Báo cáo y học: "Developments in the clinical understanding of lupus" pot
Báo cáo y học: "Developments in the clinical understanding of lupus" pot
... bytype I IFN.A randomized placebo-controlled study of the withdrawal of hydroxychloroquine treatment in clinically stable SLE patientswas published in 1991 by the Canadian HydroxychloroquineStudy ... JL,Cividino A, Danoff D, Osterland CK, Yeadon C, Smith CD: Along-term study of hydroxychloroquine withdrawal on exacer-bations in systemic lupus erythematosus. The CanadianHydroxychloroquine Study ... pathophysiology through theircapacity to focus relevant antigens for presentation to T cells,by production of cytokines, through their role in organizing the anatomy of the germinal centers and other...
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Báo cáo y học: " Developments in the scientific understanding of lupus" pot
... responses. Furthermore, immune complexes of ANAscan drive the production of proinflammatory cytokines, inducing the ‘interferon signature’, and intensifying disease. Together, thesefindings point to ... entirety of the immune system. Some of these maybe genetically determined, whereas others arise secondarily in response to events such as infection. Not surprisingly,delineation of these disturbances ... pathways suchas transfection or DNA-binding proteins [11,12]. Within the context of SLE, these findings suggest that moleculesinducing autoimmunity have intrinsic immunologic activity andmay serve...
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Báo cáo y học: "Developments in the clinical understanding of osteoarthritis" docx
... the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which the lead investigator became the study subject ... providednew insights into how OA may be successfully managed. The symptoms of osteoarthritis: pain andinstability The pain of OA is activity-related, with pain coming ongenerally only when a person ... not the only symptom of OA experienced by patientswith knee and hip OA. They also frequently experience asensation of instability or buckling. The most commonsymptom is one of shifting or instability...
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Báo cáo y học: "Developments in the clinical understanding of rheumatoid arthritis" ppt
... consequence of the activation of many cell populationsand, ultimately, of the upregulation of proinflammatory cyto-kines [19,20]. By whichever means they themselves becomeactivated, they induce ... 1Composite indices are the best depicters of disease activity. The degree of disease activityat the start of a disease-modifying therapy is amajor determinant of the disease activityattainable in ... regardless of their level of improvement.These and other insights mandate a change in clinical trialreporting by requesting the provision of information on cate-gories of disease activity attained in...
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Báo cáo y học: "Developments in the scientific understanding of osteoarthritis" doc
... orinhibitors of inflammatory cytokines.Degeneration of articular cartilage in osteoarthritis:inflammation The role played by inflammatory cytokines and mediatorsproduced by joint tissues in ... hypertrophy and hyperplasia, withan increased number of lining cells, often accompanied byinfiltration of the sublining tissue with scattered foci of lymphocytes [68]. Synovitis is often localized ... latent enzymes isregulated by at least two enzyme inhibitors: tissue inhibitor of metalloproteinases and plasminogen activator inhibitor-1[45]. These enzyme inhibitors are synthesized in increasedamounts...
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Báo cáo y học: "Developments in the scientific understanding of osteoporosis" docx
... localregulation has increased over the past 10 years through the discovery of the canonical Wnt signaling pathway. The Wntfamily of glycoproteins represents a major signaling pathwaythat is involved in cellular ... as an inflammatory arthritis in which jointinflammation results in bone deterioration. In RA, the pro-inflammatory cytokine TNF-α is critical in driving inflammatorydisease. TNF is mainly produced ... serotonin synthesis in enterochromaffincells in the duodenum. Serotonin appears to inhibit osteo-blast proliferation by binding to its receptor, 5-hydroxy-tryptamine receptor 1B, on the osteoblast...
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Báo cáo y học: "Developments in the scientific understanding of rheumatoid arthritis" pot
... knowledge of the pivotal role played by cytokines during the effector stages of human disease; has been instrumental in clarifying the place of cytokines in the maintenance and chronicity of inflamma-tion; ... onidentifying mechanisms upstream of the synovial inflamma-tion. The most promising finding paving the way for potentialpreventive therapy relates to the more recent concept of asystemic prodromal ... citrullination may play a role in the initiation of an immune response. The finding that Asian RApatients are more likely to have inherited an enzyme variant of PADI-4 (peptidylarginine deiminase...
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Báo cáo y học: " Developments in the synovial biology field 2006" potx
... fromleukocytes can play a role in inflammatory arthritis by inducing the synthesis of MMPs, chemokines and cytokines in SF[11,12]. It could also be shown that, in particular, the synthesis of MMP-1, ... [40].OsteoclastogenesisMacrophages/monocytes are not only involved in inflam-matory reactions, but also in the remodeling processes of the bone. Two studies published in the past year provided newinsights in the role of monocytes ... due to the proliferation of genuine synovial cells such as SF [2] and a massiveinfiltration of inflammatory cells [3]. As a consequence, the inner layer of the synovium, the lining layer, increases...
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Báo cáo y học: "Developments in the scientific and clinical understanding of the spondyloarthritides" pptx
... respectively) of clinical symptoms. Andrei Calin, of Bath, UK, had started thiskind of work in the early 90s with the definition of the BathAnkylosing Spondylitis Disease Activity Index (BASDAI) ... over the last 10 years both in the clinical and scientific understanding of the spondyloarthritides(SpA), which can be separated in predominantly axial andpredominantly peripheral SpA. The clinical ... for one of the defineddiseases [2]. The leading clinical symptoms for all subsets of SpA are inflammatory back pain and/or an asymmetricalarthritis predominantly of the lower limbs. These criteriaalready...
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Báo cáo y học: "Developments in the scientific and clinical understanding of autoinflammatory disorders" doc
... as a pyrin domain (PYD) in other proteins that have homology with pyrin’s N-terminalsequence [12]. Members of the death domain superfamily areinvolved in the assembly and activation of apoptotic ... characterised by fluctuating orirregularly recurring episodes of fever and systemic inflam-mation, affecting the skin, eyes, joints, and serosal surfaces.They include the hereditary syndromes familial ... pathogenesis of manyautoinflammatory diseases has led to major advances in theirtreatment, most remarkably the introduction of IL-1 inhibition in CAPS. The clinical significance of low-penetrance...
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