... article
The relationship between inflammation and new bone formation
in patients with ankylosing spondylitis
Xenofon Baraliakos
1
, Joachim Listing
2
, Martin Rudwaleit
3
, Joachim Sieper
3
and Juergen ... nature and the length of the time interval between inflam-
mation and new bone formation are unclear. Animal models
imply that new bone formation...
... PTPN22,
STAT4). Finally, the clinical relevance of these data regarding
RA and malignancy is unclear. Should clinicians screen RA
patients differently than typical patients?
Competing interests
The ... understanding of malignancy in RA
forward but raises many important questions for future
research. First, as much of the literature they cite (and most of
the patients included in...
... outcomes, without artificially compelling a linear
relationship between MPR and outcomes, or arbitrarily
determining that any particular MPR threshold is appro-
priate. All analyses were conducted using ... even if
they were fully compliant with their prescribed therapy.
Finally, this study focused on both atypical and conven-
tional antipsychotics, without controlling for class or...
... proline is
inhibitory at P4 and P9. These constraints allow for few
glycine–proline combinations that will permit interaction
between peptide and the DR4 binding groove.
The immunogenicity of ... (remov-
ing a single methylene group) within a hemoglobin peptide
bound by I-E
k
induced a significant variance in the peptide
main chain between P5 and P8, and changed the rotamer
conf...
... critical information
regarding clinical factors associated with pain severity, they
did not quantify the patients& apos; underlying pain sensitivity or yield
information about pain mechanisms.
Pain ... anti-inflammatory
therapy, rheumatoid arthritis (RA) patients continue to rate pain
as a priority. The etiology of RA pain is likely multifactorial,
including both inflammatory and non-i...
... periods in a sleep diary and collected urine samples during each day's main sleep
period. The samples were subsequently assayed for the metabolite of melatonin in urine, 6-
sulphatoxymelatonin ... studies linking melatonin production and
sleep propensity [12-18], and evidence demonstrating the
relationship between sleep consolidation and melatonin
production in a forced...
... autonomic nervous system, including the
brain stem, spinal cord, hypothalamus and cerebral
cortex. Demyelinating plaques may disrupt reflex
pathways in the insular, cingulated and ventromedial ... inflammatory de-
myelinating disease of the central nervous system
(CNS) that is a leading cause of disability in young
adults.
Autonomic dysfunction is commonly seen in
patients...
... lymphocytes. Involvement of
VLA-4 and inhibition by interferonbeta-1b. J Clin Invest 1997,
100:604-612.
5. Coclet-Ninin J, Dayer JM, Burger D: Interferon-beta not only
inhibits interleukin-1beta and ... number of patients for this study,
we did obtain important safety and efficacy information.
The primary outcome of the study was safety. IFN-β-1a
was generally well tolerated by these...
... Activity Score and the
DAS28. In a study performed in Italy in the late 1990s, it was
found that the Disease Activity Score was the best measure
to discriminate between predefined states of low and ... advantage
to use a continuous measure with absolute values to measure
disease activity in daily clinical practice and clinical trials.
Conclusion
The study of Vander Cruyssen...