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Báo cáo khoa học: " Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditions" potx

Báo cáo khoa học:

Báo cáo khoa học: " Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditions" potx

... apoptosis inducing antibodies with irradiation strongly increases long- term tumour control. Sincemurine long- term control experiments are the only cur-rently accepted functional approach to ... irradiation (5× 3 Gy, d1-5) and lexatumumab (0.75 mg/kg, d1, 4 and 8). The tumour bearing hind limbs were irradiated with graded single top up doses at d8 under normoxic (ambient) and acute hypoxic ... with irradiation reduces tumour regrowth and leads to a highly increased local tumour control in a nudemouse model. This substantial effect was observed under ambient and more pronounced under hypoxic conditions.BackgroundLexatumumab...
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Báo cáo khoa học: " Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model" docx

... liver,skin and heart [16-18,23-26]. Therefore, together with data on radiation induced PDGF expression and phos-phorylation of PDGFR in vitro and in vivo, and the inhibi-tion by the kinase inhibitors, ... mouse survival following thoracic irradiation and imatinib treatmentFigure 1(a) Kaplan-Meier analysis of mouse survival following thoracic irradiation and imatinib treatment. Death was considered ... anterior and posterior regions and the left lower anterior and pos-terior regions. Total arithmetic means ± SE of the HU werecalculated.StatisticsMouse survival curves after thoracic irradiation and...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

... needs to Fig. 2. TH and DO activities in extracts of wild-type R3 R. solana-cearum and two mutant strains with mutations in the PPO genesRSc0337 and RSc1501. TH activity was determined at pH 5 and 0.05% ... strengthwas increased with a salt gradient of NaCl up to 1.5 m to elute proteins bound to the anionic gel. Fractions of1.9 mL were collected, the protein content was monit-ored (A280), and TH and ... R3. The PCR product with a size of  1.6 kbwas digested with BamHI to obtain a fragment betweenthe two copper-binding site coding regions and ligated to pBlueScript pKSII(+) with T4 DNA ligase...
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báo cáo khoa học: " Threshold models with heterogeneous residual variance due to missing information" doc

... considered, and the modelfor the underlying variable is :1Above, s; and 2 s! are the random effects of sire i and maternal grandsire j,2 frespectively. Under additive ... grandsire model. This can be written as :where Y¡jk is an observation on individual k, with sire i and maternal grandsire j. Thescalars s; and 2 1 s, are the random ... random effects of sires and maternal grandsires, respectively, and (3 is a vector of fixed effects, which relate to Y¡jk via the incidence vector xii,. Inpractical applications,...
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Báo cáo khoa học: The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles Ser195 and Cys145 are predicted to be the active site nucleophiles pot

Báo cáo khoa học: The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles Ser195 and Cys145 are predicted to be the active site nucleophiles pot

... acyl-enzymeintermediates, and tetrahedral ( 109.5°) water-bondedintermediate. In contrast, serine and thiol protease and amidase are confined to interacting with planar sub-strates and tetrahedral intermediates ... containing asecond CX3C motif. From top to bottom (with database accession numbers in parentheses): Sulfolobus solfataricus (P95896); Pseudomonassyringae pv. tomato str. DC3000 (AAO55930); Pseudomonas ... solfataricusbelongs to the CX3C subgroup of enzymes cleaving bothamides and nitrilesSer195 and Cys145 are predicted to be the active site nucleophilesElisa Cilia1,2, Armando Fabbri1,...
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Báo cáo khoa học: "Application of deltamethrin for spraying or dipping to protect Scots pine seedlings against Hylobius abietis L and logs against Tomicus piniperda L" ppsx

... 1986 and 2 in 1987) thenumber of living beetles on a 1-m long sec-tion of treated wood varied from 0.55 to 2.11 and the number of dead beetles var-ied from 1.82 to ... 2.5-6g of active ingredient per ha in the control of leaf eating larvae, especially speciesbelonging to the Lepidoptera and Hyme-noptera families. At higher doses it ... wood against the barkbeetle and the control of the pine weevil inpine plantations.EXPERIMENT WITH T PINIPERDAWood is generally protected from Tomicuspiniperda L, the larger...
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Báo cáo khoa học: Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate doc

Báo cáo khoa học: Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate doc

... rate and extent of saporin entry into the cytosol, which in turngreatly enhanced toxin potency.Dimethylsulfoxide treatment does not inducesubstantial sensitization to other toxins To determine ... monensin and chloroquine on theendocytosis and toxicity of chimeric toxins. Cell MolLife Sci 54, 866–875.11 Cavallaro U & Soria MR (1995) Targeting plant toxins to the urokinase and alpha ... passage into thecytosol remains a poorly understood process.Both saporin and anticancer saporin conjugatesenter the target cell by endocytosis and then escape theendomembrane system to reach...
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Báo cáo khoa học: "Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis" docx

... median OS with the combinationtherapy (docetaxel and S-1) to that in the control arm (S-1 alone). In total, 638 patients were enrolled (the originalTable 3: Hematologic and non-hematologic toxicitiesGrade ... (4.7%) and anemia (1.2%),which occurred in 55.6% (40/72) within three cycles.However, the hematological and non-hematological tox-icities were both tolerable, except in one case which dieddue to ... study were to retrospectively clarify the efficacy and toxicities of thedocetaxel and S-1 combination as a first-line treatment for patients with advanced or recurrent gastric cancer and to analyze...
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Báo cáo khoa học:

Báo cáo khoa học: "Surgical treatment for locally advanced lower third rectal cancer after neoadjuvent chemoradiation with capecitabine: prospective phase II trial" pptx

... 2).Toxicity was moderate and summarized in table 4. Nohematological grade 3 or 4 toxicities occurred. Hemato-logical toxicity was mild with grade II anemia in 4 patients(9.3%, 95% CI 3–23), and ... rectum needs a long- course of neoadjuvant treatments to reduce tumor volume, to induce down-staging that increases circumferential resection margin, and to facilitate surgery.Aim: To evaluate the ... to reduce the inci-dence of local recurrence. This option is based on theknowledge that irradiation before surgery is more dose- and cost-effective than postoperative irradiation and lesstoxic....
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Báo cáo khoa học: "Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis" docx

... tumor. At laparotomy, the patientunderwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, radical rightnephrectomy with lymphadenectomy, and left hepatectomy. Pathology ... reportSurgical treatment of a rare primary renal carcinoid tumor with liver metastasisRoberto Gedaly*1, Hoonbae Jeon1, Thomas D Johnston1, Patrick P McHugh1, Randall G Rowland2 and Dinesh ... cases.Metastases to the bone and spleen were also described butwere much less common. Surgery was considered the treatment of choice for RCT, and long- term survival wasachieved even in patients with lymph...
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