Báo cáo y học: "Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter" docx
Báo cáo y học: "Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter" docx
... neuropathyconfirmed by electromyography, or the diagnosis of Sjögrensyndrome based on the clinical symptoms of dry eyes and drymouth (confirmed by a positive Schirmer's test and/ or kerato-conjunctivitis ... kerato-conjunctivitis sicca with involvement of salivary glands docu-mented by positive lip biopsy and/ or salivary scintigraphy).Simple x-rays of the hands and feet were analyzed with the Sharp/van der Heijde ... necessary todetermine whether the previously identified TNF-α gene pro-moter variants contribute directly to RA outcome or act as genetic markers of other polymorphisms in the TNF-α gene promoter...
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Báo cáo y học: "Fluvoxamine for aripiprazole-associated akathisia in patients with schizophrenia: a potential role of sigma-1 receptors" ppt
... in the treatment of akathisia, they showonly a moderate efficacy, and a substantial proportion of patients fail to respond to treatment. In contrast, under-standing of the pathophysiology of ... with atypical antipsychotic drugs. Although understanding of the pathophysiology of akathisiaremains limited, it seems that a complex interplay of several neurotransmitter systems might play a ... furuse@asahikawa-rch.gr.jp1Department of Psychiatry, Asahikawa Red Cross Hospital, Asah ikawa, JapanFuruse and Hashimoto Annals of General Psychiatry 2010, 9:11http://www.annals-general-psychiatry.com/content/9/1/11©...
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Báo cáo Y học: Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces docx
... a purity of 80–90% for the total annexin II asjudged by SDS/PAGE.Cleavage of annexin II by MMPs and determina-tion of N-terminal amino acid sequence The proforms of matrilysin and other MMPs ... activates the proforms of these MMPs by producing plasmin[47]. Thus, the cleavage of annexin II by matrilysinmay trigger the proteinase amplification cascade orcycling in the pericellular space of cancer ... membranes.Although we cannot exclude the possibility that tPAbinds to the C-terminal lysines of other protein frag-ments that are produced by the matrilysin activity, the result of the siRNA experiment with...
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Báo cáo y học: "Estimated intelligence quotient in anorexia nervosa: a systematic review and meta-analysis of the literature" pot
... estimate of the results of a particular study; specifically it shows how the effect size of the study varies from zero. The size of the square shows the weighed individual contribution of the study ... data synthesis, supported general analyses and interpretation of data, and contributed to drafting the manuscript. DS contributed to the design of the study, performed the statistical analyses, ... neuropsychology in AN, the present systematic review focused on AN only.AN is the most severe ED affecting mainly, but notonly, young women, and has the highest rate of mortalitylinked to a psychiatric...
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Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx
... regulatory pathways described for IL-18. High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early clinical studies to establish the safety of ... components of CommentaryInterleukin-18: a therapeutic target in rheumatoid arthritis? Iain B McInnes, Foo Y Liew and J Alastair GracieDivision of Immunology, Infection and Inflammation, University of ... considered the primary target, expressionelsewhere in the circulation and in the lymphoid systemmay also be therapeutically important – we recentlyreported IL-18 expression in human lymph node,...
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Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte" ppt
... cells, and travel to the synovial membrane where they might appear astype B synoviocytes and promote synovitis [23]. Alternatively,they could travel via the systemic circulation to the subchondral ... link the entity of bone oedemawith current theories of the immunopathogenesis of RA.Hirohata and colleagues [23], in a highly accessed articlepublished in Arthritis Research and Therapy in ... examinations of the spine in patients with ankylosingspondylitis, before and after successful therapy with inflix-imab: Evaluation of a new scoring system. Arthritis Rheum2003, 48:1126-1136.7. Hoy G,...
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Báo cáo y học: "Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis" ppsx
... fluid IgM reactivity to aggre-can by 21% (p < 0.05) and by 22% (p < 0.01), respectively.On the contrary, neither of the glycosidase cleavages affectedreactivity of IgM-type control serum ... highly significant (three-factor ANOVA, F = 30.17 DF = 1.11 p < 0.001), and independent from type of the antigen and from the type of the antibody as well. Arthritis Research & Therapy Vol ... American College of Rheumatology (ACR) [12].Patients were treated in the Department of Rheumatology,Semmelweis University, and the National Institute of Rheuma-tology and Physiotherapy, both in...
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Báo cáo y học: " Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses'''' Health Study II" pot
... focused set of analyses that test for heterogeneity interms of the timing, type, and severity of the trauma. Wehypothesize that the effect of PTSD genetic risk variantswill be magnified among ... correcting for all testsin a particular gene- by -gene comparison, and also at the experiment-wide level. The standard SNP-by-SNPapproach yields powers of 24% and 6% respectively,whereas the new approach ... numbers from their survey,we have telephone numbers for over 62,000 of the studymembers and can access numbers for most of the rest of the cohort by sending a computer tape of names and addresses...
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Báo cáo y học: " Evidence for genetic association of RORB with bipolar disorder" pptx
... and is highest in the eye, pin-eal gland, and brain, particularly in the primary sensorycortices (layer IV of the somatosensory cortex) and the suprachiasmatic nuclei of the hypothalamus (reviewed ... al.: Fur-ther evidence for family -genetic risk factors in attention def-icit hyperactivity disorder. Patterns of comorbidity inprobands and relatives in psychiatrically and pediatricallyreferred ... 2Department of Biology, Indiana University, Bloomington, IN, USA, 3Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA, 4Laboratory of Neurophenomics, Department of Psychiatry,...
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Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... values. The development of sepsis from a localized infection isa dynamic continuum and in the majority a sequelae of CAP [54]. The severity of a disease determines the con-sumption of costly and ... scores.Discriminatory power of biomarkers for predictingdeath ranged between 0.60 for PCT to 0.76 for proADM and 0.79 for proANP. CURB65 and PSI score had AUCs of 0.74 and 0.84, respectively. Again, the best ... any involvement in design and conduct of thisstudy, namely, the collection, management, analysis, and interpretation of the data; and preparation, decision to submit, review, or approval of the...
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