Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
... the
destruction of cartilage. In this study, we investigate the role of
synovial macrophages and their main proinflammatory cytokines,
interleukin (IL)-1 and tumour necrosis factor-alpha (TNF-α), in
driving ... player in promoting the production of inflammatory
and degradative mediators in the OA synovium. In particular,
our results indicate a role for both...
... second binding loops of cystatin B and
family 2 cystatins and also what residues of this loop in
cystatin A may participate in the interaction.
To elucidate the role of the second binding loop of ... participates in the inhibition of papain
and most likely also of cathepsin L. The side chains of
Leu73 and Pro74 jointly contribute 45% of the total
unitary free...
... and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme for PAA and derivatives thereof, while maintaining
the hydrophobicity of the binding site.
To ... (k
cat
/K
m
)forp-hydroxyphenylgly-
cine methyl ester and phenylglycine methyl ester that were
similar to the wild-type values, whereas the specificity con-
stants for p-hydroxyphenyl...
... indicating
that, in the absence of coenzyme M, zinc is probably
coordinated by a single sulfur ligand and three oxygen or
nitrogen ligands. In the presence of coenzyme M, one
(N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In the
His237 fi Ala and Cys239 fi Ala mutants, coenzyme M
also seemed to bind efficiently by ligation to zinc indicating
that so...
... carboxyl group of the a-aminoadipoyl- side-chain
of penicillin N (1), with arginines 74 and 75 apparently
playing a less important role in side-chain binding. Taken
together, the results of this and ... residues in
binding the carboxylate linked to the nucleus of penicillin N
(Arg160 and Arg162) and the carboxylate of the a-amino-
adipoyl side-chain (Arg266). The resul...
... delivery. The frequency of developing
atopic dermatitis in the offspring was significantly
reduced by 2, 4, and 7 years [26-28], by 50%, 44%, and
36% respectively.
Similar studies have yielded ... stemmed from the fact that they have been
shown to reduce inflammatory cytokines and improve
intestinal permeability in vitro. Such effects would be
desirable in treating allergic...
... activity of a glucocorticoid-regulated inflammatory
cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.
7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-
matory therapy. ... their role in bone metabolism and repair
remains unclear.
Review of the evidence
To determine the role of COX-2 in bone repair, investiga-
tors have studied fracture healing i...
... evidence for hypoxia in
inflammatory and destructive joint disease, and discusses the
interplay between alterations in oxygen tension, vascularity
and inflammatory signalling pathways. In the present ... intracellular
domain of the Notch receptor (involved in the maintenance of
cells in an undifferentiated state), both of which notably
contain ankyrin repeat motifs...
... as
described earlier [9,10], the increased expression of
RANKL and RANK within synovial inflammatory tissue
[30–32], and the fact that many proinflammatory mediators
present in the synovial membrane, such ... consequently lead to increasing inter-
est in the role of osteoclasts in local bone erosion that is
driven by the hypothesis that synovial pannus makes use
Review...
... organization of bone
and other mineralized tissues and the mechanism of calcifi-
cation. In: Handbook of physiology, endocrinology, parathyroid
gland. Edited by Aubarch GD. Washington: American Physiologi-
cal ... 3-
hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc-
tase enzyme. These include naturally occurring lovastatin,
chemically modified simvastatin and pravastatin [1–...