Báo cáo khoa học: " A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI" pptx

... this article as: Meyzer et al.: A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced ... by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRICandice Meyzer1, Frédéric Dhermain2,3, Denis Ducreux3, Jean-Louis ... from the par-ents and the patient for publication of this case report and accompagnying images. A copy of the written con-sent is available for review by the Editor -in- Chief of thisjournal.Author...

Báo cáo khoa học: Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2¢ of substrates pdf

... gran-zyme B was altered so that it cleaved after an aromaticamino acid instead of Asp by a single Arg226 ﬁ Glymutation [15]. A preference for basic amino acids wasseen when Arg226 was replaced ... was replaced by an aminoacid with an uncharged side chain, a preference for mainly aliphatic amino acids was observed. However, a weak preference for acidic P2¢ amino acids stillremained for ... together as follows:aromatic amino acids (Phe, Tyr, and Trp); negativelycharged amino acids (Asp and Glu); positively chargedamino acids (Lys and Arg); small aliphatic amino acids(Gly and Ala);...

báo cáo khoa học: " FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90yttrium ibritumomab tiuxetan consolidation for the treatment of relapsed grades 1 and 2 follicular lymphoma: a report of 9 cases" pot

... thank Dr. Diana Giannarelli of the Department of OncologyRegina Elena National Cancer Institute for statistical analysis.Author details1Department of Hematology Regina Elena National Cancer ... follicular lymphoma: a report of 9 casesFrancesco Pisani1*, Carlo Ludovico Maini2, Rosa Sciuto2, Laura Dessanti1, Mariella D’Andrea1, Daniela Assisi3,Maria Concetta Petti1AbstractBackground: ... fr.pisani@tiscali.it1Department of Hematology Regina Elena National Cancer Institute, Via ElioChianesi, 53 00128 Rome, ItalyFull list of author information is available at the end of the articlePisani...

Báo cáo khoa học: Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1 doc

... Kurokawa, Imizu, Toyama, JapanFax: +81 766 56 2498Tel: +81 766 56 7500E-mail: tsakaki@pu-toyama.ac.jpDatabaseStructural data are available in the ProteinData Bank database under the accessionnumbers ... Miyazaki A, Saito M, Adachi T, Mizoue K,Hanada K & Omura S (1992) Transformation of vita-min D3 to 1 alpha,25-dihydroxyvitamin D3 via25-hydroxyvitamin D3 using Amycolata sp. strains.Appl ... sites, was prepared using the primers 5¢-ACCAAGCTTATGAAAAGATACCGCCAC-GACG-3¢ and 5 ¢-TTCTGCAGTCACCAGGTGACCGG-GAGTTCG- 3¢, and the expression plasmid for R73V ⁄ R8 4A in E. coli cells as a template...

Báo cáo khoa học: Cytosol–mitochondria transfer of reducing equivalents by a lactate shuttle in heterotrophic Euglena docx

... affected by mersalyl, but instead it was strongly inhibited by oxalateand oxamate. The inability for aerobe pyruvate oxidation in Euglena[4,14] makes evident the advantage of having a lactateshuttle ... that the reversereaction of the plasma membrane lactate transporter wasnegligible. In this regard, the accumulation of intracellularproline and the growth rate of Saccharomyces cerevisiaeinversely ... at25 °C. The rate of respiration was determined in the presence of the indicated additions, as described in the Materials and methods. Oxa-late was added after the oxidizable substrate. Additions:...

Tài liệu Báo cáo khoa học: Altered inactivation pathway of factor Va by activated protein C in the presence of heparin doc

... initial cleavage at Arg306 (pathway 1), after whichArg506 can be cleaved, resulting in the formation of a 30 kDa fragment.Kinetic analysis of cleavage of FVa at Arg506 by APCTo further characterize ... monoclonal antibody (AHV 5146) against the FVa heavychain was used to visualize the inactivation fragments. In the absence of heparin, the transient 75 kDa fragmentrepresenting the heavy chain fragment ... characterize the inhibitory effect of heparin on the Arg506 cleavage, we performed a kinetic analysis by using nonlinear regression analysis of initial rates of FVainactivation by APC (initial...

Tài liệu Báo cáo khoa học: The swinging movement of the distal histidine residue and the autoxidation reaction for midge larval hemoglobins docx

... Biology, Nakayama-Yoshinari, Sendai, JapanSome insects have a globin exclusively in their fast-growinglarval stage. This is the case in the 4th-instar larva of Toku-nagayusurika akamusi, a common ... (4–12) and in the presence of 1mMEDTA. For example, a 1-mL solution containing0.2Mappropriate buffer and 2 mMEDTA was placed in a test tube and incubated in a water bath maintained at25 ... such as the one that can play a dominant role in the autoxidationreaction of most mammalian myoglobins or hemoglobinshaving the usual distal histidine residue. Instead, Ta-VHbO2contained a...

Tài liệu Báo cáo khoa học: Kinetics and thermodynamics of nick sealing by T4 DNA ligase pptx

... kineticanalysis of the overall ligation reaction and an initialthermodynamic characterization of the catalysis. We aimedto achieve the following goals: (a) to deepen the generalunderstanding of the ... min)1, Table 1). The increase in the joining rate of M5C19 at low [ATP] mayindicate a shift of equilibrium towards the catalyticallycompetent nonadenylated form of the enzyme.At [ATP] above ... contrast, an approximately twofoldincrease in the joining rate is observed, compared withmore than 10-fold decrease in the latter in the case of C24. In the case of M5C19, formation of the phosphodiesterbond...

Báo cáo khoa học: Uptake and metabolism of [3H]anandamide by rabbit platelets Lack of transporter? ppt

... coupled to the activity of intracellular FAAH [23,24]. FAAH is responsible for the catabolism of anandamide and it contributes toanandamide uptake by making and maintaining a concen-tration gradient ... mL water in 1 Ldioxan) as the scintillation ﬂuid. The liquid scintillationcounter used was a Wallac 1209 Rackbeta, Pharmacia.Inthesamemanner ,for[ 3H]anandamide accumulationexperiments, after ... and reached a plateau after 10–20 min. Interestingly, no initial increase in free fattyacid was detected ( 2% after 2 min, and reached a plateau ( 5%) after 20 min) (Fig. 4).Results obtained...

Báo cáo khoa học: Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase ppt

... soman. In the case of symmetric OPs such as DFP, ChPo,paraoxon and parathiol, the acetylcholinesterase inhibi-tion assay reflects the rate of both degradation anddetoxification. The rates of detoxification ... detoxification of soman andcyclosarin catalyzed by Ps. diminuta OPH, squidDFPase and PON1 shown in Fig. 1 were determined by calculating the initial rates of hydrolysis. The initialrate (kobs) ... activity. The changes in activity of each variant towarddegradation of paraoxon and parathiol are expressed by the ratiok2(mutant) ⁄ k2(wild-type) drawn on a logarithmic scale.Table 2. Comparison...

Xem thêm