... sus-ceptibility, given the role played by CTLA-4 (cytotoxic T-lym-phocyte associated 4) in T-cell activation and that a CTLA- 4- IgG1 fusion protein is very effective in treating RA [62]. The Table ... D, Gya-pay G, et al.: New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl AcadSci USA 1998, 95:1074 6-5 0.3. Jawaheer D, Gregersen PK: Rheumatoid ... of RA [64], because the dates of diagnosis for most of the RA cases in this cohortpreceded the clinical use of anti-CCP. Further analysis by anti-CCP status could be potentially informative.Although...