Báo cáo khoa học: "High-dose rate brachytherapy (HDRB) for primary or recurrent cancer in the vagina" docx

... guidance was used for tumors involving the vaginal apex to avoid injury to the bladder or adjacent small bowel. CT simulation for inter-stitial brachytherapy planning was performed and the dose was ... withinterstitial brachytherapy have reported data using low-dose -rate brachytherapy (LDRB) [2-9]. There have beenonly few series using high-dose -rate brachytherapy (HDRB) for vaginal tumors ... 3 or higher morbiditywas noted.DiscussionRadiotherapy is the main therapeutic modality in the management of primary or recurrent vaginal cancer. Brachytherapy remains integral part of definitive...

Tài liệu Báo cáo khoa học: "Phrase-Based Backoff Models for Machine Translation of Highly Inﬂected Languages" docx

... training and after gener-ating the output in the target language. Normaliza-tion of English/German in ectional morphologyto base forms for the purpose of word alignment isperformed in (Corston-Oliver ... translate unseen word forms in the foreign lan-guage input. When a match for an unknown word in the test set cannot be found in the trained phrasetable, the model relies instead on translation ... by preprocessing the test data accordingly. The phrase table willthus include entries for phrases based on full wordforms as well as for their stemmed and /or splitcounterparts. For each entry...

Tài liệu Báo cáo khoa học: "An Open Source Toolkit for Phrase-based and Syntax-based Machine Translation" docx

... node in the parse tree, and calculate the model score for each edge rooting at the node. The final output is the 1-best/k-best translations maintained by the root node of the parse tree. Since ... discriminative reordering model, a simple and fast language model, and an implementation of minimum error rate training that allows for various evaluation metrics for tuning the system. In addition, ... (SCFG/STSG) for the hierarchical phrase-based and syntax-based systems. Then, an n-gram language model is built on the target-language corpus. Finally, the resulting models are incorporated into the...

Tài liệu Báo cáo khoa học: "Exploring Syntactic Structural Features for Sub-Tree Alignment using Bilingual Tree Kernels" docx

... and the best dBTK for each cor-pus along with the polynomial kernel for plain features. In the HIT corpus, we use dBTK in the Root space and iBTK in the RgSST space; while for FBIS corpus, ... spaces in certain order for both corpora and examine the feature contribution to the align-ment results. In detail, the iBTKs and dBTKs are firstly combined with the polynomial kernel for plain ... and therefore, a relatively low performance. When enlarging the amount of training corpus to the HIT corpus, the ability of dBTKs excels and the benefit from data increas-ing of dBTKs is more...

Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt

... shown in Fig. 1B, the distance between the two termini of the inserted Ca2+-binding sites in the model structure of the EF-hand of STIM1 is within15 A˚. Accordingly, a total of six glycine linkers ... the contribution of the baselineslope using logarithmic fitting. The Tb3+-binding affinity of the protein was obtained by fitting normalized fluorescenceintensity data using the equation:f ¼ð½PTþ½MTþ ... itsluminal canonical EF-hand motif and subsequently oligomerizing to inter-act with the CRAC channel pore-forming subunit Orai1. In this work, weapplied a grafting approach to obtain the intrinsic...

Báo cáo khoa học: Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene ppt

... entropic gain due tointerrupted stacking, fluctuating nature of the hydro-gen bond and water organization in the vicinity of the mismatch might be the contributing factors for the increase in free ... deciphering the origin of the destabilization and hence, diminution of the melting temperature (Tm) in the former.Base stacking in the vicinity of A C mismatch in PNAÆDNA and DNA duplexesIntra ... throughout the dynamics in DDwtleading to an uninterrupted stacking at the steps flank-ing the mismatch. The difference in the A C mismatchhydrogen bond may therefore be attributed to the signi-ficant...

Báo cáo khoa học: Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae pot

... transported to the Golgi for further glycosylation(p2 form with molecular mass of 69 kDa). The p2 formof CPY traverses the Golgi and is packaged into vesi-cles destined for the vacuolar protein ... Asshown in Fig. 7, at 0 min of chase, p1 CPY was the predominant form. The p2 form was seen at the 5 mintime point. At a later time (10 min), mature CPY wasobserved together with some remaining ... temperature for 2 h. The PtdInsPstrips were then incubated with GST fusion proteins at aconcentration of 30–60 nm for fusion proteins or 60–120 nm for GST only for 2 h at room temperature. After washingwith...

Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf

... inhibitors, with Kivaluesof 2.2 lm (3) and 1.5 lm (4) for the lupin enzyme andof 2.1 lm (3) and 2.5 lm (4) for the human counter-part. These Kivalues lie in the range of the Kmvalues for ... asymmetrically acting Ap4A hydro-lases can reach the scissile bond either by extending the frame’, as in the case of compound 3,orbyshortening the count, when attacking the Pb-O-Pb¢bond ... oxymethylene group replacing one or twobridging oxygen(s) in the polyphosphate chain. These have been tested aspotential substrates and /or inhibitors of the symmetrically acting Ap4Ahydrolase...

Báo cáo khoa học: Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase pdf

... short a-heli-cal LID domain, situated in the C-terminal moiety,and the NMP-binding (NMPbind) domain move in aninduced-ﬁt mechanism, closing upon binding of the phosphate donor and acceptor ... to either hydrogen bond accep-tor or donor depending on its orientation, and pro-vides a ﬂexible way to accommodate either CMP or UMP in the NMP-binding site [22]. The residuesforming the hydrophobic ... Electron-density map of the dCMP-binding region for the R188M CMP kinase variant. The Fo) Fcomit map calculated for the dCMP–R188M CMP kinase complex in the absence of the dCMP model is green. The contour...

Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the speciﬁcity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf

... mentioned ﬁndings give another argumentfavouring the importance of ArgB263 in substrate binding toPA. The pronounced difference in interaction energies of the two arginine residues shows certain capability ... NHCO).Kinetic measurements The PA-catalysed hydrolysis of the arylamide bond wasfollowed by the absorbance or ﬂuorescence change during the release of the product (see Table 1 for the correspondingspectral ... [26]. The other substrates were obtained in dry organicsolvents in the presence of organic base (pyridine,N-methylmorpholine). The solvents used for the synthesisof the respective phenylacetyl arylamides...

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