvements in quality of life. Int ClinPsychopharmacol...
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