Báo cáo y học: " Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis" pps

... by the cross-sectional nature of the analysis, and the discrepancymay be the result of random variability. Importantly, a singlemeasurement of inflammatory cytokines is not representative of ... 2Research article Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of AtherosclerosisJon T Giles1,6, Moyses Szklo2, Wendy Post1,2, Michelle ... Prevalence ratios indicate the ratio of the prevalence of coronary artery calcification > 0 for RA participants compared with Multi-Ethnic Study of Atherosclerosis controls. Analyses include 1,222...

Báo cáo y học: "Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab" ppt

... antibody synthesis to the pathogenesis of RA, their applicability in interventional biopsy-based clinical tri-als is limited. Synovial tissues obtained by arthroscopy or nee-dle biopsy typically ... immunoglobulin ana-lyte, synovial/serum index (SSI) was defined as the ratio of synovial analyte/synovial albumin divided by the ratio of serumanalyte/serum albumin.Open AccessAvailable online http://arthritis-research.com/content/10/5/R105Page ... 28:197-203.15. Youinou PY, Morrow JW, Lettin AW, Lydyard PM, Roitt IM: Specif-icity of plasma cells in the rheumatoid synovium. I. Immu-noglobulin class of antiglobulin-producing cells. Scand...

Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc

... α.IL-1Ra increased significantly during the first year in both study groups, but the rise was not sustained until the end of the trial. One hypothesis to explain this finding is that vitaminD3, ... significantly in the HRTgroup. Furthermore, the change in E2 in serum wasinversely, though modestly, correlated with the change in sIL-6R. The change of sIL-6R was inversely associated with increase ... baseline, which haspreviously been observed [35], and, interestingly, the change of ESR during the course of the study was highlycorrelated with the change of IL-6 and to a lesser degreewas inversely...

Báo cáo y học: "Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia" pptx

... A: Induction by inter-leukin-7 of lymphokine-activated killer activity in lymphocytesfrom autologous and syngeneic marrow transplant recipientsbefore and after systemic interleukin-2 therapy. ... could therefore result in aburst of thymic activity. In contrast, it is not immediatelyobvious what other factor(s) could determine the delayedrise in thymic activity in RA patients. Other ... grown, in accord-ance with standard techniques [34,35]. By allowing the for-mation of an adherent layer consisting mainly of macrophages and cells of mesenchymal origin, this culturesystem...

Báo cáo y học: "Interleukin-7 deficiency in rheumatoid arthritis" ppsx

... basis for the prolonged lymphopenia of CD4+T cells after lymphocyte-depleting therapyspecifically of patients with RA in comparison with otherdisorders, and report that interleukin-7 (IL-7) ... fibroblast-likesynoviocytes are also relevant in RA pathogenesis andrepresented in synovium/pannus [5]. The accessibility of synovial fluid has permitted the documentation of elevatedlevels of cytokines, including ... including pro-inflammatory cytokinessuch as IL-1, TNF-α, and IL-6 and a large range of others[5]. The evidence in support of an immune basis has led tolympho-depleting therapies, including,...

Báo cáo y học: "egulatory T cells in rheumatoid arthritis" ppsx

... http://arthritis-research.com/contents/7/3/9398prevent inflammatory activity in the joint, the CD4+CD25+Tregs in the inflamed rheumatoid synovium mightnevertheless be important for a downmodulation of the inflammation, thereby delaying further ... selectively recruited to and retained in the rheumatoid joint through interactions involving CXCR4. In line with the hypothesis that CD4+CD25+T cells areeffectively recruited to sites of chronic inflammation,CD25+CD4+T ... oranti-TNF therapy and the frequency of CD4+CD25+T cells in the synovial fluid [31]. These data suggest that the presence of CD4+CD25+T cells in the rheumatoid synovium is afunction of the...

Báo cáo y học: "Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis" pot

... not of collagen synthesis, are related to jointdestruction in RA. The use of these biomarkers may be of valuewhen studying progression of joint damage in patients with RA.Introduction Rheumatoid ... may predict the progression of jointdamage. Radiographs only record the outcome, namely jointdamage. Hence measurement of a product of the processresulting in joint damage may be of value in ... defined as the difference between the log-transformed radiological scores at year (i + 1) versus the scores year (i) using the differences of year 2 minus year 1, of year 3 minus year 2, and of...

Báo cáo y học: "proximal interphalangeal joints in rheumatoid arthritis: a comparison with magnetic resonance imaging, conventional radiography and clinical examination" pdf

... Ultrasono-graphic and clinical findings agreed on the presence of signs of inflammation in 103 joints (21% of the 480 joints) and on the absence of signs of inflammation in 268 joints (56%). In 91joints (19%), ... effusion in any of the examinedfinger joints, whereas ultrasonography revealed joint effusion in 22 out of the 433 examined finger joints.Signs of inflammation on ultrasonography (joint effusion ... ultrasonog-raphy was more sensitive than clinical examination in assess-ing signs of inflammation, with only a slight loss of specificity. The present study strongly encourages further studies of useof...

Báo cáo y học: "TH-17 cells in rheumatoid arthritis" pdf

... RA.IntroductionInterleukin (IL)-17 may play a critical role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is capable of promotinginflammation by inducing a variety of pro-inflammatory media-tors, ... found at very low levels in the RA joint [5], the source of IL-17 in the RA joint was unclear until the recent discovery of a third subset of T cells capable of producing IL-17, the TH-17 cells. ... may modulate the development of TH-17 cells in the RA joint.Conclusion In summary, these observations support the role of TH-17 cells in the pathogenesis of RA. However, the role for IL-23 in established...

Báo cáo y học: "Peripheral arterial disease in polymyalgia rheumatica" ppt

... vasculitis can therefore occur and maycontribute to the increased risk of PAD in isolated PMR.Conclusions The interesting findings of Warrington and colleagues addfurther weight to the association ... cardio-vascular disease in systemic lupus erythematosus or rheuma-toid arthritis on postmortem examination [3]. Arteritis remainsa possibility, however, in PMR and GCA. A study of biopsy-proven GCA ... increase in carotid intimalthickness, so atherosclerosis alone does not explain the increased cardiovascular mortality seen in GCA [9].Although Warrington and colleagues did not find that the presence...

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