Báo cáo y học: "Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling" pps
Báo cáo y học: "Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling" pps
... waselevated on day 3 in tibial cartilage and on days 3 and 7 in patellar cartilage, but no longer was by day 21. IncreasedNITEGE staining (indicating aggrecanase activity) was found ondays 7 and ... production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodelingEsmeralda N Blaney Davidson, Elly L Vitters, ... mRNA expression hadincreased on days 7 and 21. BMP-2 overexpression alsoinduced increased aggrecan degradation in cartilage. VDIPENstaining (indicating matrix metalloproteinase activity) waselevated...
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Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
... directly but instead acts as a cofactor for the clea vage and activation of PAR4 [27].Thrombin has been shown t o cleave and a ctivate PAR1,PAR3 and PAR4, whereas trypsin cleaves and activatesPAR2. ... these pathwayshas a modulatory r ather than a mandatory role to play in mediating the proliferative response. In contrast, a recentreport has shown that tryptase induces DNA synthesis in canine ... ignalling pathways and intermediates suchas Ca2+mobilization, the E RK pathway, PtdIns 3-kinase and protein kinase C h ave all been identified a s mediators ofproliferative signals in a variety...
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Báo cáo y học: "Variations in brachial plexus and the relationship of median nerve with the axillary artery: a case report." pps
... reportVariations in brachial plexus and the relationship of median nerve with the axillary artery: a case reportSuruchi Singhal*, Vani Vijay Rao and Roopa RavindranathAddress: Department of Anatomy, ... Anatomy, St John's Medical College, Bangalore – 560034, IndiaEmail: Suruchi Singhal* - suruchisinghal@yahoo.com; Vani Vijay Rao - vanivijay03@yahoo.co .in; Roopa Ravindranath - roopar@yahoo.co .in * ... median nerve [12]. In a study doneby Pandey and Shukla on 172 cadavers, in 8 cadavers, themedian nerve was formed medial to the artery and traveled as such [13]. Anomalous branches of lateral...
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Báo cáo y học: "Elevated matrix metalloproteinase-9 in patients with systemic sclerosi" doc
... tissue characterized by microvacular damage and excessive fibrosis in the skin and internal organs, includingthe heart, lungs, and gastrointestinal tract. One of the majorhallmarks of the disease ... measured by gel zymographyWe used gel zymography to study sera of 20 SSc patients and 10 healthy controls, all selected unsystematically, toascertain the serum gelatinase activity of MMP-9. As canbe ... significantly.Clinical and laboratory evaluationClinical and laboratory assessments were done at the timeof sampling. The clinical variables were age, sex, diseaseduration, type of SSc [25], modified Rodan...
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Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"
... Mukawa H, Tomida T, Suzuki T, Kamiya H, Matsui H, Hayakawa T. Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary ... were transformed logarithmically to approximate normal distribution, and such data were analysed statistically. Statistical analysis of the data analysis was carried out using the ANOVA test. ... department in Alexandria University, and her main research interest is Molecular Chemical Pathology. Safaa El-Hifni (MBCHB, MSc, PhD, MD) is an emirates professor in Clinical Pathology at Alexandria...
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Báo cáo khoa học: D1 – Extracellular Matrix Proteins docx
... isoenzyme ADA1 and iso-enzyme ADA2. ADA1 and ADA2 differ in kinetic and immuno-chemical properties and probably are coded by separate geneticlocus. ADA2 is a minor component of ADA activity in ... Biologicas, Madrid,Spain,3Vacular Pathology, Departament of de Physiology and Pharmacology, University of Salamanca, Salamanca, Spain,4Vas-cular Biology, Department of Bioquimica y Biologı´ a ... Biochemistry National Academy of Sciences of Republic ofArmenia, Yerevan, Armenia. E-mail: hayk@web.amAdenosine deaminase (ADA, EC 3.5.4.4) deaminates (deoxy)adenosine to (deoxy)inosine. ADA is...
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Báo cáo y học: "Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium" potx
... have a role in maintaining active RA. The increase of both xIAP and survivin in active RA synovial tissue may be even more signifi-cant because of the known synergy of survivin and xIAP form-ing ... sections and formalin-fixed paraffin-embedded tissuewere prepared from the synovial biopsies. When available, anadditional synovial biopsy was placed into RNAlater (Ambion,Foster City, CA, USA) and ... (DR5) that is functionally active. ArthritisRheum 2004, 50:2786-2793.20. Miyashita T, Kawakami A, Nakashima T, Yamasaki S, Tamai M, Tan-aka F, Kamachi M, Ida H, Migita K, Origuchi T, Nakao K,...
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Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
... Hata K, Andoh A, Shimada M, Fujino S, Bamba S, Araki Y, OkunoT, Fujiyama Y, Bamba T: IL-17 stimulates inflammatoryresponses via NF-κκB and MAP kinase pathway in humancolonic myofibroblasts. ... revealed that both synovial fibroblasts and T cellsparticipate in the perpetuation of joint inflammation as dynamicpartners in a mutual activation feedback, via secretion ofcytokines and chemokines ... proinflammatorymediator participates in the activation of synovial fibrob-lasts in inflamed RA joints.Materials and methodsReagentsRecombinant human IL6, IL-8, IL-15, IFN-γ, transforminggrowth...
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Báo cáo y học: "Lack of autoantibody production associated with cytomegalovirus infection" pdf
... orchi-square analysis. Regression analysis was performedusing Sigma Plot (version 1.02; Jandel Corporation, SanRafael, CA, USA).ResultsAntibodies against Sm and RNPUsing the manufacturer’s sera ... myosin: a model for the study of molecularmimicry in the pathogenesis of viral myocarditis. Immunology1992, 75:513-519.7. Toyoda M, Galfayan K, Galera OA, Petrosian A, Czer LS, JordanSC: Cytomegalovirus ... and quantitated colorimetrically (Varelisa; Pharmacia& Upjohn, Freiburg, Germany). Sera were diluted 1:101 for both assays.The Sm antigen used in this assay was purified from calfthymus....
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Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx
... for some inflammatory mediators.Cell survival is essential for ensuring ongoing homeostaticmaintenance of cartilage and for bringing about repair todamaged cartilage. Maintaining integrity of ... aggrecan and type II collagen mRNA by TNF-α and EGF individually, addi-tional signals beyond the MAPK pathway are probablyinvolved when the factors are combined.The intracellular signals that ... apoptosis were assayed by immunoblot with an antibody specific for intact and cleaved forms of poly(ADP ribose) polymerase (PARP). No cleavage of PARP (i.e. appearance of a band at 89 kDa) was detected...
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