... wasalso induced by budesonide (Fig. 7B). In addition, RU486was also efficient at inducing GR nuclear translocation,indicating that binding of the antagonist can result in dissociation of the ... relevant prostaglandins, includingprostaglandin E2(PGE2), which is the major prostaglan-din product of both airway epithelial and A549 cells [5]. In inflammation, the inducible COX, COX-2, ... levels of prostaglandins [4]. Conversely, COX-2 expression is highlysensitive to glucocorticoid inhibition, suggesting thatinhibition of COX-2 is critical in t he repression of prostaglandins...