... sufficient response to allowfor an uncomplicated, successful resection of the GIST.While most patients respond to imatinib, many eventu-ally develop resistance. Initial (primary) resistance is defined ... neoadjuvant imat-inib therapy in patients with marginally resectable GISTs.A response to imatinib can allow for a less extensivethough still therapeutic oncologic resection.Competing interestsThe ... DeMatteo RP, Maki RG, Singer S, Gonen M, Brennan MF, AntonescuCR: Results of tyrosine kinase inhibitor therapy followed bysurgical resection for metastatic gastrointestinal stromaltumor. Ann...