Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps

Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps

Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps

... the destruction of cartilage. In this study, we investigate the role of synovial macrophages and their main proinflammatory cytokines, interleukin (IL)-1 and tumour necrosis factor-alpha (TNF-α), in driving ... player in promoting the production of inflammatory and degradative mediators in the OA synovium. In particular, our results indicate a role for both...
Ngày tải lên : 09/08/2014, 08:23
  • 12
  • 325
  • 0
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction. To elucidate the role of the second binding loop of ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total unitary free...
Ngày tải lên : 17/03/2014, 10:20
  • 10
  • 533
  • 0
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To ... (k cat /K m )forp-hydroxyphenylgly- cine methyl ester and phenylglycine methyl ester that were similar to the wild-type values, whereas the specificity con- stants for p-hydroxyphenyl...
Ngày tải lên : 17/03/2014, 23:20
  • 8
  • 561
  • 0
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

... indicating that, in the absence of coenzyme M, zinc is probably coordinated by a single sulfur ligand and three oxygen or nitrogen ligands. In the presence of coenzyme M, one (N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In the His237 fi Ala and Cys239 fi Ala mutants, coenzyme M also seemed to bind efficiently by ligation to zinc indicating that so...
Ngày tải lên : 17/03/2014, 23:20
  • 7
  • 464
  • 0
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain (Arg266). The resul...
Ngày tải lên : 18/03/2014, 01:20
  • 5
  • 462
  • 0
Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

... delivery. The frequency of developing atopic dermatitis in the offspring was significantly reduced by 2, 4, and 7 years [26-28], by 50%, 44%, and 36% respectively. Similar studies have yielded ... stemmed from the fact that they have been shown to reduce inflammatory cytokines and improve intestinal permeability in vitro. Such effects would be desirable in treating allergic...
Ngày tải lên : 08/08/2014, 21:20
  • 7
  • 560
  • 0
Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repair, investiga- tors have studied fracture healing i...
Ngày tải lên : 09/08/2014, 01:21
  • 3
  • 475
  • 0
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... intracellular domain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notably contain ankyrin repeat motifs...
Ngày tải lên : 09/08/2014, 01:22
  • 9
  • 499
  • 0
Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

... as described earlier [9,10], the increased expression of RANKL and RANK within synovial inflammatory tissue [30–32], and the fact that many proinflammatory mediators present in the synovial membrane, such ... consequently lead to increasing inter- est in the role of osteoclasts in local bone erosion that is driven by the hypothesis that synovial pannus makes use Review...
Ngày tải lên : 09/08/2014, 01:23
  • 7
  • 343
  • 0
Báo cáo y học: "The role of statins as potential targets for bone formation" pptx

Báo cáo y học: "The role of statins as potential targets for bone formation" pptx

... organization of bone and other mineralized tissues and the mechanism of calcifi- cation. In: Handbook of physiology, endocrinology, parathyroid gland. Edited by Aubarch GD. Washington: American Physiologi- cal ... 3- hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc- tase enzyme. These include naturally occurring lovastatin, chemically modified simvastatin and pravastatin [1–...
Ngày tải lên : 09/08/2014, 03:24
  • 4
  • 392
  • 0

Xem thêm

Từ khóa: