Báo cáo y học: "Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort" pdf
... Markers of B-cell activation are elevated in
patients with early RA, compared with undifferentiated arthritis,
independently of any systemic increase in BAFF secretion, and
correlate with disease activity. ... B-cell activation [32]. Investigation of the
role of APRIL in the B-cell activation of patients with early RA
therefore appears usef...
... that combinations of polymorphic genes may act in
concert in the pathogenesis of SLE, a concept that may be
instrumental in the analysis of the genetics of SLE as well
as providing hypotheses for ... common. Ninety percent of the SLE
patients with HLA DR3 displayed the haplotype DR3-DQ2-
C4AQ0, compared with 86% of the controls. The frequen-
cies of th...
... findings as preliminary and requiring
replication in other settings. Additionally, data from the VA
might be gathered differently from other health care systems,
again highlighting the preliminary ... antibody therapy in rheumatoid arthritis and
Figure 1
This plot illustrates the median and interquartile range for the tertiles of the claims-based index of rheumato...
... Duration of VIT < 5 years
• Repeated re-stings after stopping VIT
Patients with reactions during immunotherapy are
encouraged to receive immunotherapy indefinitely.
In our survey 229 patients ... studies are needed to evaluate the accuracy of the
test.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
MK has bee...
... combined
antiretroviral therapy (cART) with or without ABC were
compared in order to pinpoint a pathogenic mechanism
for the increased risk of myocardial infarction in patients
using ABC. Given the important role of ... increased incidence of myocardial infarction. The
pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in...
... present in inclusion body. In order to recover its
function, the fusion protein in inclusion body was
refolded in urea gradient refolding buffer. And then,
the refolded protein was incubated with ... used a
glycine-rich short peptide including 15 amino acids to
connect the N-terminus of globular adiponectin and
the C-terminus of GLP-1-A. Compared with native
G...
... fat as the tumour
invades it. Thus, carcinoma is typically characterized by
the lack of isolated pockets of fat within its mass and this
is demonstrated in these results by the lack of any adipose ... fibroglandular
and fibrocystic changes peaks are close, they are
statistically separated.
Using the results in Table 2 effective d-spacings have
been found. These...
... HCD
apparently potentiated the cytokine-inducing effects of
LPS without qualitatively altering their sequence of
appearance. Others found that hypercholesterolemia
increased the induction of plasma ... 9).
VCAM-1 and iNOS were measured since they are part of
an inflammatory cascade induced by LPS. VCAM-1 medi-
ates localization of various inflammatory cells in tissues.
iNO...
... gelatin substrate
at sites of net gelatinase activity yields fluorescent gelatin-
FITC peptides and the intensity is proportional to the
amount of activity within in the tissue.
Corneal epithelial ... and the intensity of the stain-
ing was analyzed in digital images (Figure 2A). Using dual
label laser scanning immunofluorescent microscopy,
both IL-2R chains were p...
... on the secondary structures indicate the length of the single stranded regions. Black rectangles locate Hfq binding sites determined by
enzymatic and chemical probing and by mutational analysis. ... hierarchy of Hfq
binding efficiency to these different RNAs harboring
internal or 3¢ terminal presumptive binding sites.
Interestingly, Fig. 3 shows that Hfq exhibits roughly
the sa...