Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis" doc
Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis" doc
... citation purposes)Vol 10 No 3Research articleThe human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with ... activity. Proof-of-concept clinical trial in patients with RA A proof-of-concept study to explore safety and tolerability,pharmacokinetics and pharmacodynamics was conducted in patients with established ... ther-apy in RA patientsReduction in disease activity and CRP levels following ACZ885 ther-apy in RA patients. (a) Mean disease activity (Disease Activity Score using 28 joint counts [DAS28]) levels...
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Báo cáo Y học: The human b-globin locus control region A center of attraction potx
... fractionation by mercury a nity chromatography: contrasting distribution of transcrip-tionally active and acetylated histones in nucleosome fractionsof wild-type yeast cells and cells expressing a ... D., Francastel, C., Cimora, D.M., Reik, A. , Martin,D.I.K. & Groudine, M. (2000) Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation ... om-plexes involved in chromatin r emodeling and histoneacetylation.REPLICATION AND CHROMATINSTRUCTUREThe human b-globin l ocus replicates early in erythroid cells and l ate in nonerythroid...
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Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... IIA sPLA2s. Ammody-toxins (Atxs) are presynaptic sPLA2neurotoxins, ammo-dytins (Atns) I1 and I2are nontoxic sPLA2s, and AtnL is a myotoxic but enzymatically inactive sPLA2homolog[11–15]. ... binding protein for Atxs was isolated and identified as calmodulin (CaM) [19], indicating that thishighly conserved, Ca2+-sensing regulatory molecule [20]mayplayaroleinthesPLA2-neurotoxicity. In ... Pungercˇar21Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana,Ljubljana, Slovenia;2Department of Biochemistry and Molecular Biology...
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Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
... ADAMTS5 are protected to a great extent from OA in joint instability models, indicating that this enzyme may play a major role in cartilage catabolism, at least in mouse models ofOA [48-50]. Interestingly, ... 2% isoflurane and 0.8 L/minute oxygen. The surgical area was shaved and a three-part preparation was applied containing hibitane soap(Ayerst, Montreal, Quebec, Canada), isopropyl alcohol and betadine ... significantly increased in early OA, indicatingthat the retinoic acid pathway may play a role in OA patho-physiology.Materials and methodsSurgerySurgeries were performed on 10-week-old male...
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Báo cáo y học: "The need for intra aortic balloon pump support following open heart surgery: risk analysis and outcome" pdf
... sec. Routine administra tion of a Cefalos-porin 2ndgeneration in combination with vancomycin,through out the IABP support, was maintained.Statistical analysisCollection o f the data is served ... served using the Patients Ana-lysis and Tracking System (PATS) software. Eighty vari-ables were prospectively collected and carefully validatedbefore being analysed.Categorical variables were ... for intraoperati ve IABPinsertion.Ninety patients had intraaortic balloon inserted intrao-peratively with a mortality of 33.3%. We attempt to splitthe intraoperative IABP insertion patient...
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Báo cáo y học: "The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin" ppsx
... 100 and 100 g. This is supported bythe fact that heavy chain combinations containing arginineto serine mutations at these positions (IS4 VHiii and IS4 VHiv) displayed approximately 50% weaker ... thegeneral population [4] and a major cause of pregnancymorbidity.APS may occur as a 'freestanding' syndrome (primary APS)[5] or in association with other autoimmune rheumatic dis-eases ... [17,18].Sequence analysis of human monoclonal aPL has shownthat IgG aPL, but not IgM aPL, often contain large numbersof somatic mutations in their variable heavy chain region(VH) and variable light chain...
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Báo cáo Y học: The a1b1 contact of human hemoglobin plays a key role in stabilizing the bound dioxygen Further evidence from the iron valency hybrids potx
... stereochemistry ofthe iron-dioxygen bond in human HbO2by single-crystalX-ray analysis. In the a chain, the distance between NeofHis (E7) and the terminal oxygen atom (O-2) is found to be2.7 A Ê, ... chains in acidic pH range. More speci®cally, the b chain h asacquired this stability by blocking out the proton catalysisperformed by the distal histidine residue (Eqn 4).Similarly, Shaanan ... has b een clearly shown that the rate is greatlyaccelerated with the proton assistance by a factor of morethan 106mol)1, as formulated by Eqn (4). In this protoncatalysis, the distal histidine,...
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Báo cáo y học: "The proliferative human monocyte subpopulation contains osteoclast precursors" ppt
... proliferation and differentiation ofosteoclast progenitors. J Clin Invest 1993, 91:257-263.6. Matsuzaki K, Udagawa N, Takahashi N, Yamaguchi K, Yasuda H,Shima N, Morinaga T, Toyama Y, Yabe Y, Higashio ... Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989, 74:2527-2534.11. Kawanaka N, Yamamura M, Aita T, Morita Y, Okamoto A, Kawashima M, Iwahashi ... the data, and drafted the manuscript. PDK performed the statistical analysis.JAH supervised the study and finalized the manuscript. Allauthors read and approved the final manuscript.AcknowledgementsThis...
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Báo cáo y học: "The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes" ppt
... Introduction In diarthodial joints, cartilage provides a smooth surface thatenables joints to articulate and to withstand compressional and shear stress [1]. Embedded in the cartilage are ... chondro-cytes that respond to biochemical and physical stimuli tomaintain this tissue. Cartilage is primarily composed of type IIcollagen and proteoglycan, which are synthesized by thechondrocytes. ... cytokines are present, resulting in an inflammatorystate as well as cartilage degradation [14]. As further evi-dence for the role of pro-inflammatory cytokines in RA,anti-tumor necrosis factor-α (anti-TNF-α)...
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Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx
... signalling [13–15].RA is characterized by synoviocyte proliferation and infiltration of inflammatory cells, such as lymphocytes and macrophages, into the joint. Local release of pro-inflammatory ... fibroblasts and articular chondrocytes. (a) Human osteoarthritis (OA) synovial fibroblasts (passage 1), (b) de-differentiated human OA articular chondrocytes (passage 2), and (c) freshly isolated human ... by leflunomide in RA and other cartilage-damagingdiseases.Competing interestsThis work was supported in part by an unrestrictedresearch fund from Aventis Pharma (Frankfurt am Main,Germany).AcknowledgementsThis...
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Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnbáo cáo khoa học y họcbáo cáo y tế học đườngmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ