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Báo cáo y học: "The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden" pdf

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Báo cáo y học: "Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population" docx

... primary knee OA, andgenetic variations in the ER-α gene may be involved in OA.Keywords: estrogen receptor, haplotype, knee osteoarthritis, polymorphism IntroductionOsteoarthritis (OA) is a ... associationstudy in patients with primary knee OA (n = 151) and healthyindividuals (n = 397) in the Korean population. Haplotypinganalysis was used to determine the relationship between threepolymorphisms ... [15].Our study showed that the genotype distributions for theintron 1 T/C PvuII and the intron 1 A/G XbaI polymorphismswere not associated with OA, a finding similar to thatreported by Loughlin and...
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Báo cáo y học: "Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome" pot

... been reported in association with many rheumatic diseases, most commonly in systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is similar to hemophagocytic lymphohistiocytosis (HLH), ... joints involved), polyarticular(five or more joints), and systemic. The systemic onset form, with its markedly febrile presentation, is certainly the mostdistinct clinical subtype of the disease. ... (or histiocytes) actively phagocytosing hemat-opoietic elements. Although MAS has been increasinglyrecognized in association with almost any rheumatic dis-ease, it is by far most common in the...
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Báo cáo y học: "Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study" pdf

... articleMannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort studyKoert M Dolman1,2, Nannette Brouwer2, Florine NJ Frakking1, ... Jacobsen S: Geneticallydetermined high serum levels of mannose-binding lectin andagalactosyl IgG are associated with ischemic heart disease in rheumatoid arthritis. Arthritis Rheum 2007, 56:21-29.42. ... association with disease parametersPolyarthritis group In the 67 patients with polyarthritis, patients in the low MBL2genotype group were younger (4.4 years, IQR 3.6 to 7.0years) at onset of disease...
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Báo cáo y học: "Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells" pdf

... Erythematosus Disease Activity Index-2,000 (SLEDAI-2000) and analyzed usingy Spear-man's test. IFIT4, interferon-induced protein with tetratricopeptide repeats 4.Available online http:/ /arthritis- research.com/content/10/4/R91Page ... Taylor M, Brahn E, Hahn BH, Tsao BP: Associationof increased interferon-inducible gene expression with dis-ease activity and lupus nephritis in patients with systemiclupus erythematosus. Arthritis ... treated with IFN-α2a for 72 hours was examined by (e) flow cytometry with intracellular staining or (f) Western blotting with β-actin as a protein loading control. The experiments were performed...
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Báo cáo y học: "The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden" pdf

... Rantapaa-Dahlqvist S: PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for thedisease. ... stratified according to autoantibodyTable 2Frequency distribution of the 1858 C/T polymorphism of PTPN22 in patients with early rheumatoid arthritis and matched controlsGenotype Patients (n ... associated with several autoimmune diseases including rheumatoid arthritis (RA). We have shown that carriage of the T variant (CT or TT) of PTPN22 in combination with anti-cyclic citrullinated peptide (anti-CCP)...
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Tài liệu Báo cáo Y học: The Ikaros family protein Eos associates with C-terminal-binding protein corepressors pptx

Tài liệu Báo cáo Y học: The Ikaros family protein Eos associates with C-terminal-binding protein corepressors pptx

... beinvolved in the interaction. In this way, it seems likely thatproteins such as Eos may be able to bind to CtBP that is already associated with another PXDLS motif-containingprotein. For instance, ... analysis of Ikaros has indicated that it containsdistinct domains that are implicated in activating orrepressing transcription [4,5,19,33]. One discrete domainwithin the N-terminus contains ... CtBP can also bind sites withinthe N-terminal domain of Eos.TRPS1 interacts with CtBPThe TRPS1 protein is a multi-(zinc finger) protein thatcontains two C-terminal fingers highly related to the...
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Báo cáo Y học: The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells potx

Báo cáo Y học: The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells potx

... determinedby spectrophotometry at 260 nm, and its integrity wasassessed by agarose gel electrophoresis. PolyadenylatedRNA was prepared by oligo(dT) affinity chromatographyusing the PolyATract System ... Mer.Keywords:E2F;Mer gene; receptor tyrosine kinases; Sertolicells; Sp1 and Sp3.Receptor tyrosine kinases (RTKs) are cell surface receptorsthat contain intrinsic protein tyrosine kinase activity ... introduced into the Sp1 cis-actingmotifs, we have shown that the protein-binding sitesituated at )194/)164 is not merely a result of directbinding of Sp1 or Sp3, but that it may involve binding...
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Báo cáo Y học: The Emery–Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A pptx

Báo cáo Y học: The Emery–Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A pptx

... phosphorylation at resi-due S49 is unlikely to directly regulate emerin-laminA ⁄ C interaction in vivo.Protein kinase A-dependent phosphorylation ofserine 49Computer prediction analysis using ... Expressing emerin 1–220 in our insect cell expression system resulted in verylow yields with 50% of the protein insoluble, but mul-tiple bands were apparent from immunoblotting with the antiemerin ... describing the isolation of a large proteincomplex consisting of PKA, the A-kinase anchoringprotein AKAP149, protein phosphatase 1, nuclearlamins, emerin and actin from both differentiatingmyoblasts...
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Báo cáo Y học: The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider pptx

Báo cáo Y học: The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider pptx

... of the hydrophobic-hydro philicbalance in those highly cationic peptides is the key point foractivity. This viewpoint has to be t aken with cau tion; in some cases, as with tachyplesins, the ... BrazilGomesin is the first peptide isolated from s pider exhibitingantimicrobial activities. This highly cationic peptide is composed of 18 amino-acid residues including four cysteinesforming two disulfide ... whencompared, peptides with a high content of hydrophobicresidues are more hemolytic [41]. In this respect, thedifferent levels of hemolytic activity in androctonin, gome-sin and protegrin could be linked...
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Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"

... level of leptin, insulin and cytokines but findings are not con-sistent (21-24). Alternatively, several studies showed that TNF levels were not increased during interferon therapy and postulated ... (57%) with the mean age of 52.5 years (Table 1). Fifty six percent were infected with genotype 1, 16% with genotype 2 and 28% with genotype 3. Clinical char-acteristics, relevant laboratory data ... postulated other mechanisms of weight loss including changes in level of leptin and insulin which affect glucose metabolism (21, 22). In our stud-ies, weight loss usually began within the first few...
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