Báo cáo khoa học: "The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer" pdf

... day of chemotherapyXia et al. Radiation Oncology 2011, 6:50http://www.ro-journal.com/content/6/1/50Page 8 of 9RESEARCH Open AccessThe effect of bioequivalent radiation dose on survival of patients ... biological radiation dose- response for patients of limited-stage small-cell lung cancer (LS-SCLC) treated with high radiation dose. Methods: Two hundred and five patients of LS-SCLC treated with sequential ... radiation dose on survival of patients with limited-stage small-cell lung cancer. Radiation Oncology 2011 6:50.Submit your next manuscript to BioMed Centraland take full advantage of: • Convenient...

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... Arg-HClin the absence of the chaperone precluded analysis of the effect of this concentration on the protectiveability of aB-crystallin.Reduction-induced aggregation of the insulin B-chainLight ... incubated alone (Fig. 2A,C). Addition of Arg-HCl(up to 250 mm) had a negligible effect on the amount of precipitation. Similarly, low and intermediate con-centrations of Gdn-HCl had no effect on the ... Inaddition, for each assay we used concentrations of aB-crystallin that only partially inhibited aggregation of the target protein in order to enable the effects of the compounds on the chaperone...

Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx

... site of RTA with G4stacked upon the G2-A5pair and able to make interactions with Asn122. (B) Model 2 is a variation of model 1 with the tetraloop bound in aconformation where G4stacks with ... an ionic interaction with the phosphodiester backbone of the substrate, thestructure of RTA also shows that this residue is at thecentre of a hydrogen bonding network, forming H-bonds with ... theD50(concentration giving half maximal depurination) by10-fold and over 100-fold, respectively (Fig. 2A). Substitu-tion of Arg258 with Ala (R258A) had no effect on activitywhereas substitution of...

Tài liệu Báo cáo khoa học: "The Effect of Pitch Accenting on Pronoun Referent Resolution" ppt

... attentional salience. One determiner of whether attentional or propositional effects are dominant is the type of information provided by the accented constituent. Because nonpronominals contribute ... attentional function. Therefore pitch accented pronominals are mainly interpreted with respect to Cf, for their attentional content. (3) The specific attentional consequences of each 291 The Effect ... may be nonlexical representations of concepts, or some hybrid of lexical, conceptual and sensory data. is preferred over a sequence of retentions, which is preferred over a sequence of shifts....

Báo cáo khoa học: The effect of replacing the axial methionine ligand with a lysine residue in cytochrome c-550 from Paracoccus versutus assessed by X-ray crystallography and unfolding ppt

... interactions (Fig. 4D). Effect of the M100K mutation on the stability of the native stateThe effect on protein stability upon introduction of aLys ligand to the heme-iron has been assessed for theM100K ... amounts of guanidinium hydrochloride (GdmHCl) the proteinunfolds resulting in the perturbation of a number of electronic absorption bands and the appearance in thespectrum of new ones. One of these, ... catalyseH2O2reduction with concomitant oxidation of a redu-cing substrate albeit with an extremely low rate [18].Unfolding by addition of chemical denaturants [12,13]Table 2. Hydrogen bonding interactions...

Báo cáo khoa học: The effect of heme on the conformational stability of micro-myoglobin doc

... native-like conformations.ConclusionsThe comparison of apo- and holo-lMb by MD simu-lations reveals a dramatic effect of the heme cofactor,which is seen to stabilize native Mb-like folded confor-mations ... conceiv-ably also contribute to the conformational stability of holo-lMb. Consistently, they are maintained over the1.5 ns of the simulation (Fig. 2).A comparison of the hydrogen-bond distances ... Journal compilation ª 2007 FEBS 93The effect of heme on the conformational stability of micro-myoglobinHong-Fang Ji1,2, Liang Shen1,2, Rita Grandori3and Norbert Mu¨ller21 Shandong Provincial...

Báo cáo khoa học: "The Effect of Translation Quality in MT-Based Cross-Language Information Retrieval" pptx

... so degradation of rule base mainly results in word translation errors instead of syntactic errors. Thus, degradation of dictionary and rule base has similar effect on retrieval effectiveness. ... on dictionary-based degradation comparable to the results on rule-based degrada-tion, we degrade the dictionary so that the varia-tion interval on translation quality is similar to that of ... the aspect of lexical coverage. Why lack research on analyzing effect of translation quality of MT system on CLIR performance? The possible reason might be the problem on how to control the...

Báo cáo khoa học: "The effect of domain and text type on text prediction quality" pptx

... prediction al-gorithm on four different text types (Wikipedia,Twitter, transcriptions of conversational speechand FAQ) with equal corpus sizes, we found thatthere is a clear effect of text type on ... Wikipediacorpus.6 ConclusionsIn Section 1, we asked two questions: (1) “Whatis the effect of text type differences on the quality of a text prediction algorithm?” and (2) “What isthe best choice of training ... our textprediction algorithm on four different types of Dutch text: Wikipedia, Twitter data, transcriptions of conversational speech, and web pages of Fre-quently Asked Questions (FAQ). The Wikipediacorpus...

Báo cáo khoa học: The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the Vibrio cholerae ToxR protein pot

... [30] of the protein, along with the distribu-tion of the charged groups on various loops ⁄ nonregu-lar regions of the molecule, seem to be ideal fortriggering conformational changes upon adsorption ... recogni-tion, the ionic strength of the medium would beexpected to have an effect on the binding [43]. Tostudy the effect of ionic strength on the conformation of ToxRp in the presence of ZnO NP, CD ... °C with increasing concentration of GdnHCl.Fig. 3. Shift in wavelength (kmax) of free and NP-adsorbed ToxRpat pH 8.0 and 25 °C with increasing concentration of urea. Effect of ZnO NPs on...

Báo cáo khoa học: The effect of pH on the initial rate kinetics of the dimeric biliverdin-IXa reductase from the cyanobacterium Synechocystis PCC6803 pptx

... the effect of pH on the kinetic parameters of a two-substrateenzyme, one substrate is held at 10 · Km(91% saturat-ing) and the variation of initial rate with the concen-tration of the second ... were conducted within thisrange of enzyme concentration. In a preliminary set of experiments, there was no substrate inhibition up to abiliverdin concentration of 50 lm, in clear distinctionto ... ﬁrst few sec-onds of the reaction under conditions when at least90% of the activity was retained; however, these areclearly not ideal conditions. With NADH as cofactor,the pK on the ‘less...

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