Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx
Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx
... in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysisDongquan Shi1,2, Takahiro Nakamura3, Masahiro Nakajima4, ... oste-oarthritis. Nat Genet 2007, 39:529-533.6. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K,Notoya K, Nakamura Y, Ikegawa ... SNPs and knee OA susceptibility, we conducted two case-control studies in Han Chinese and Japanese popula-tions and a meta-analysis.Materials and methods A population of 955 Chinese individuals...
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Báo cáo y học: "Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as control" doc
... genetic association in a RA-OA case-control set-ting in a Slovak population.Materials and methodsStudy participants A total of 520 Slovak individuals (87 males, 433 females) with the diagnosis of ... analysis and drafted the manuscript. JR and SB collected the sample and phenotyped the patients. HGW and SF carried out the HLAtyping. CH participated in study coordination and helped todraft ... Hardy-Weinberg equilibrium [see TablesS11 and S12 in Additional data file 1].Additionally, we carried out a subset analysis of RA samplesstratified to RF status. Association between RA and HLA-DRB1...
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Báo cáo y học: "Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population" doc
... Russian Federation. Theextent of osteoarthritis was determined by analyzing plain handradiographs. The outcome of a principal component analysis of osteoarthritis scores of a total of 28 joints ... joints of each hand separately, in accordance with thegrading system of Kellgren and Lawrence [19]. The OA evalu-ation was based on radiographic changes, such as presence of osteophytes, joint-space ... of calcium-containing crystals in articular cartilageobserved in these families is a common finding that is fre-quently associated with advanced OA. In contrast to general-ized arterial calcification...
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Báo cáo y học: "Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region" pot
... Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yas-utomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H,Kamatani N, Momohara S: Association of STAT4 with ... USA), and association was examined in 308SLE patients and 306 healthy individuals.Statistical analysisAssociation of each SNP was analyzed by chi-square test.Because of the replicative nature ... MK, and TA participated in the first screening using Illumina Gold-enGate assay (with AK), including tag SNP selection, geno-typing, and statistical analysis. JO carried out statisticalanalysis...
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Báo cáo y học: "Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan" pptx
... ndividual is willing to participate and is capable of giving informed consent; and (3) individual is a self-reported non-aboriginal Taiwanese, and none of the par-ents and grandparents has aboriginal ... leukocytesusing a genomic DNA kit (Qiagen) a ccording to themanufacturer’s instructions. Genotyping was achievedusing an assay-on-demand allelic discrimination assay and detection system according ... during disease progression after therapy.AcknowledgementsWe thank Hsuan-Min Chuang, Chu-Cheng Tsai and Su-Ching Liu for thetechnical assistance in preparation the DNA and analyzing the polymorphisms. ...
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Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"
... records and/ or self-reported questionnaire and each case was validated by cardiac ultrasound and/ or electrocardiographic examinations or by coronary angiography. Table 1: Patient characteristics. ... precipitation of apoB containing lipoproteins with phosphotungstate (Boehringer Mannheim). Apoliprotein AI (Apo AI) and Apo B were measured using the Beckmann Array 360 (Beckmann Instruments). Genotyping ... Genotyping DNA was extracted from white blood cells using standard methods. A mutagenically separated polymerase chain reaction (MS-PCR) was developed to separate wildtype (wt) and mutated alleles...
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Báo cáo Y học:Association of the thyrotropin receptor with calnexin, calreticulin and BiP Effects on the maturation of the receptor docx
... g.Immunoprecipitation and electrophoresisThe radiolabeled supernatant obtained was saved and incubated for 1 h at 4 °C with protein A- Sepharose and centrifuged for 2 min at 10 000 g. The supernatant wasincubated ... orCRT and the glycoprotein substrate. At the end of thepulse and at each chase time, cells were lysed and immunoprecipitation was carried out using mAb A1 0.The data obtained indicate that CST ... These data suggest that BiPhas a negative effect on the folding of TSHR. Theinteraction of this receptor with BiP leads to an increase in the degradation of TSHR and also to a decrease in theamount...
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Báo cáo Y học: Association of human tumor necrosis factor-related apoptosis inducing ligand with membrane upon acidification pdf
... 1343–1354.7. Kayagaki, N., Yamaguchi, N., Nakayama, M., Kawasaki, A. ,Akiba,H.,Okuma,K.&Yagita,H.(1999)InvolvementofTNF-related apoptosis-inducing ligand in human CD4+T cell-mediated cytotoxicity. ... observations, structuralchanges of TRAIL induced by acidification reveal thatTRAIL might have a potential acid-enhanced cytotoxicity and its intrinsic property be also shared by those of TNF -a and ... and PtdSer at acidic pH values. In many cases, the binding of a protein with lipid bilayer disrupts the bilayer integrity tomake the membranes permeable [30,31]. To ascertainwhether TRAIL alters...
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Báo cáo y học: "Association of Adiposity, Cardiorespiratory Fitness and Exercise Practice with the Prevalence of Type 2 Diabetes in Brazilian Elderly Women" pot
... triglycerides and C-reactive protein, lower levels of HDL, silent myocardial ischemia, neuropathy, peripheral arterial insufficiency, myocardial infraction, macrovascular disease, abnormal myocardial ... prevent diabetes in managed care and community setting [1, 22, 29]. Health professionals should encourage individuals of all ages to maintain an active life-style that can attenuate the negative ... inter-examinator variability, all anthropometrics measures were obtained by a single trained examiner. Body mass, height and waist circumference were assessed. Body Mass Index was calculated...
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Báo cáo y học: "Role of Genetic Polymorphisms in Therapeutic Response to Anti-Asthma Therapy" pot
... classes of asthma therapy, focusing on a potential genetic clue to medication response.Key words: asthma, genetic polymorphisms Our understanding of the pathophysiology and treat-ment of asthma ... specific class of asthma therapy.Several recent studies have highlighted phenotypic indicators of response.1,2As an example, in a recent study by Szefler and colleagues, it was found that baseline ... significant potential clinical consequences. In a studyby Martinez and colleagues, 269 children who were b2 naive,participating in a longitudinal asthma study, had theirbronchodilator response measured...
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