Báo cáo y học: "Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study" pdf
Báo cáo y học: "Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study" pdf
... Previously, Garred andcoworkers [23] showed that MBL2 exon 1 variant allele carrierstatus was associated with early age at onset of RA, which is the adult counterpart of polyarthritis [26]. Garred and ... and low expression of MBL. Theinfluence of the X /Y allele was also determined by studying six'extended' genotype groups: YA/YA, YA/XA, XA/XA, YA/O,XA/O and O/O.Statistical analysisData ... glomeruli can causehistological damage of kidneys, and activation of the lectin pathway by MBL can induce vascular tissue damage in myo-cardial ischemia-reperfusion injury and diabetes [42-44]....
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Báo cáo y học: "Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study" potx
... control group of patients with RA were analyzed twice with a 1-year interval.Table 2Clinical characteristics of patients at baseline and after 24 and 48 weeks of adalimumab treatmentVariable Week ... statisticallysignificant. Data were analyzed with SPSS statistical software10.00 for Windows (SPSS, Inc, Chicago, IL, USA). Statisticalanalysis was calculated by Last Observation Carried Forward(LOCF).ResultsResponse ... assay in early rheumatoid arthritisfor predicting five year radiographic damage. Ann Rheum Dis2003, 62:120-126.35. Bas S, Genevay S, Metyer O, Gabay C: Anti-cyclic citrullinatedpeptide antibodies,...
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Báo cáo y học: "Nucleosome rotational setting is associated with transcriptional regulation in promoters of tissue-specific human genes" pot
... critical reading of the manuscript and Yoichiro Nakatani and Shinichi Morishita for providing medaka TSS mapping data. This work is funded by the ATIP program of the Centre National de la Recherche ... CpG islands separate transcription start sites with and without the 10-bp RR periodic signal. (a, b) The 9,622 TSSs associated with a CpG island show a clear periodic signal (a) that translates ... same positional con-straints. Finally, our model predicts that modulating therotational orientation of a nucleosome may be an efficientmechanism to regulate gene activation, in a way that is epigenetically...
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Báo cáo y học: "Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis" pdf
... Kawanaka N, Yamamura M, Aita T, Morita Y, Okamoto A, Kawashima M, Iwahashi M, Ueno A, Ohmoto Y, Makino H: CD14+,Available online http://arthritis-research.com/content/9/3/R49Page 3 of 10(page ... results in itsautocatalysis and/or activation, and the induction of the degra-dative phase of apoptosis through the activation of caspases3 and 7 [23]. An additional pathway of death receptor-inducedcell ... Bcl-2expression of rheumatoid synovial fibroblasts. J Rheum 1996,23:1345-1352.6. Sugiyama M, Tsukazaki T, Yonekura A, Matsuzaki S, Yamashita S,Iwasaki K: Localization of apoptosis and expression of apopto-sis...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... generation of artefactsor are not easily measurable in accessible human samples,such as serum, plasma or urine [3,4].The measurement of peripheral anti-oxidants is an alter-native way of analysing ... [13] was used for Apolipoprotein E(APOE) genotyping.Statistical analysisNon-parametric analysis of variance (Mann-Whitney U-test) was applied to evaluate the differences in AOC con-centrations ... design of the study, performedAOC assay and prepared the manuscript; AG performedAOC assay and help to draft the manuscript; MP per-formed statistical analysis and help to draft the manu-script;...
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báo cáo hóa học:" Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy" potx
... Infectious Diseases, Indiana University School of Medicine,Indianapolis, IN, USAFull list of author information is available at the end of the articleGupta et al. Journal of the International AIDS ... was associated with higher mortality. In addition, a largeZambian study of nearly 26,000 patients initiating cART[6] found that 90-day mortality rates after cART initia-tion were signi ficantly higher ... in a substantial number of theUSAID-AMPATH enrollees, may limit generalizability.However, the very large sample size of the analysis cohort and its similarity to the excluded patients greatlymitigates...
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Báo cáo y học: "Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score" potx
... Stamm TA, Uffmann M, Smolen JS:Benefit of very early referral and very early therapy with dis-ease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology (Oxford) ... clinical assessmentsare needed [10-12]. For the purpose of disease activityACR = American College of Rheumatology; ANOVA = analysis of variance; APR = acute phase reactant; CDAI = Clinical Disease ... HealthOrganization–International League of Associations for Rheu-matology) core set variables of disease activity [13-15] areavailable, such as the Disease Activity Score (DAS) [16]. Alsoavailable are...
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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... statisticalanalysis of the data. All authors read and approved the finalmanuscript.AcknowledgementsThe authors wish to thank all participating community-based pharmacies in Enschede. The authors ... significantly with regard to thenumber of risk factors for NSAID -associated gastropathy, sug-gesting comparable risk profiles. Similarly, in a post hoc sub-group analysis for those taking either ... authors also wish to thank all participating physicians, especially those at the departments of Gastroenterology, Surgery and Internal Medicine, the nurses and physician assistants at the Depart-ment...
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Báo cáo y học: "Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease" potx
... electrocardiography and by Dop-pler cardiography, and was defined as pericarditis, anabnormal electrocardiography or cardiomegaly. Systolic pul-monary artery pressures of 40 mmHg and above determinedby ... with an increased risk of reduced nailfold capillary density when compared with systemic-sclerosis-related antibodies and markers for inflammatory activity. Inflammatory activity describes an ... fibrotic as well as vascular lung diseaseand vasculopathy in early SSc. IL-15 may contribute to thepathogenesis of SSc. IL-15 could also be a candidate biomarkerfor pulmonary involvement and a target...
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Báo cáo y học: "NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor" docx
... signaling pathways;an NF-κB pathway, a mitogen-activated protein kinase path-way, and a c-Fos pathway. RANKL also evokes Ca2+ oscilla-tion, which leads to calcineurin-mediated activation of NFATc1[13]. ... emulsion intrader-mally at the base of the tail. After 21 days (day 0), the sameamount of the antigen emulsified in the same adjuvant wasintradermally injected at the base of the tail as a booster ... theclassification of rheumatoid arthritis. Arthritis Rheum 1988,31:315-324.22. Nanki T, Nagasaka K, Hayashida K, Saita Y, Miyasaka N: Chemok-ines regulate IL-6 and IL-8 production by fibroblast-like...
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