Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc

... rise to proteins defective in ATM signalling in vivo [24]. Studies of linkage disequilibrium (LD) patterns of the ATM gene have revealed low recombination and extensive LD span-ning the whole gene, ... location of the identified variants along the gene as well as the exons rel-ative to the domains of the protein described by [17], suchas the PI3K domain, substrate binding domains and ATP-binding ... protein kinasedomain (PI3K-domain), 2) the substrate binding domain in the N-terminal of the protein necessary for activation of p53 in response to DNA damage, 3) the FAT domain –common for the...

báo cáo khoa học: "Chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence?" doc

... Margaritora1 and Pierluigi Granone1AbstractRecent efforts to improve survival in patients with locally advanced esop hageal carcinoma have combined bothsystemic and local therapy. However, the ... correct evidence and agreed guidelineswe consider the results from [1] of significant clinicalvalue and concur in advocating for further evidencestemming from large scale prospective randomised trials.Ideally, ... on the outcome of induction therapy (IT)plus surgery versus surgery alone in locally advancedoperable esophageal cancer (OC). The report is of great speculative interest given the consistently...

báo cáo khoa học: "Linkage disequilibrium populations between enzymatic loci in natural of Drosophila simulans" potx

... not found in the samples of D. simulares studiedhere, since the linkage disequilibrium between the two most frequent alleles, analogous to the predominant allels in D. melanogaster ... of 36, or 8 %). In bothcases, these are the kind of sampling variations that we would expect if there were no disequilibrium. The 36 ! produced by the testing of ... Aldox and Acph). The size of the samples (650 to 800gametes) and the choice of highly polymorphic loci allowed us to detect even weak linkage disequilibria, and to analyse...

báo cáo khoa học: "Linkage disequilibrium in French of Drosophila melanogaster" pot

... common...

Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt

... obtained in vivo with the endocannabinoid transporter inhibitor AM404 [38] and with the FAAH inhibitor URB597 [39], thussuggesting the contribution of anandamide to the beneﬁcial effects of CBs ... measure the brain levels of the endocannabinoids AEA and 2-AG and (c) to explore the changes in gene expression of CB1 and CB2 receptors. Earlier reports had shownthat D9-THC may be toxic when administered ... toxic effects of drugs interacting withcannabinoid receptors or have measured the brain levels of endocannabi-noids in in vitro and in vivo models of cerebral ischemia. The results of these studies...

Báo cáo khoa học: Distinct but critical roles for integrin aIIbb3 in platelet lamellipodia formation on ﬁbrinogen, collagen-related peptide and thrombin pot

... conformationalchange in the extracellular domain, leading to anincrease in afﬁnity, thereby promoting integrin–ligandinteractions [2]. In turn, clustering of integrins gene- rates a series of intracellular ... though they bind to distinct classes of surface receptor. This raises the ques-tion of the molecular basis of adhesion to these ligands and whether they induce distinct patterns of change in morphology. ... integrin activation, in view of the critical role of integrins in mediating adhesion and cell spreading. To address this, experiments were designed to compare the role of the major platelet integrin...

Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx

... disease) gene at the androgenreceptor in 1991 [1], followed by the Huntington’sdisease (HD) gene in 1993 [2], and the cloning of the spinocerebellar ataxia type 1 gene [3], the expandedpolyglutamine ... SCA1 pointing to serinekinase inhibition as a therapeutic strategy, and clini-cal success with the treatment of SBMA by leupro-relin, underscore the importance of analysis of huntingtin toxicity ... of the hall-marks of HD in humans, but not as much in mousemodels, is the striking loss of the striatum, and up to 30% of total brain mass, prior to death [31]. In the neurons that remain to...

báo cáo hóa học: " Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment" ppt

... has to beresponsive to meaningful changes in health in the patient population under investigation. The aim of this study was to investigate the responsiveness of the EQ-5D in breast cancer patients ... wereincluded in the trial after finalizing treatment and aftergiving written informed consent. Treatment included sur-gery and/ or radiotherapy and/ or chemotherapy. Follow-up appointments took ... measurements due to either randommissings within the instruments (n = 19) or because theywere a study drop-out (n = 10). A total of 192 patients were therefore included in the analysis. Their demo-graphic...

Báo cáo khoa hoc:" Potential benefit from using identified major gene in BLUP evaluation with truncation and optimal selection" ppt

... OF would lead to an increase in the numbers of individuals to be selected and thistogether with the smaller effect of the major gene would retard the fixation of the ... reduction in the weight given to the major gene relative to the polygenes, resulting in agreater intensity of selection applied to the polygenes and thus reducing the potential ... was to investigate, using stochastic simulation, the value of including genotype information for an identified major gene in the estimation of breeding values for increasing...

Báo cáo khoa học: " Hepatitis C Virus entry: the early steps in the viral replication cycle" ppt

... with other transmembrane proteins and regulate post-ligand binding events, including integrin-mediated adhesion strengthening. The c-terminus of CD81, CD151, and other tetraspanins meet the criteria ... expressed in a claudin-7 background. Of the 5 residues that differbetween the claudin-1 and claudin-7 in the n-terminal 1/3 of ECL1, 2 were found to be important in regard to HCVpp infection. The introduction ... of eIF2Met-tRNAGTP and the formation of a 48S-like com-plex at the initiation codon of the HCV RNA. The final and rate limiting step is the GTP-dependent association of the 60S subunit to form the 80S...

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