... unit increase in body mass index; physical activity = percentage change per unit increase in physical activity level; grade of
osteophytes = percentage change per increase 1 in grade of osteophytes; ... associated with an increased
grade of joint-space narrowing, not of osteophytes. In this
study, we measured only bone size and not bone mineral den-
sity, which may be importa...
... cells to
undergo a Th1 to T-helper type 2 shift and increase the
secretion of anti-inflammatory cytokines IL-10 and IL-4, while
decreasing the secretion of proinflammatory cytokines TNFα
and IL-1 ... most of the available information regarding the
temporal cytokine profiles in arthritic LEW rats pertained to
antigen nonspecific ex vivo cytokine secretion or to cytokine
mRNA le...
... phenylglycyl- and p-hydroxyphe-
nylglycyl-enzyme of bF24A, as indicated by, respectively, a
twofold and fourfold increased V
s
/V
h
ratiocomparedtothe
wild-type (Table 4). The V
s
/V
h
ratio using ... property of bF24A is its increased esterase/
amidase ratio. In general the enzyme-catalysed hydrolysis of
esters is faster than the hydrolysis of the corresponding
amides due to the...
... role of
CD4
+
CD28
–
T cells in RA pathogenesis may be related to
their cytotoxic capability, which may contribute to extra-
articular manifestations. The higher frequency of these
cells in patients ... contribution to the pathogenesis of
rheumatoid arthritis. Curr Opin Rheumatol 1998, 10:187-200.
2. Janeway CA Jr, Bottomly K: Signals and signs for lymphocyte
responses. Cell...
... immunotherapy of
inflammatory autoimmune diseases [26,27].
Role of IL-17 in the pathogenesis of RA
RA is a chronic systemic disorder that is characterized by
autoimmunity, infiltration of joint synovium ... complexes in the cartilage surface layer
during CIA probably releases oxygen species and
proteolytic enzymes present in PMNs directly into the
surface of cartilage, thereby...
... means to
interfere with the inflammatory response in SLE by adminis-
tering only an induction regime of four infusions of infliximab
within 10 weeks rather than by planning for long-term therapy.
Evidence ... variety of murine models. They differ in
parts of their phenotype and especially in the underlying
genetic factors, which lead to their disease. With respect to
TNF,...
... relation to any single item in a
sentence, are set off by a minor phrase boundary.
whereas final constituents that modify a particular
item are less perceptibly set off. This is the
distinction ... uniformly set off by a high boundary value
and should remain so. In contrast, the boundary value
of final prepositional phrases, particularly those with
a monosyllabic preposition
(...
... & Roy, A.D. (1969) Fate of
trypsin and chymotrypsin in the human small intestine. Gut 10,
477–483.
3. Low, A.G. (1982) The activity of pepsin, chymotrypsin and trypsin
during 24 h periods in the ... 2).
Finally it is of interest regarding the in vivo mechanism of
inactivation, that chymotrypsin and trypsin, mixed in
concentration ratios close to those in the intestines...
... outside hospitals in Norway. Emergency
medicine is not a formal speciality for doctors in Norway.
Still, treatment of critically ill or injured people is defined
as emergency medicine. Earlier white ... (34)
Other musculoskeletal symptoms L29 (396)
Other 465 10 2.3 10 400
Endocrine/metabolic symptoms T29 (11)
Urinary/male genital symptoms U29 (7) Y2 9 (5)
Pregnancy/female genital sympt...
... median
number of days of hyponatraemia (IQR = one to three days)
and hypernatraemia (IQR = one to five days) was two.
Multivariable analysis of patient characteristics
The incidence of ICU-acquired hyponatraemia ... could
potentially be used to help clinicians identify patients at
increased risk. An elevated baseline creatinine was associated
with a 50% increased risk of ICU-a...